Investigation on vitamin e succinate based intelligent hyaluronic acid micelles for overcoming drug resistance and enhancing anticancer efficacy

Hou, Lin; Tian, Chunyu; Chen, Dandan; Yuan, Yujie; Yan, Yingshan; Huang, Qian‐Xiao; Zhang, Huijuan; Zhang, Zhenzhong

doi:10.1016/j.ejps.2019.105071

Cited by 22 publications

(10 citation statements)

References 27 publications

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“…The TPGS (D-α-tocopherol acid polyethylene glycol succinate) is a water-soluble vitamin E derivative. Recent evidences suggest that the TPGS could reverse the MDR by inhibiting the ATPase activity without the influence of intracellular adenosine 5′-triphophagte (ATP) or mitochondrial function (Hou et al., 2019 ). Considering that the TPGS is an excellent nonionic surfactant, it could be used to stabilize and modify several nanoparticles.…”

Section: Circumventing the Drug-resistant Cancer Cell Drug Effluxmentioning

confidence: 99%

“…Hou et al. conjugated HA with vitamin E succinate as self-assemble micelles for reversing MDR, which not only achieve CD44 receptor overexpressing tumor targeting but also retain the inhibition of P-gp (Hou et al., 2019 ). Docosahexaenoic acid (DHA) is one of the w-3 unsaturated fatty acid and can chemosensitize MDR.…”

Section: Circumventing the Drug-resistant Cancer Cell Drug Effluxmentioning

confidence: 99%

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Recent advances in anti-multidrug resistance for nano-drug delivery system

Wang

Zhang

et al. 2022

Drug Delivery

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Chemotherapy for tumors occasionally results in drug resistance, which is the major reason for the treatment failure. Higher drug doses could improve the therapeutic effect, but higher toxicity limits the further treatment. For overcoming drug resistance, functional nano-drug delivery system (NDDS) has been explored to sensitize the anticancer drugs and decrease its side effects, which are applied in combating multidrug resistance (MDR) via a variety of mechanisms including bypassing drug efflux, controlling drug release, and disturbing metabolism. This review starts with a brief report on the major MDR causes. Furthermore, we searched the papers from NDDS and introduced the recent advances in sensitizing the chemotherapeutic drugs against MDR tumors. Finally, we concluded that the NDDS was based on several mechanisms, and we looked forward to the future in this field.

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Section: Circumventing the Drug-resistant Cancer Cell Drug Effluxmentioning

confidence: 99%

Section: Circumventing the Drug-resistant Cancer Cell Drug Effluxmentioning

confidence: 99%

Recent advances in anti-multidrug resistance for nano-drug delivery system

Wang

Zhang

et al. 2022

Drug Delivery

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“…(2020) Hyaluronic acid PTX-loaded D-α-tocopheryl polyethylene glycol succinate micelles The micelles exhibited high internalization and cytotoxicity in MCF-7/ADR cells in vitro and in vivo . Hou et al. (2019) Transferrin receptor 1-mediated endocytosis 7pep Transferrin receptor-1-targeted 7pep-conjugated hybrid peptide composed of an extracellular signal-regulated kinase inhibitor The conjugate demonstrated high selectivity for tumor cells, with 72.2 ± 4.6% inhibition in the xenografts in vivo .…”

Section: Ligands Used To Target Carriers To Mdr Bc Cellsmentioning

confidence: 99%

“… (M. Liu et al., 2020 ) TPGS PTX Reduction-sensitive hyaluronic acid conjugated TPGS micelles MCF-7/ADR drug-resistant BC cell line in vitro and in vivo The micelles demonstrated 21.05% and 72.7% PTX release in 48 h in the medium without and with 20 mM glutathione, respectively. Hou et al. (2019) DOX = doxorubicin; PTX = paclitaxel; QUE = paclitaxel; TPGS = tocopheryl poly (ethylene glycol) 1000 succinate.…”

Section: Tumor Microenvironment Responsive Targeted Drug Deliverymentioning

confidence: 99%

Exploring new Horizons in overcoming P-glycoprotein-mediated multidrug-resistant breast cancer via nanoscale drug delivery platforms

Famta

Shah

Chatterjee

et al. 2021

Current Research in Pharmacology and Drug Discovery

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The high probability (13%) of women developing breast cancer in their lifetimes in America is exacerbated by the emergence of multidrug resistance after exposure to first-line chemotherapeutic agents. Permeation glycoprotein (P-gp)-mediated drug efflux is widely recognized as the major driver of this resistance. Initial in vitro and in vivo investigations of the co-delivery of chemotherapeutic agents and P-gp inhibitors have yielded satisfactory results; however, these results have not translated to clinical settings. The systemic delivery of multiple agents causes adverse effects and drug–drug interactions, and diminishes patient compliance. Nanocarrier-based site-specific delivery has recently gained substantial attention among researchers for its promise in circumventing the pitfalls associated with conventional therapy. In this review article, we focus on nanocarrier-based co-delivery approaches encompassing a wide range of P-gp inhibitors along with chemotherapeutic agents. We discuss the contributions of active targeting and stimuli responsive systems in imparting site-specific cytotoxicity and reducing both the dose and adverse effects.

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“…Currently, various nanocarriers have been made for the delivery of anticancer drugs to enhance targetability, lipophilicity, stability, and biocompatibility, and to overcome multidrug resistance, including polymer nanomicelles [ 17 ], nanocapsules [ 18 ], nanoliposomes [ 19 ], and nanoemulsions [ 20 ]. Among them, polymer nanomicelles have become a potential anticancer drug carrier because of their outstanding drug loading, long blood circulation, enhanced permeability and retention (EPR).…”

Section: Introductionmentioning

confidence: 99%

Oleic Acid Copolymer as A Novel Upconversion Nanomaterial to Make Doxorubicin-Loaded Nanomicelles with Dual Responsiveness to pH and NIR

et al. 2020

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Oleic acid (OA) as main component of plant oil is an important solvent but seldom used in the nanocarrier of anticancer drugs because of strong hydrophobicity and little drug release. In order to develop a new type of OA nanomaterial with dual responses to pH and near infrared light (NIR) to achieve the intelligent delivery of anticancer drugs. The novel OA copolymer (mPEG-PEI-(NBS, OA)) was synthesized by grafting OA and o-nitrobenzyl succinate (NBS) onto mPEGylated polyethyleneimine (mPEG-PEI) by amidation reaction. It was further conjugated with NaYF4:Yb3+/Er3+ nanoparticles, and encapsulated doxorubicin (DOX) through self-assembly to make upconversion nanomicelles with dual response to pH and NIR. Drug release behavior of DOX, physicochemical characteristics of the nanomicelles were evaluated, along with its cytotoxic profile, as well as the degree of cellular uptake in A549 cells. The encapsulation efficiency and drug loading capacity of DOX in the nanomicelles were 73.84% ± 0.58% and 4.62% ± 0.28%, respectively, and the encapsulated DOX was quickly released in an acidic environment exposed to irradiation at 980 nm. The blank nanomicelles exhibited low cytotoxicity and excellent biocompatibility by MTT assay against A549 cells. The DOX-loaded nanomicelles showed remarkable cytotoxicity to A549 cells under NIR, and promoted the cellular uptake of DOX into the cytoplasm and nucleus of cancer cells. OA copolymer can effectively deliver DOX to cancer cells and achieve tumor targeting through a dual response to pH and NIR.

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Investigation on vitamin e succinate based intelligent hyaluronic acid micelles for overcoming drug resistance and enhancing anticancer efficacy

Cited by 22 publications

References 27 publications

Recent advances in anti-multidrug resistance for nano-drug delivery system

Recent advances in anti-multidrug resistance for nano-drug delivery system

Exploring new Horizons in overcoming P-glycoprotein-mediated multidrug-resistant breast cancer via nanoscale drug delivery platforms

Oleic Acid Copolymer as A Novel Upconversion Nanomaterial to Make Doxorubicin-Loaded Nanomicelles with Dual Responsiveness to pH and NIR

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