Investigation on the mechanisms by which the herbal remedies induce anti-prostate cancer activity: uncovering the most practical natural compound

Poustforoosh, Alireza; Faramarz, Sanaz; Negahdaripour, Manica; Tüzün, Burak; Hashemipour, Hassan

doi:10.1080/07391102.2023.2213344

Cited by 7 publications

(1 citation statement)

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“…The complex system obtained from the docking calculation was used for the MD [ 29 ]. The simulation was performed in an orthorhombic box, and the solvent model of transferable intermolecular potential with 3 points (TIP3P) was chosen for the simulation [ 30 ]. The proper number of Na+/Cl− ions with a salt concentration of 0.15 M was used to neutralize the system employing the system setup of Schrödinger [ 31 ].…”

Section: Methodsmentioning

confidence: 99%

Comparison of Protective Effects of Phenolic Acids on Protein Glycation of BSA Supported by In Vitro and Docking Studies

Rashedinia,

Rasti Arbabi,

Sabet

et al. 2023

Biochemistry Research International

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Several diabetic complications are associated with forming advanced glycation end products (AGEs). Different chemical and natural compounds are able to prevent the development of these products. In this study, glycosylation was induced as a model by incubating bovine serum albumin (BSA) with glucose. Consequently, BSA was treated with glucose and different concentrations (1.25, 2.5, and 5 μM) of syringic acid, gallic acid, ellagic acid, ferulic acid, paracoumaric acid, and caffeic acid for 4 and 6 weeks. Biochemical experiments comprise measurements of fluorescent AGEs, protein carbonyl contents, total thiol, hemolysis tests, and also malondialdehyde (MDA) levels in RBC. These demonstrated the antiglycating mechanism of these phenolic acids. Most of the phenolic acids used in this study reduced MDA levels and protected thiol residues in protein structures. They also inhibited the formation of fluorescent AGEs and RBC lysis, except gallic acid. Moreover, ferulic acid, paracoumaric acid, and caffeic acid proteins significantly prevent carbonylation. Molecular docking and simulation studies showed that ellagic, caffeic, gallic, and syringic acids could interact with lysine and arginine residues in the active site of BSA and stabilize its structure to inhibit the formation of AGEs. Our results suggest that phenolic acid could be used as a potential phytochemical against protein glycation and related diabetic complications.

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Section: Methodsmentioning

confidence: 99%