Investigations into the formation and characterization of phospholipid microemulsions. III. Pseudo-ternary phase diagrams of systems containing water-lecithin-isopropyl myristate and either an alkanoic acid, amine, alkanediol, polyethylene glycol alkyl ether or alcohol as cosurfactant

Aboofazeli, Reza; Lawrence, Catherine B.; Wicks, Stephen R.; Lawrence, M. Jayne

doi:10.1016/0378-5173(94)90402-2

Cited by 77 publications

(32 citation statements)

References 22 publications

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“…[29][30][31] The presence of cosurfactants provides the interfacial film sufficient flexibility to assume the different curvatures required to form MEs over a wide range of compositions. [32][33][34] In our preliminary test, the best solubilization and microemulsifying effect and resistance to infinite dilution were found for the MCT/BJO/S75/HS 15/PEG 400 combination, the ratio of which was confirmed by aqueous phase titration.…”

Section: Me Formulationmentioning

confidence: 93%

Intravenous microemulsion of docetaxel containing an anti-tumor synergistic ingredient (Brucea javanica oil): formulation and pharmacokinetics

Shi-lin¹,

Chen²,

Ye³

et al. 2013

IJN

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Section: Me Formulationmentioning

confidence: 93%

Intravenous microemulsion of docetaxel containing an anti-tumor synergistic ingredient (Brucea javanica oil): formulation and pharmacokinetics

Shi-lin¹,

Chen²,

Ye³

et al. 2013

IJN

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“…In the pseudo-ternary phase diagram, the presence and extent of the microemulsion region depends on the partition coefficient of co-surfactant and the surfactant/ co-surfactant ratio. 38,[40][41][42]46) The butanol used in this study has medium level water solubility; its affinity to the IPM used in Before treatment: baseline (initial assessment). After treatment: at the end of the study (at 6th week, final assessment).…”

Section: Discussionmentioning

confidence: 99%

“…The lecithin/IPM/butanol/water combination is widely used when developing a water-in-oil or oil-in-water type microemulsion. [38][39][40][41][42] The lecithin used in this study consists of 93% phosphatidylcholine, which is slightly too lipophilic to form a balanced microemulsion when used as the sole surfactant. 43) Lecithin tends to form lamellar structures/bilayers, since it has a high critical packing parameter (CPP, approximately 0.8).…”

Section: Discussionmentioning

confidence: 99%

Preparation and Evaluation of Topical Microemulsion System Containing Metronidazole for Remission in Rosacea

et al. 2012

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The aim of this study was to prepare a topical water-in-oil type microemulsion containing metronidazole and to compare its effectiveness with a commercial gel product in the treatment of rosacea. A pseudoternary phase diagram (K m 2 : 1) was constructed using lecithin/butanol/isopropyl myristate/water. The microemulsion was chosen from the microemulsion region in the phase diagram. The formulation was a water-in-oil type microemulsion (droplet size: 11.6 nm, viscosity: 457.3 mPa·s, conductivity: 1.5 µs/cm, turbidity: 6.89 NTU) and the addition of the metronidazole did not alter the properties of the system. The release experiment showed that the release rate of metronidazole from the commercial gel product was higher than that of the microemulsion. Stability experiments showed that the metronidazole microemulsion remained stable for at least 6 months; none of the characteristic properties of the microemulsion had changed, the system retained its clarity and there was no sign that crystallization of metronidazole has occurred. Microemulsion was compared to a gel product in a randomized, double-blind, baseline-controlled, split-face clinical trial for the treatment of patients. After the 6-week treatment period there was a statistically significant difference in reduction of the main symptoms of rosacea. Of the patients treated with the microemulsion, 17% experienced complete relief from inflammatory lesions, and 50% from erythema. The microemulsion resulted in complete relief in 38% of the patients with telangiectasia while the commercial product did not provide any relief of telangiectasia symptoms. In conclusion, the microemulsion containing metronidazole was found to be more effective in reducing the symptoms of rosacea compared to the commercial gel product. Key words microemulsion; metronidazole; rosaceaRosacea is a chronic skin disorder of unknown etiology that is more common in women than men.

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“…Glycerol and polyethylene glycol resulted in very cloudy emulsions. This could be due to the poor penetration of glycerol and polyethylene glycol in the surfactant layers at the interface (31,32). Propylene glycol (PG), ethanol, glycofurol and Tween 80, all were efficient in improving microemulsification of propofol by SHS 15.…”

Section: Screening Of Cosurfactantsmentioning

confidence: 99%

Design and Evaluation of Microemulsions for Improved Parenteral Delivery of Propofol

Date

Nagarsenker

2008

AAPS PharmSciTech

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Abstract. The objective of this investigation was to evaluate the potential of the microemulsions to improve the parenteral delivery of propofol. Pseudo-ternary phase diagrams were plotted to identify microemulsification region of propofol. The propofol microemulsions were evaluated for globule size, physical and chemical stability, osmolarity, in vitro hemolysis, pain caused by injection using rat paw-lick test and in vivo anesthetic activity. The microemulsions exhibited globule size less than 25 nm and demonstrated good physical and chemical stability. Propofol microemulsions were slightly hypertonic and resulted in less than 1% hemolysis after 2 h of storage with human blood at 37°C. Rat paw-lick test indicated that propofol microemulsions were significantly less painful as compared to the marketed propofol formulation. The anesthetic activity of the microemulsions was similar to the marketed propofol formulation indicating that they do not compromise the pharmacological action of propofol. The stability studies indicated that the microemulsions were stable for 3 months when stored at 5±3°C. Thus, microemulsions appeared to be an interesting alternative to the current propofol formulations.

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Investigations into the formation and characterization of phospholipid microemulsions. III. Pseudo-ternary phase diagrams of systems containing water-lecithin-isopropyl myristate and either an alkanoic acid, amine, alkanediol, polyethylene glycol alkyl ether or alcohol as cosurfactant

Cited by 77 publications

References 22 publications

Intravenous microemulsion of docetaxel containing an anti-tumor synergistic ingredient (Brucea javanica oil): formulation and pharmacokinetics

Intravenous microemulsion of docetaxel containing an anti-tumor synergistic ingredient (Brucea javanica oil): formulation and pharmacokinetics

Preparation and Evaluation of Topical Microemulsion System Containing Metronidazole for Remission in Rosacea

Design and Evaluation of Microemulsions for Improved Parenteral Delivery of Propofol

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