Investigation on wound healing effect of Mediterranean medicinal plants and some related phenolic compounds: A review

Mssillou, Ibrahim; Bakour, Meryem; Slighoua, Meryem; Laaroussi, Hassan; Saghrouchni, Hamza; Amrati, Fatima Ez-Zahra; Lyoussi, Badiaâ; Derwich, Elhoussine

doi:10.1016/j.jep.2022.115663

Cited by 38 publications

(37 citation statements)

References 271 publications

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“…Likewise, in the phytochemistry world, a lot of plants (for example Mediterranean plants) were used for a while to cure wounds and skin injuries [ 28 ]. During the years it has been demonstrated that these wound repair properties are often ascribed to phenolic compounds [ 29 ]. Polyphenols are a large family of secondary metabolites of plants characterized by the presence of a huge number of hydroxyl groups attached to aromatic rings.…”

Section: Introductionmentioning

confidence: 99%

Natural Compounds and Biopolymers-Based Hydrogels Join Forces to Promote Wound Healing

et al. 2023

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Rapid and complete wound healing is a clinical emergency, mainly in pathological conditions such as Type 2 Diabetes mellitus. Many therapeutic tools are not resolutive, and the research for a more efficient remedial remains a challenge. Wound dressings play an essential role in diabetic wound healing. In particular, biocompatible hydrogels represent the most attractive wound dressings due to their ability to retain moisture as well as ability to act as a barrier against bacteria. In the last years, different functionalized hydrogels have been proposed as wound dressing materials, showing encouraging outcomes with great benefits in the healing of the diabetic wounds. Specifically, because of their excellent biocompatibility and biodegradability, natural bioactive compounds, as well as biomacromolecules such as polysaccharides and protein, are usually employed in the biomedical field. In this review, readers can find the main discoveries regarding the employment of naturally occurring compounds and biopolymers as wound healing promoters with antibacterial activity. The emerging approaches and engineered devices for effective wound care in diabetic patients are reported and deeply investigated.

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Section: Introductionmentioning

confidence: 99%

Natural Compounds and Biopolymers-Based Hydrogels Join Forces to Promote Wound Healing

et al. 2023

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“…25 Glycosides are known to accelerate the wound healing process and our study revealed the presence of such phytochemical groups in the extract. 26 The third-day observation showed that the mean densities of fibroblasts in all of the concentration groups were significantly different from those of the negative control group. Figure 1 shows that the fibroblast densities in all of the concentration groups remained low as the fibroblasts were yet to play a role in the inflammation phase.…”

Section: Resultsmentioning

confidence: 91%

Effects of Stelechocarpus burahol [Blume] Leaf Ethanol Extract Ointment on Burns Healing

2022

TJNPR

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healing process of open wounds, suggest that 70 % ethanol extract of Kepel leaves could boost the healing process of burn wounds. This study therefore aimed to evaluate the potential of Stelechocarpus burahol leaves in burn wound healing. The study was conducted using rats that were induced with third-degree burns. The rats were observed by measuring four parameters, namely the number of macrophages, the density of fibroblasts, the speed of re-epithelialisation and the decrease in the surface area of the burn wound. Measurement was carried out using the Image Raster 3.0 application. This parameter measurement supported the data for evaluating the potential of Stelechocarpus burahol leaves as a burn wound medication.

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“… Compounds Biological activities Refs. 4-Chloro-3,5-dimethylphenol (chloroxylenol) Antimicrobial, skin and wound disinfection 37 Cetene Antimicrobial and antioxidant 57 Pentacosane Antioxidant and antimicrobial 58 1-Eicosanol Antibacterial and antioxidant 28 , 59 Hexadecanoic acid, methyl ester Antibacterial, antifungal, and anti-inflammatory 60 – 62 9,12-Octadecadienoic acid (Z,Z)-, methyl ester Anti-inflammatory, antibacterial, skin repair and wound healing 40 , 63 , 64 9-Octadecenoic acid, methyl ester, (E)- Anti-inflammatory, antibacterial, skin repair and wound healing 40 , 63 , 64 cis-Vaccenic acid Wound healing, antibacterial, hypolipidemic and antioxidant 39 , 65 Erucic acid Antibacterial and wound healing 38 , 41 Diisooctyl phthalate Wound healing and antimicrobial 34 – 36 Daidzein Antimicrobial, antioxidant, anti-inflammatory, and wound healing 43 – 46...…”

Section: Resultsmentioning

confidence: 99%

“…(AUMC 15510) produced high amounts of daidzein at 81,286.11 µg/g followed by naringenin with concentration of 27,378.15 µg/g, while caffeic acid and quercetin were detected at concentration of (7948.79 and 3652.43 µg/g), respectively. Based on the previous literatures, phenolic and flavonoid compounds have potential biological activity with different mechanisms for example daidzein has potent antioxidant, anti-inflammatory, and wound healing properties [43][44][45][46] . Also, naringenin represents a potent antioxidant molecule through it is capability of UV absorption so it has antigenotoxic and photoprotector properties 47,48 .…”

Section: Gas Chromatography-mass Spectrometry (Gc-ms) and High-perfor...mentioning

confidence: 99%

The antimicrobial, antibiofilm, and wound healing properties of ethyl acetate crude extract of an endophytic fungus Paecilomyces sp. (AUMC 15510) in earthworm model

Salem

El-Maraghy

Abdel-Mallek

et al. 2022

Sci Rep

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The endophytic fungus Paecilomyces sp. (AUMC 15510) was isolated from healthy stem samples of the Egyptian medicinal plant Cornulaca monacantha. We used GC–MS and HPLC analysis to identify the bioactive constituents of ethyl acetate crude extract of Paecilomyces sp. (PsEAE). Six human microbial pathogens have been selected to evaluate the antimicrobial activity of PsEAE. Our data showed that the extract has significant antimicrobial activity against all tested pathogens. However, the best inhibitory effect was observed against Bacillus subtilis ATCC 6633 and Pseudomonas aeruginosa ATCC 90274 with a minimum inhibitory concentration (MIC) of 3.9 μg/ml and minimum bactericidal concentration (MBC) of 15.6 μg/ml, for both pathogens. Also, PsEAE exerts a significant inhibition on the biofilm formation of the previously mentioned pathogenic strains. In addition, we evaluated the wound healing efficiency of PsEAE on earthworms (Lumbricus castaneus) as a feasible and plausible model that mimics human skin. Interestingly, PsEAE exhibited a promising wound healing activity and enhanced wound closure. In conclusion, Paecilomyces sp. (AUMC 15510) could be a sustainable source of antimicrobial agents and a potential therapeutic target for wound management.

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Investigation on wound healing effect of Mediterranean medicinal plants and some related phenolic compounds: A review

Cited by 38 publications

References 271 publications

Natural Compounds and Biopolymers-Based Hydrogels Join Forces to Promote Wound Healing

Natural Compounds and Biopolymers-Based Hydrogels Join Forces to Promote Wound Healing

Effects of Stelechocarpus burahol [Blume] Leaf Ethanol Extract Ointment on Burns Healing

The antimicrobial, antibiofilm, and wound healing properties of ethyl acetate crude extract of an endophytic fungus Paecilomyces sp. (AUMC 15510) in earthworm model

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