Investigation on the Toxin Production by Several Blast Fungus Strains and Isolation of Tenuazonic Acid as a Novel Toxin

Umetsu, Noriharu; Kaji, Jun; Tamari, Kinjirô

doi:10.1271/bbb1961.36.859

Cited by 38 publications

(20 citation statements)

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“…Its biological activity was first described by Shigeura and Gordon [153]. Later, it was isolated from Magnaporthe grisea (the blast fungus, former name is Pyricularia oryzae) as a phytotoxin [154] and from Alternaria longiceps, A. kikuchiana, A. mali, A. alternata, A. tenuissima and Phoma sorghina as a mycotoxin [155][156][157][158][159]. Additionally, TA has been made responsible for the outbreak of "onyalai" a human hematologic disorder disease occurring in Africa after consumption of sorghum [159].…”

Section: Historical Perspective and Tautomeric Formulaementioning

confidence: 99%

Mycotoxins: Producing Fungi and Mechanisms of Phytotoxicity

2015

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Abstract:Mycotoxins are secondary fungal metabolites, toxic to humans, animals and plants. Among the hundreds of known mycotoxins, aflatoxins, citrinin, patulin, penicillic acid, tenuazonic acid, ochratoxin A, cytochalasins, deoxynivalenol, fumonisins, fusarin C, fusaric acid, and zearalenone are considered the types that most contaminate cereal grain. The majority of the mycotoxins in these groups are produced by three fungal genera: Aspergillus, Penicillium and Fusarium. These metabolites primarily affect the seed quality, germination, viability, seedling vigour, growth of root and cleoptile. Additionally, since the fungi responsible for the production of these mycotoxins are often endophytes that infect and colonize living plant tissues, accumulation of mycotoxins in the plant tissues may at times be associated with development of plant disease symptoms. The presence of mycotoxins, even in the absence of disease symptoms, may still have subtle biological effects on the physiology of plants. Several studies highlight the toxic effects of mycotoxins on animals and cell lines but little is known about the mode of action of most of these metabolites on plant cells. The most important mycotoxins with phytotoxic effects and their producers in addition to their discovery are briefly outlined below and will be addressed in this article.

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Section: Historical Perspective and Tautomeric Formulaementioning

confidence: 99%

Mycotoxins: Producing Fungi and Mechanisms of Phytotoxicity

2015

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“…Furthermore, IR spectrum agreed with that of authentic T.A. 3 ) Then, quantitative estimation of T.A. in diseased rice plants was made by measurement of the UV absorbance at 278 mfl in the eluate from the zone of TA.…”

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confidence: 52%

“…Recently Iwasaki et al 2 ) isolated pyriculol from the culture broth of blast fungus. More recently, we 3 ) and Iwasaki et al 4 ) isolated tenuazonic acid (T.A.) from the culture broth of blast fungus.…”

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confidence: 99%

Isolation of Tenuazonic Acid from Blast-diseased Rice Plants

Umetsu

Kaji

Tamari

1973

Agricultural and Biological Chemistry

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“…Pyricuol, a rice blast disease toxin Rice blast disease, which is caused by infection with the rice blast fungus, Magnaporthe grisea (imperfect stage of Pyricularia oryzae Cavara), is the most serious pest for rice. 19) To date, several salicylaldehyde-type pathogenic compounds have been isolated from the To whom correspondence should be addressed. Tel: +81-22-717-8785; Fax: +81-22-717-8783; E-mail: kiyota@biochem.tohoku.ac.jp Biosci.…”

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confidence: 99%