Investigations into tumor accumulation and peroxisome proliferator activated receptor binding by F-18 and C-11 fatty acids

Jonson, Stephanie D.; Welch, Michael J.

doi:10.1016/s0969-8051(01)00300-6

Cited by 8 publications

(4 citation statements)

References 10 publications

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“…11 C-acetate is a marker of oxidative metabolism also used in myocardial perfusion studies that has shown potential use in tumor imaging. 56 However, in this experiment, its uptake was not significantly different between brain and tumor, with an uptake ratio of only 1.12. Therefore, this isotope was not considered suitable for metabolic evaluation of the F98-Fischer model.…”

Section: Discussioncontrasting

confidence: 56%

Standardization and Detailed Characterization of the Syngeneic Fischer/F98 Glioma Model

Mathieu

Lecomte

Tsanaclis

et al. 2007

Can. j. neurol. sci.

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296Malignant gliomas are aggressive brain tumors with a particularly poor prognosis. The standard treatment, consisting of maximal resective surgery followed by radiation and chemotherapy at recurrence, offers at best palliative control. Survival generally ranges from a few months to about 15 months for glioblastoma multiforme, the most aggressive of these lesions. 1 Many therapeutic strategies are currently under ABSTRACT: Introduction: Adequate animal glioma models are mandatory for the pursuit of preclinical research in neuro-oncology. Many implantation models have been described, but none perfectly emulate human malignant gliomas. This work reports our experience in standardizing, optimizing and characterizing the Fischer/F98 glioma model on the clinical, pathological, radiological and metabolic aspects. Materials and methods: F98 cells were implanted in 70 Fischer rats, varying the quantity of cells and volume of implantation solution, and using a micro-infusion pump to minimize implantation trauma, after adequate coordinates were established. Pathological analysis consisted in hematoxylin and eosin (H&E) staining and immunohistochemistry for GFAP, vimentin, albumin, TGF-b1, TGFb2, CD3 and CD45. Twelve animals were used for MR imaging at 5, 10, 15 and 20 days. Corresponding MR images were compared with pathological slides. Two animals underwent 18 F-FDG and 11 C-acetate PET studies for metabolic characterization of the tumors. Results: Implantation with 1x10 4 cells produced a median survival of 26 days and a tumor take of 100%. Large infiltrative neoplasms with a necrotic core were seen on H&E. Numerous mitosis, peritumoral infiltrative behavior, and neovascular proliferation were also obvious. GFAP and vimentin staining was positive inside the tumor cells. Albumin staining was observed in the extracellular space around the tumors. CD3 staining was negligible. The MR images correlated the pathologic findings.18 F-FDG uptake was strong in the tumors. Conclusion: The standardized model described in this study behaves in a predictable and reproducible fashion, and could be considered for future pre-clinical studies. It adequately mimics the behavior of human malignant astrocytomas. Can. J. Neurol. Sci.

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Section: Discussioncontrasting

confidence: 56%

Standardization and Detailed Characterization of the Syngeneic Fischer/F98 Glioma Model

Mathieu

Lecomte

Tsanaclis

et al. 2007

Can. j. neurol. sci.

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“…Aromatic fatty acids display antitumor effects with phenyl acetate. 11C-Acetate showed better tumor accumulation than 11C-phenylacetic acid or 18F-fluorophenyl-acetic acid in animal studies [86].…”

Section: Acetatementioning

confidence: 84%

“…This imaging agent of oxidative metabolism has potential use in tumor imaging [86]. Aromatic fatty acids display antitumor effects with phenyl acetate.…”

Section: Acetatementioning

confidence: 99%

The pre-requisite of a second-generation glioma PET biomarker

Borbély

Wintermark

Martos³

et al. 2010

Journal of the Neurological Sciences

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“…Although it is accepted that the metabolic fate of acetate in tumors differs from that in normal tissue, the exact pathway has not been fully elucidated. They employed as effective cancer treatment agents appear to be acting through a metabolic pathway (Jonson and Welch, 2002). In general, 11 C necessitates an onsite cyclotron and requires use of radiotracer soon after preparation.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of 2-R1-2-(4-(2-fluoroethoxy)benzamido)acetate as potential PET imaging agents

Liu

et al. 2011

Med Chem Res

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Investigations into tumor accumulation and peroxisome proliferator activated receptor binding by F-18 and C-11 fatty acids

Cited by 8 publications

References 10 publications

Standardization and Detailed Characterization of the Syngeneic Fischer/F98 Glioma Model

Standardization and Detailed Characterization of the Syngeneic Fischer/F98 Glioma Model

The pre-requisite of a second-generation glioma PET biomarker

Synthesis of 2-R1-2-(4-(2-fluoroethoxy)benzamido)acetate as potential PET imaging agents

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