Investigations for the detection of genotoxic substances on TLC plates

Value and limitation ofin vitrobioassays to support the application of the threshold of toxicological concern to prioritise unidentified chemicals in food contact materials

“…Recently, this technique has been adapted to detect endocrine active chemicals (Klingelhofer and Morlock 2015), showing promising, high potential to detect very low levels. Attempts to combine the Ames test and SOS-umu test with TLC have been undertaken (Egetenmeyer and Weiss 2017;Weiss et al 2017). Further work is necessary to assess the value of such an approach and to validate it against a number of potent and less potent direct DNA-reactive mutagens in complex mixtures such as FCM migrates/extracts.…”