Investigations into the mechanism of lead toxicity to the freshwater pulmonate snail, Lymnaea stagnalis

Brix, Kevin V.; Esbaugh, Andrew J.; Munley, Kathleen M.; Grosell, Martin

doi:10.1016/j.aquatox.2011.11.007

Cited by 33 publications

(48 citation statements)

References 34 publications

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“…These results suggest that at relatively low Pb concentrations, where Pb toxicity to C. dubia occurs, entry of Pb 2+ may occur via a channel or transporter with low affinity for Ca 2+ (e.g., divalent metal transporter 1) and, therefore, little protection is afforded by competition with Ca 2+ under these conditions . These findings are consistent with a recent study that concluded that inhibition of Ca 2+ uptake is not the primary mechanism of Pb toxicity to the freshwater snail L. stagnalis , 1 of the most sensitive species for Pb toxicity .…”

Section: Resultssupporting

confidence: 90%

The derivation of effects threshold concentrations of lead for European freshwater ecosystems

Sprang

Nys

Blust

et al. 2016

Enviro Toxic and Chemistry

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The main objective of the present study was to derive ecologically relevant effect threshold concentrations of (dissolved) Pb for selected European Union (EU) freshwater rivers, using the 2008 EU Voluntary Risk Assessment Report as a starting point and more advanced methodologies than those used in the Voluntary Risk Assessment Report. This included 1) implementing more robust quality criteria for selecting chronic toxicity data; 2) the conversion of total to dissolved Pb concentrations using a combination of an empirical equation relating inorganic Pb solubility and geochemical speciation modeling to account for effects of dissolved organic matter; 3) the use of bioavailability models for chronic toxicity for species belonging to 3 different trophic levels; and 4) the use of robust methods for large data set handling (such as species sensitivity distribution [SSD] analysis). The authors used published bioavailability models for an algal species (Pseudokirchneriella subcapitata) and a daphnid (Ceriodaphnia dubia) and developed a new model for the fathead minnow (Pimephales promelas). The research has shown that these models are also useful for, and reasonably accurate in, predicting chronic toxicity to other species, including a snail, a rotifer, midge larvae, and an aquatic plant (read-across). A comprehensive chronic toxicity data set for Pb was compiled, comprising 159 individual high-quality toxicity data for 25 different species. By applying the total dissolved conversion and the bioavailability models, normalized toxicity values were obtained, which were then entered into a SSD analysis. Based on the parametric best-fitting SSDs, the authors calculated that ecological threshold concentrations of Pb protecting 95% of freshwater species for 7 selected European freshwater scenarios were between 6.3 μg dissolved Pb/L and 31.1 μg dissolved Pb/L.

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Section: Resultssupporting

confidence: 90%

The derivation of effects threshold concentrations of lead for European freshwater ecosystems

Sprang

Nys

Blust

et al. 2016

Enviro Toxic and Chemistry

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“…Comparison of ( A ) biotic ligand model (BLM)—and multiple linear regression (MLR)–predicted and ( B ) hardness‐predicted 20% effect concentrations (EC20) for Lymnaea stagnalis . Grosell et al (♦); Parametrix (▪); Brix et al (▴); Esbaugh et al (●). Filled symbols are BLM predictions; open symbols are MLR predictions; “plus” symbols are hardness predictions.…”

Section: Discussionmentioning

confidence: 99%

Development of biotic ligand model–based freshwater aquatic life criteria for lead following US Environmental Protection Agency guidelines

DeForest

Santore

Ryan

et al. 2017

Enviro Toxic and Chemistry

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The US Environmental Protection Agency's (USEPA's) current ambient water quality criteria (AWQC) for lead (Pb) in freshwater were developed in 1984. The criteria are adjusted for hardness, but more recent studies have demonstrated that other parameters, especially dissolved organic carbon (DOC) and pH, have a much stronger influence on Pb bioavailability. These recent studies have been used to support development of a biotic ligand model (BLM) for Pb in freshwater, such that acute and chronic Pb toxicity can be predicted over a wide range of water chemistry conditions. Following USEPA guidelines for AWQC development and using a methodology consistent with that used by the USEPA in developing its recommended BLM-based criteria for copper in 2007, we propose acute and chronic BLM-based AWQC for Pb in freshwater. In addition to the application of the BLM approach that can better account for site-specific Pb bioavailability, the toxicity data sets presented are much more robust than in 1984, and there are now sufficient chronic Pb toxicity data available that use of an acute-to-chronic ratio is no longer necessary. Over a range of North American surface waters with representative water chemistry conditions, proposed acute BLM-based Pb criteria ranged from approximately 20 to 1000 μg/L and chronic BLM-based Pb criteria ranged from approximately 0.3 to 40 μg/L. The lowest criteria were for water with low DOC (1.2 mg/L), pH (6.7), and hardness (4.3 mg/L as CaCO3), whereas the highest criteria were for water with high DOC (9.8 mg/L), pH (8.2), and hardness (288 mg/L as CaCO ). Environ Toxicol Chem 2017;36:2965-2973. © 2017 SETAC.

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“…For instance, a stand‐alone paper from the 1970s that reported a snail's anomalous sensitivity to Pb was skeptically regarded. More than 30 y later, open‐minded skepticism led to follow‐on studies from a new generation of scientists that not only affirmed the anomalous early report of sensitivity but also led to important advances in comparative physiology and underlying mechanisms of toxicity (Brix et al ). Similarly, early reports that freshwater mussels and other mollusks were unusually sensitive to ammonia were not widely persuasive.…”

Section: Promoting Scientific Integrity In Ecotoxicologymentioning

confidence: 99%

“…In the United States, about 40% of national research and development is funded by the private sector (NAS 2017). In the United States, public funding for university research on the effects of chemicals in the environment has consistently declined since 2000 (Bernhardt et al 2017;Burton et al 2017), which implies that without industry-academia collaborations, there would be much less substantive university research. The need for sufficient funding to support training and research can trump concerns over the color of money, as captured in a university president's quip, "the only problem with tainted research funding is there t'aint enough of it" (Krimsky 2003).…”

Section: Academic-industry Collaborationsmentioning

confidence: 99%

Scientific integrity issues in Environmental Toxicology and Chemistry: Improving research reproducibility, credibility, and transparency

Mebane

Sumpter

Fairbrother

et al. 2019

Integr Envir Assess & Manag

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High‐profile reports of detrimental scientific practices leading to retractions in the scientific literature contribute to lack of trust in scientific experts. Although the bulk of these have been in the literature of other disciplines, environmental toxicology and chemistry are not free from problems. While we believe that egregious misconduct such as fraud, fabrication of data, or plagiarism is rare, scientific integrity is much broader than the absence of misconduct. We are more concerned with more commonly encountered and nuanced issues such as poor reliability and bias. We review a range of topics including conflicts of interests, competing interests, some particularly challenging situations, reproducibility, bias, and other attributes of ecotoxicological studies that enhance or detract from scientific credibility. Our vision of scientific integrity encourages a self‐correcting culture that promotes scientific rigor, relevant reproducible research, transparency in competing interests, methods and results, and education. Integr Environ Assess Manag 2019;00:000–000. © 2019 SETAC

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Investigations into the mechanism of lead toxicity to the freshwater pulmonate snail, Lymnaea stagnalis

Cited by 33 publications

References 34 publications

The derivation of effects threshold concentrations of lead for European freshwater ecosystems

The derivation of effects threshold concentrations of lead for European freshwater ecosystems

Development of biotic ligand model–based freshwater aquatic life criteria for lead following US Environmental Protection Agency guidelines

Scientific integrity issues in Environmental Toxicology and Chemistry: Improving research reproducibility, credibility, and transparency

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