Investigations into the association between polymorphisms in the interleukin-10 gene and risk of early-onset preeclampsia

Abstract

ABSTRACT. In this case-control study, we assessed the influence of IL-10 -1082A/G and -819T/C on the development of preeclampsia. The IL-10 -1082A/G and -819T/C polymorphisms were assessed by polymerase chain reaction-restriction fragment length polymorphism. The genotype distributions of the IL-10 -1082A/G and -819T/C polymorphisms in the control subjects were in conformance with Hardy-Weinberg equilibrium (HWE; P = 0.46 and 0.17). Unconditional logistic regression analyses revealed that individuals carrying the CC genotype of IL-10 -819T/C were associated with an increased risk of preeclampsia compared to the TT genotype. The odds ratio (95% confidence interval) for the CC genotype of IL-10

Polymorphisms in interleukin-6 and interleukin-10 may be associated with risk of preeclampsia

“…Previous investigations have tested the association between IL-10 gene polymorphisms and preeclampsia development, but with conflicting results (Stonek et al, 2008;Vural et al, 2010;Valencia Villalvazo et al, 2012;Pissetti et al, 2014;Sowmya et al, 2014;Song and Zhong, 2015;Liu et al, 2015). Liu et al (2015) and Sowmya et al (2014) reported the IL-10 -819T/C genetic variant to be associated with increased preeclampsia risk in pregnant women in China and India.…”

“…Liu et al (2015) and Sowmya et al (2014) reported the IL-10 -819T/C genetic variant to be associated with increased preeclampsia risk in pregnant women in China and India. Similarly, in a study of 177 preeclamptic pregnant women and 182 controls, Song and Zhong (2015) found that the IL-10 -592A/C SNP elevated risk of early-onset preeclampsia in a Chinese population.…”

“…A deficiency in placental IL-10 has been reported in pregnant women with preeclampsia in comparison to control subjects, and serum IL-10 level is associated with genetic variations in the IL-10 promoter (Makris et al, 2006). Several previous studies have analyzed the association between IL-10 gene polymorphisms and development of preeclampsia, but their results conflict (Vural et al, 2010;Xie et al, 2011;Valencia Villalvazo et al, 2012;Liu et al, 2015). Moreover, none has investigated the relationship between IL-6 genetic variation and risk of this developing this condition in pregnant Chinese women.…”

A review of key cytokines based on gene polymorphism in the pathogenesis of pre‐eclampsia

“…In the Asian population, Liu et al. reported that the CC genotype of IL‐10‐819T/C enhanced the onset risk of PE in the Chinese population, while ‐1082A/G may not be related to the onset of PE 41 . Similar results were obtained in a case‐control study in India also demonstrating that ‐592A/C may be involved in the pathogenesis of PE 42 .…”

Association between interleukin-4 polymorphisms and risk of pre-eclampsia in a population of Chinese pregnant women

“…Three common polymorphisms of IL-4 were observed, including C-590T, C+33T and G-1098T. Although several recent studies have indicated that many polymorphisms of are involved in the pathogenesis of pre-eclampsia (Liu et al, 2015;Ren et al, 2016;Sun et al, 2016b;Tavakkol Afshari et al, 2016;Wang et al, 2016). However, only two studies have reported the association of IL-4 polymorphism with the development of pre-eclampsia so far (Fraser et al, 2008;Kang et al, 2014).…”