Investigation on the thermal behavior of β-blockers antihypertensives atenolol and nadolol using TG/DTG, DTA, DSC, and TG–FTIR

Amorim, Pedro Henrique Oliveira; Ferreira, Ana Paula Garcia; Machado, Luis Carlos M.; Cervini, Priscila; Cavalheiro, Éder Tadeu Gomes

doi:10.1007/s10973-014-4357-3

Cited by 21 publications

(4 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…TG-FTIR is widely used to analyze the gaseous products during the thermal decomposition [12,23,24]. The three-dimensional diagrams of infrared absorption of evolved gas products versus time and wavenumber during the thermal decomposition processes are shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

Study on the thermal decomposition of capecitabine

Wang

You

2015

J Therm Anal Calorim

View full text Add to dashboard Cite

The thermal decomposition of capecitabine (CAP) was measured with thermogravimetry, differential scanning calorimetry, and thermogravimetric analysis coupled with Fourier transform infrared spectroscopy. The IR spectra, high-performance liquid chromatography, and liquid chromatography-mass spectrometry of CAP and the residue of its thermal decomposition at various temperatures were determined. The molecular bond orders were calculated using an ab initio method from the GAMESS program of quantum chemistry. The mode of thermal decomposition for CAP was discussed. The kinetic parameters for thermal decomposition such as activation energy E a and the pre-exponential factor A were obtained using the Ozawa method. The prospective lifetime of CAP was estimated using the Dakin equation. The results indicated that the thermal decomposition of CAP is a three-step process, and the first mass loss stage is to lose pentyl formate. The initial decomposition temperature in either nitrogen or air is 120°C. For decomposition in nitrogen, the E a and A for the initial thermal decomposition are 105.1 kJ mol -1 and 9.12 9 10 11 min -1 , respectively. For decomposition in air, the corresponding E a and A are 105.1 kJ mol -1 and 9.55 9 10 11 min -1 , respectively. The CAP has poor thermal stability under routine temperature.

show abstract

Section: Resultsmentioning

confidence: 99%

Study on the thermal decomposition of capecitabine

Wang

You

2015

J Therm Anal Calorim

View full text Add to dashboard Cite

show abstract

“…A comparison of the DSC curves from the first and second heating reveals potential differences in these curves. If the DSC curves for the first and second heating are the same, this indicates that the sample remained stable throughout the DSC procedure [10,11]. Therefore, the purpose of the present work was to assess the usefulness of the heating-cooling-reheating program in detecting potential incompatibilities between atenolol and polymeric excipients.…”

Section: Introductionmentioning

confidence: 99%

Quantification of Compatibility Between Polymeric Excipients and Atenolol Using Principal Component Analysis and Hierarchical Cluster Analysis

2021

View full text Add to dashboard Cite

An important challenge to overcome in the solid dosage forms technology is the selection of the most biopharmaceutically efficient polymeric excipients. The excipients can be selected, among others, by compatibility studies since incompatibilities between ingredients of the drug formulations adversely affect their bioavailability, stability, efficacy, and safety. Therefore, new, fast, and reliable methods for detecting incompatibility are constantly being sought. Hence, the purpose of this work was to assess the usefulness of a heating, cooling, and reheating differential scanning calorimetry (DSC) program for detecting potential incompatibilities between atenolol, an active pharmaceutical ingredient (API), and polymeric excipients. Hot-stage microscopy (HSM), Fourier transform infrared (FTIR) spectroscopy, and powder X-ray diffraction (PXRD) were used as supporting techniques. Additionally, principal component analysis (PCA) and hierarchical cluster analysis (HCA) served as tools to support the interpretation of the data acquired from the DSC curves and FTIR spectra. As the alterations in the shape of the DSC peak of atenolol which are indicative of incompatibility are visible only on the cooling and reheating curves of the mixtures, the DSC heating–cooling–reheating program was found to be very useful for identifying potential incompatibilities in the binary mixtures of atenolol and polymeric excipients. The melting and recrystallization of atenolol alone and in its mixtures were also confirmed by HSM, while FTIR displayed changes in the spectra of mixtures due to incompatibility. These studies revealed that atenolol is incompatible with hydroxyethylcellulose, hypromellose, and methylcellulose. PXRD measurements at room temperature revealed that the crystallinity of atenolol did not change in these mixtures. However, its crystallinity was reduced in the mixtures previously heated up to 155 °C and then cooled to 25 °C. Graphical abstract

show abstract

“…Thermogravimetry-differential scanning calorimetry coupled with Fourier transform infrared spectroscopy and quadrupole mass spectroscopy (TG/DSC/FTIR/QMS) is an important and often used analysis tool in order to evaluate both thermal stability and the decomposition mechanism of many different structure compounds [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. Many researches and engineers applied this analysis method to their studies because it allowed evaluating not only the thermal resistance of the various materials but also the type of the decomposition gaseous products emitted under heating or burning the materials.…”

Section: Introductionmentioning

confidence: 99%

“…In addition by the analysis of the type of the volatile decomposition products emitted under heating of the materials, it is possible to evaluate the decomposition course and the most probable decomposition mechanism of organic, inorganic and polymeric materials. Such knowledge is basic in many practical applications where the materials are subjected to high temperatures [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. Most of the materials which have practical applications are manufactured, utilized and converted under the access of oxygen.…”

Section: Introductionmentioning

confidence: 99%

TG/DSC/FTIR/QMS studies on the oxidative decomposition of terpene acrylate homopolymers

Worzakowska

2016

J Therm Anal Calorim

View full text Add to dashboard Cite

The oxidative thermal stability along with the identification of the volatile decomposition products under heating of terpene acrylate homopolymers by using TG/ DSC/FTIR/QMS-coupled method was presented. It was found that the decomposition of poly(geranyl acrylate) and poly(neryl acrylate) had quite different course as compared to the decomposition process of poly(citronellyl acrylate) under oxidative conditions. FTIR and QMS analyses confirmed mainly the formation of terpene hydrocarbons, propane, propene, acetic acid, CO, CO 2 and H 2 O as the volatile decomposition products under heating of the hompolymers. The results obtained indicated the complex decomposition process of terpene acrylate homopolymers including the random ester bond scissors, the random main carbon chain scissors, decarboxylation, dehydration and oxidation processes of formed gaseous decomposition products and a residue which led to the full decomposition of homopolymers at ca. 600°C under oxidative conditions. Keywords Poly(geranyl acrylate) Á Poly(neryl acrylate) Á Poly(citronellyl acrylate) Á TG/DSC/FTIR/QMS

show abstract

Investigation on the thermal behavior of β-blockers antihypertensives atenolol and nadolol using TG/DTG, DTA, DSC, and TG–FTIR

Cited by 21 publications

References 17 publications

Study on the thermal decomposition of capecitabine

Study on the thermal decomposition of capecitabine

Quantification of Compatibility Between Polymeric Excipients and Atenolol Using Principal Component Analysis and Hierarchical Cluster Analysis

TG/DSC/FTIR/QMS studies on the oxidative decomposition of terpene acrylate homopolymers

Contact Info

Product

Resources

About