Investigation on the immunomodulatory activities of Sarcodon imbricatus extracts in a cyclophosphamide (CTX)-induced immunosuppressanted mouse model

Meng, Fanjuan; Xu, Panju; Wang, Xue; Huang, Yu Chen; Wu, Laijun; Teng, Lirong; Wang, Di

doi:10.1016/j.jsps.2017.04.006

Cited by 38 publications

(24 citation statements)

References 33 publications

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“…Cy is an important alkylating agent used in cancer treatment and blood and marrow transplantation [21]. However, the administration of Cy can lead to immunosuppression and hepatotoxicity that is reflected in lower body weight and spleen and thymus indices, disruption of the intestinal mucosal immunity, liver dysfunction, and oxidative stress [22,23]. Thus, Cy was used to creating the immunosuppressed animal model in this study.…”

Section: Discussionmentioning

confidence: 99%

Treatment with Subcritical Water-Hydrolyzed Citrus Pectin Ameliorated Cyclophosphamide-Induced Immunosuppression and Modulated Gut Microbiota Composition in ICR Mice

et al. 2020

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Subcritical water can effectively hydrolyze pectin into smaller molecules while still maintaining its functional regions. Pectic heteropolysaccharide can mediate immune regulation; however, the possible effects of subcritical water-hydrolyzed citrus pectin (SCP) on the immune response remain unclear. Therefore, the effects of SCP on immunomodulatory functions and intestinal microbial dysbiosis were investigated using a cyclophosphamide-induced immunosuppressed mouse model. In this research, immunosuppressed ICR mice were administrated with SCP at dosages of 300/600/1200 mg/kg.bw by oral gavage, and body weight, immune organ indexes, cytokines, and gut microbiota were determined. The results showed that subcritical water treatment decreased the molecular mass and increased the content of galacturonic acid in citrus pectin hydrolysates. Meanwhile, the treatment with SCP improved immunoregulatory functional properties and bioactivities over the original citrus pectin. For example, SCP protected immune organs (accelerated recovery of immune organ indexes) and significantly enhanced the expression of immune-related cytokines (IL-2, IL-6, IFN-γ, and TNF-α). The results of the 16S rDNA sequencing analysis on an IlluminaMiSeq platform showed that SCP normalized Cy-induced gut dysbiosis. SCP ameliorated Cy-dependent changes in the relative abundance of several taxa, shifting the balance back to normal status (e.g., SCP increased beneficial Muribaculaceae, Ruminococcaceae, Bacteroidaceae, and Prevotellaceae while decreasing pathogenic Brevundimonas and Streptococcus). The results of this study suggest an innovative application of citrus pectin as an immunomodulator.

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Section: Discussionmentioning

confidence: 99%

Treatment with Subcritical Water-Hydrolyzed Citrus Pectin Ameliorated Cyclophosphamide-Induced Immunosuppression and Modulated Gut Microbiota Composition in ICR Mice

et al. 2020

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“…Sarcodon imbricatus (L.) P. Karst, belonging to the family Bankeraceae, is an edible fungus occurring in China, Thailand, and Turkey [4,58,215]. It is widely used in Asian medicine [216]. An investigation on a polysaccharide-enriched extract of S. imbricatus revealed that it stimulates the immune response in CTX-induced immunosuppressed mice via modulation of oxidative pathways [216].…”

Section: Sarcodon Imbricatus (L) P Karstmentioning

confidence: 99%

“…It is widely used in Asian medicine [216]. An investigation on a polysaccharide-enriched extract of S. imbricatus revealed that it stimulates the immune response in CTX-induced immunosuppressed mice via modulation of oxidative pathways [216]. An extract of S. imbricatus exhibited the growth of gram-negative and gram-positive bacteria [22,217].…”

Section: Sarcodon Imbricatus (L) P Karstmentioning

confidence: 99%

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Bioactive Phytochemical Constituents of Wild Edible Mushrooms from Southeast Asia

et al. 2020

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Mushrooms have a long history of uses for their medicinal and nutritional properties. They have been consumed by people for thousands of years. Edible mushrooms are collected in the wild or cultivated worldwide. Recently, mushroom extracts and their secondary metabolites have acquired considerable attention due to their biological effects, which include antioxidant, antimicrobial, anti-cancer, anti-inflammatory, anti-obesity, and immunomodulatory activities. Thus, in addition to phytochemists, nutritionists and consumers are now deeply interested in the phytochemical constituents of mushrooms, which provide beneficial effects to humans in terms of health promotion and reduction of disease-related risks. In recent years, scientific reports on the nutritional, phytochemical and pharmacological properties of mushroom have been overwhelming. However, the bioactive compounds and biological properties of wild edible mushrooms growing in Southeast Asian countries have been rarely described. In this review, the bioactive compounds isolated from 25 selected wild edible mushrooms growing in Southeast Asia have been reviewed, together with their biological activities. Phytoconstituents with antioxidant and antimicrobial activities have been highlighted. Several evidences indicate that mushrooms are good sources for natural antioxidants and antimicrobial agents

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“…Mushrooms are well‐known for their nutritional content and are predominantly consumed worldwide for their health and nutritional benefits. Scaly‐tooth mushroom, Sarcodon imbricatus (L.) P. Karsten, is a valuable edible mushroom known for its nutritional and medicinal values . This edible basidiomycete fungus belongs the Division: Basidiomycota, Class: Agaricomycetes, Order: Thelephorales and is commonly found symbiotic association with Norway spruce and pine widely distributed in north America and Europe.…”

Section: Introductionmentioning

confidence: 99%

Accumulation Pattern of Inorganic Elements in Scaly Tooth Mushroom (Sarcodon imbricatus) from Northern Poland

Saba

Falandysz

Loganathan

2020

Chemistry & Biodiversity

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Several studies have documented contamination levels and daily intake of metallic elements from foodstuffs including rice, maize, pulses, vegetables, fruits, fish, meat, egg, milk etc., however, limited literature is available on metal contamination levels in wild growing mushrooms and possible human exposure via consumption of it. Sarcodon imbricatus is an edible mushroom, commonly consumed in many parts of the world. Very few studies have been conducted on inorganic elemental composition in fruiting bodies (edible part) of this fungus. In this study, elements such as silver (Ag), aluminum (Al), barium (Ba), calcium (Ca), cadmium (Cd), cobalt (Co,) chromium (Cr), copper (Cu), iron (Fe), mercury (Hg), potassium (K), magnesium (Mg), manganese (Mn), sodium (Na), nickel (Ni), phosphorous (P), lead (Pb), rubidium (Rb), strontium (Sr) and zinc (Zn) were measured in caps and stems of fruiting bodies of S. imbricatus collected from the Wdzydze forests in Central and the Augustowska Primeval forest in Eastern Poland. Results revealed that a wide variation in concentrations of various metals in caps and stems samples collected from the two forests. Toxic metallic elements such as Cd and Hg showed preferential accumulation in caps than stems samples from both the forests. However, the concentrations of Cd, Hg and Pb in the mushroom samples were below the established weekly intake tolerance limits.

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Investigation on the immunomodulatory activities of Sarcodon imbricatus extracts in a cyclophosphamide (CTX)-induced immunosuppressanted mouse model

Cited by 38 publications

References 33 publications

Treatment with Subcritical Water-Hydrolyzed Citrus Pectin Ameliorated Cyclophosphamide-Induced Immunosuppression and Modulated Gut Microbiota Composition in ICR Mice

Treatment with Subcritical Water-Hydrolyzed Citrus Pectin Ameliorated Cyclophosphamide-Induced Immunosuppression and Modulated Gut Microbiota Composition in ICR Mice

Bioactive Phytochemical Constituents of Wild Edible Mushrooms from Southeast Asia

Accumulation Pattern of Inorganic Elements in Scaly Tooth Mushroom (Sarcodon imbricatus) from Northern Poland

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