Investigational anti IL-13 asthma treatments: a 2023 update

Matera, Maria Gabriella; Ora, Josuel; Calzetta, Luigino; Rogliani, Paola; Cazzola, Mario

doi:10.1080/13543784.2023.2215425

Cited by 6 publications

(2 citation statements)

References 95 publications

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“…Earlier studies have established that IL-12 can exacerbate cytotoxic effects in mice with autoimmune thyroiditis by eliciting a Th1 immune response ( 36 ). IL-13, a member of the interleukin family, is largely secreted by activated Th2 cells and plays a critical role in allergic inflammation ( 37 ). It promotes M2 polarization.…”

Section: Discussionmentioning

confidence: 99%

Causal relationship between inflammatory cytokines and autoimmune thyroid disease: a bidirectional two-sample Mendelian randomization analysis

Yao,

Guo,

Tan

et al. 2024

Front. Immunol.

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BackgroundAutoimmune thyroid disease (AITD) ranks among the most prevalent thyroid diseases, with inflammatory cytokines playing a decisive role in its pathophysiological process. However, the causal relationship between the inflammatory cytokines and AITD remains elusive.MethodsA two-sample Mendelian randomization (MR) analysis was performed to elucidate the causal connection between AITD and 41 inflammatory cytokines. Genetic variations associated with inflammatory cytokines were sourced from the FinnGen biobank, whereas a comprehensive meta-analysis of genome-wide association studies (GWASs) yielded data on Graves’ disease (GD) and Hashimoto thyroiditis. Regarding the MR analysis, the inverse variance-weighted, MR-Egger, and weighted median methods were utilized. Additionally, sensitivity analysis was conducted using MR-Egger regression, MR-pleiotropy residual sum, and outliers.ResultsSeven causal associations were identified between inflammatory cytokines and AITD. High levels of tumor necrosis factor–β and low levels of stem cell growth factor–β were indicative of a higher risk of GD. In contrast, high levels of interleukin-12p70 (IL-12p70), IL-13, and interferon-γ and low levels of monocyte chemotactic protein–1 (MCP-1) and TNF-α suggested a higher risk of HD. Moreover, 14 causal associations were detected between AITD and inflammatory cytokines. GD increases the levels of macrophage inflammatory protein–1β, MCP-1, monokine induced by interferon-γ (MIG), interferon γ–induced protein 10 (IP-10), stromal cell–derived factor–1α, platelet-derived growth factor BB, β–nerve growth factor, IL-2ra, IL-4, and IL-17 in blood, whereas HD increases the levels of MIG, IL-2ra, IP-10, and IL-16 levels.ConclusionOur bidirectional MR analysis revealed a causal relationship between inflammatory cytokines and AITD. These findings offer valuable insights into the pathophysiological mechanisms underlying AITD.

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Section: Discussionmentioning

confidence: 99%

Causal relationship between inflammatory cytokines and autoimmune thyroid disease: a bidirectional two-sample Mendelian randomization analysis

Yao,

Guo,

Tan

et al. 2024

Front. Immunol.

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“…Th2-released cytokines interleukin-4 (IL-4), IL-10 and especially IL-13 may play a part in the induction of proteinuria ( 7 ). IL-13 is a pleiotropic type 2 cytokine involved in the pathogenesis of many allergic ( 8 ), inflammatory ( 9 ) and malignant conditions ( 10 ). In MCD patients, IL-13 may change glomerular permeability and cause proteinuria ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

Relation between interleukin-13 and annexin-V levels and carotid intima-media thickness in nephrotic syndrome

Elsehmawy,

Gouda,

Diab

et al. 2024

J Circ Biomark

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Background and aim: The aim of the current study is to assess the relation between carotid intima-media thickness (CIMT) measurements, renal Doppler resistive index (RI) and serum levels of interleukin-13 (IL-13) and annexin-V (An-V) in children with idiopathic nephrotic syndrome (INS). Materials and methods: The present case-control study was conducted on 60 children with INS and 60 age- and sex-matched healthy children. All participants were subjected to evaluation of serum levels of IL-13 and An-V and ultrasound Doppler measurement of CIMT and renal RI. Results: Patients expressed significantly higher An-V (5.9 ± 2.6 vs. 2.1 ± 0.8 ng/mL, p<0.001) and IL-13 (19.2 ± 7.6 vs. 3.4 ± 1.4 ng/L) levels when compared with healthy counterparts. Moreover, it was shown that patients had significantly higher CIMT (0.49 ± 0.06 vs. 0.35 ± 0.03, p<0.001) as compared to controls. No significant differences were noted between the studied groups regarding right or left RIs. Correlation analysis identified significant direct correlation between serum An-V levels and albumin/creatinine ratio (ACR) (r = 0.55), cholesterol (r = 0.48), triglycerides (r = 0.36), IL-13 (r = 0.92) and CIMT (r = 0.53). Similar correlations could be found between serum IL-13 levels and CIMT measurements and the corresponding parameters. Conclusions: The present study suggests an association between higher early atherosclerosis expressed as elevated CIMT measurements in children with INS and elevated serum levels of An-V and IL-13.

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Pathogenesis-based application of biologics for chronic rhinosinusitis: Current and future perspectives

Okano,

Kanai,

Oka

2024

Auris Nasus Larynx

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Investigational anti IL-13 asthma treatments: a 2023 update

Cited by 6 publications

References 95 publications

Causal relationship between inflammatory cytokines and autoimmune thyroid disease: a bidirectional two-sample Mendelian randomization analysis

Causal relationship between inflammatory cytokines and autoimmune thyroid disease: a bidirectional two-sample Mendelian randomization analysis

Relation between interleukin-13 and annexin-V levels and carotid intima-media thickness in nephrotic syndrome

Pathogenesis-based application of biologics for chronic rhinosinusitis: Current and future perspectives

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