Investigation on the role of Spirulina platensis in ameliorating behavioural changes, thyroid dysfunction and oxidative stress in offspring of pregnant rats exposed to fluoride

Banji, David; Banji, Otilia J.F.; Pratusha, N. Gouri; Annamalai, A.R.

doi:10.1016/j.foodchem.2013.02.076

Cited by 71 publications

(38 citation statements)

References 58 publications

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“…The nephroprotective effects of SP have been reported against renal injury induced by gentamicin [27], [57] as well as oxalate [58]–[59]. Moreover, the antioxidant effects of SP have been reported against sodium fluoride-induced oxidative alterations in offspring of pregnant rats [60]. In another study, SP fed pregnant rats' alleviated lead-induced brain damage in newborns [61].…”

Section: Discussionmentioning

confidence: 95%

Protective Role of Spirulina platensis against Acute Deltamethrin-Induced Toxicity in Rats

2013

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Deltamethrin is a broad-spectrum synthetic pyrethroid insecticide and acaricide widely used for agricultural and veterinary purposes. However, its human and animal exposure leads to hepatonephrotoxicity. Therefore, the present study was undertaken to examine the hepatonephroprotective and antioxidant potential of Spirulina platensis against deltamethrin toxicity in male Wistar albino rats. Deltamethrin treated animals revealed a significant increase in serum biochemical parameters as well as hepatic and renal lipid peroxidation but caused an inhibition in antioxidant biomarkers. Spirulina normalized the elevated serum levels of AST, ALT, APL, uric acid, urea and creatinine. Furthermore, it reduced deltamethrin-induced lipid peroxidation and oxidative stress in a dose dependent manner. Therefore, it could be concluded that spirulina administration able to minimize the toxic effects of deltamethrin by its free radical-scavenging and potent antioxidant activity.

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Section: Discussionmentioning

confidence: 95%

Protective Role of Spirulina platensis against Acute Deltamethrin-Induced Toxicity in Rats

2013

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“…Amidst concerns related to cyanobacteria spp. and neurodegenerative diseases, it is worth pointing out that spirulina has been the subject of a number of studies related to the brain and nervous system, with outcomes demonstrating benefit even in models of developmental origins of health and disease [29-33]. For example, oral spirulina administration has been shown to protect against experimentally-induced neural tube defects [34] and spirulina-enhanced diets afford neuroprotection in experimental models of Parkinson’s disease [35].…”

Section: Resultsmentioning

confidence: 99%

Analysis of β-N-methylamino-L-alanine (BMAA) in spirulina-containing supplements by liquid chromatography-tandem mass spectrometry

McCarron

Logan²,

Giddings

et al. 2014

Aquat. Biosyst.

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Over the last decade the amino acid beta-N-methylamino-L-alanine (BMAA) has come under intense scrutiny. International laboratory and epidemiological research continues to support the hypothesis that environmental exposure to BMAA (e.g., through dietary practices, water supply) can promote the risk of various neurodegenerative diseases. A wide variety of cyanobacteria spp. have previously been reported to produce BMAA, with production levels dependent upon species, strain and environmental conditions. Since spirulina (Arthrospira spp.) is a member of the cyanobacteria phylum frequently consumed via dietary supplements, the presence of BMAA in such products may have public health implications. In the current work, we have analyzed ten spirulina-containing samples for the presence of BMAA; six pure spirulina samples from two separate raw materials suppliers, and four commercially-available multi-ingredient products containing 1.45 g of spirulina per 8.5 g serving. Because of controversy surrounding the measurement of BMAA, we have used two complementary liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods: one based on reversed phase LC (RPLC) with derivatization and the other based on hydrophilic interaction LC (HILIC). Potential matrix effects were corrected for by internal standardization using a stable isotope labeled BMAA standard. BMAA was not detected at low limits of detection (80 ng/g dry weight) in any of these product samples. Although these results are reassuring, BMAA analyses should be conducted on a wider sample selection and, perhaps, as part of ongoing spirulina production quality control testing and specifications.

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“…Decreased locomotor performance due to altered central cholinergic mechanisms was observed [42]. Earlier reports on natural products which aid in protection against NaFinduced behavioral alterations are: Curcumin -improve thermal (on hot plate test) and mechanical (on Randall and Selitto) pain response [43], Quercetin -helps in better learning abilities and memory (with maze task) [3], Rutin (extracted compound of okra) -helps in enhanced motor coordination (Rotarod treadmill test) [44], vitamin A -better rotarod performance and learning abilities [7], and Spirulina platensis -aid in motor coordination and better performance with maze task [45]. These natural products reverse behavioral alterations which are induced on NaF exposure.…”

Section: Congo Red Stainmentioning

confidence: 99%

Seed Extract of Abelmoschus Moschatus Medik Reverses Naf-Induced Behavioral Changes Through Neurodegeneration and Oxidative Stress in Brain of Rat

Sudhakar

Mesram

2017

Asian J Pharm Clin Res

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Objective: This study reports protective effect of Abelmoschus moschatus seed extract against sodium fluoride-induced neurodegeneration through oxidative stress, neurohistological, and behavioral observations in Wistar rats.Methods: A total of 20 Wistar rats (around 250 g) were randomly classified into four groups, namely, control, fluoride (NaF), fluoride + A. moschatus seed aqueous extract (AMAE), and fluoride + A. moschatus seed ethanol extract (AMEE). The control group animals received normal tap water, fluoride group received fluoridated water at the rate of 40 mg/kg b. wt., 3rd group rats treated with fluoride (40 mg/kg b. wt.) + AMAE (300 mg/kg b. wt.), and 4th group rats treated with fluoride (40 mg/kg b. wt.) + AMEE (300 mg/kg b. wt.). Neurobehavioral responses of rotarod, hot plate, and maze learning tests and oxidantive stress markers including lipid peroxidation (LPO), GSH levels, superoxide dismutase, CAT, and GSH peroxidase (GPx) activities, and also histology with H and E as well as congo red staining were studied in control, fluoride, and A. moschatus seed extract treated against fluoride groups.Results: Decreased neurobehavioral responses with rotarod, hot plate, and maze and enhanced LPO (p<0.05) levels were found in fluoride received animals. Whereas, the superoxide dismutase (SOD), CAT, GSH, and GPx were decreased (p<0.05) in NaF treatment. The rats received seed extract along with NaF showed significant reversal of behavioral and oxidative stress markers and the effect of ethanol extract was more pronounced than aqueous extract. The fluoride-treated group showed disturbed cell structure and reduced number of cells in H and E as well as congo red staining which was reversed in cell morphology and restored cell number in seed extract against NaF-treated group. As a result of increased LPO, decreased antioxidant system, and decreased number of cells, neurodegeneration was observed resulting in the disturbance in functions associated with reported behavior.Conclusion: Okra with high antioxidants activity, seed extract showed reversal of LPO levels and antioxidant status in the brain tissue. And also plant extract administered rats displayed normal cell structure and number of cells than only fluoride received group. Therefore, the aqueous and ethanolic extract of A. moschatus plant seeds has neuroprotective effects against fluoride-induced motor, nociceptive, learning behavior, and on histological structure of brain through antioxidant mechanism. The ethanol extract has shown more efficacy than aqueous extract.

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Investigation on the role of Spirulina platensis in ameliorating behavioural changes, thyroid dysfunction and oxidative stress in offspring of pregnant rats exposed to fluoride

Cited by 71 publications

References 58 publications

Protective Role of Spirulina platensis against Acute Deltamethrin-Induced Toxicity in Rats

Protective Role of Spirulina platensis against Acute Deltamethrin-Induced Toxicity in Rats

Analysis of β-N-methylamino-L-alanine (BMAA) in spirulina-containing supplements by liquid chromatography-tandem mass spectrometry

Seed Extract of Abelmoschus Moschatus Medik Reverses Naf-Induced Behavioral Changes Through Neurodegeneration and Oxidative Stress in Brain of Rat

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