Investigations in the Chemotherapy of Malaria in West Africa

Drug Resistance in Protozoa

“…Several workers observed that the numbers of gametocytes present in patients treated with sulphadiazine or proguanil were greater than in patients treated with quinine or mepacrine (Mackerras & Ercole, 1948;Shute & Maryon, 1951 ;Findlay, Maegraith, Markson & Holden, 1946;Ramakrishnan, Young, Jeffery, Burgess & McLendon, 1952). It was also noticed that in the majority of chicks infected with the proguanil-resistant strain of Plasmodium gallinaceum the proportion of gametocytes to asexual parasites was greater than in the parent strain; this was particularly noticeable before the strain had become fully resistant to a particular dose of drug (Bishop & Birkett, 1948).…”