Investigation on the self-assembly of the NFL-TBS.40-63 peptide and its interaction with gold nanoparticles as a delivery agent for glioblastoma

Ali, H Alnemeh-Al; Griveau, Audrey; Artzner, Franck; Dupont, Aurélien; Lautram, Nolwenn; Jourdain, M A; Eyer, Joël

doi:10.1016/j.ijpx.2022.100128

Cited by 3 publications

(2 citation statements)

References 47 publications

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“…They also revealed that the anti-tumor effect on GBM cells was boosted by BIOT-NFL-gold nanoparticles. 109…”

Section: Nanomedicine Role and Mechanism In The Treatment Of Glioblas...mentioning

confidence: 99%

“…Notch1 moves into the nucleus, activating its downstream pathway, increasing proliferation, and inhibiting apoptosis, which are two characteristics of cancer. 62,63 Notch1 is typically increased in glioma samples and glioblastoma cell lines, while Notch2 appears to be down-regulated. In GBM cells, Notch1 is knocked down by siRNAs, which inhibit cell growth and invasion and induce apoptosis.…”

Section: Notch Pathwaymentioning

confidence: 99%

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Nanomedicine facilitated cell signaling blockade: difficulties and strategies to overcome glioblastoma

Habeeb,

Vengateswaran,

You

et al. 2024

J. Mater. Chem. B

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“…They also revealed that the anti-tumor effect on GBM cells was boosted by BIOT-NFL-gold nanoparticles. 109…”

Section: Nanomedicine Role and Mechanism In The Treatment Of Glioblas...mentioning

confidence: 99%

Section: Notch Pathwaymentioning

confidence: 99%

Nanomedicine facilitated cell signaling blockade: difficulties and strategies to overcome glioblastoma

Habeeb,

Vengateswaran,

You

et al. 2024

J. Mater. Chem. B

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Investigating the functionalization of liposomes with NFL-TBS. 40-63 peptide as a promising drug delivery system

Jourdain,

Dupont,

Lautram

et al. 2024

International Journal of Pharmaceutics

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The association between cadmium exposure and axonal injury biomarker, serum neurofilament light chain levels in US adults

Luo,

Lin

2024

Preprint

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Background and Aims: Cadmium exposure has been shown a toxic effect on the nervous system, but little is known regarding the link between cadmium exposure and axonal injury. Therefore, we aim to investigate whether there is a relationship between blood cadmium and serum neurofilament light chain (NfL) levels in the general population. Methods and Results: In the National Health and Nutrition Examination Survey 2013–2014, 1,040 participants with a median (IQR) age of 47 (35–60) years are enrolled. Serum NfL levels are measured using a highly sensitive immunoassay. Whole blood cadmium concentrations are detected using inductively coupled plasma mass spectrometry. Linear regression and restricted cubic spline models are used to analyze the strength and shape of the relationship between blood cadmium and serum NfL levels. In full adjusted model, blood cadmium levels are positively associated with serum NfL levels (Q4 vs Q1, β = 3.35, 95%CI: 0.41, 6.30, p for trend = 0.014). A potential linear positive dose-effect relationship is found between blood cadmium and serum NfL levels (p for non-linearity = 0.15), and the potential threshold dose of blood cadmium is 0.7 µg/L. The stratified analysis shows a significant positive relationship between blood cadmium and serum NfL levels is limited to middle-aged and older adults. Conclusion: The present study suggests a positive association between blood cadmium and serum NfL levels in the general US population. This study is expected to provide new ideas for the primary prevention and mechanism exploration of neurodegenerative diseases.

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Investigation on the self-assembly of the NFL-TBS.40-63 peptide and its interaction with gold nanoparticles as a delivery agent for glioblastoma

Cited by 3 publications

References 47 publications

Nanomedicine facilitated cell signaling blockade: difficulties and strategies to overcome glioblastoma

Nanomedicine facilitated cell signaling blockade: difficulties and strategies to overcome glioblastoma

Investigating the functionalization of liposomes with NFL-TBS. 40-63 peptide as a promising drug delivery system

The association between cadmium exposure and axonal injury biomarker, serum neurofilament light chain levels in US adults

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