Investigation on the effect of roller compaction on paracetamol

Tay, Justin Yong Soon; Han, Qi En; Liew, Celine Valeria; Heng, Paul Wan Sia

doi:10.1080/10837450.2019.1676783

Cited by 5 publications

(2 citation statements)

References 37 publications

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“…An indicator for granule hardening is the yield pressure derived from Heckel analysis of the tableting data [ 31 , 32 , 33 ], as it is a parameter describing the material‘s ability to plastically deform. When granule hardening occurs, the material is less prone to plastically deform, and therefore an increase in yield pressure would be expected.…”

Section: Resultsmentioning

confidence: 99%

“…The yield pressure Py is the reciprocal of K and is commonly used to describe a powder’s viscoelastic behavior. Additionally, it is an indicator for the granule hardening phenomenon, one of the explanations for the loss in tabletability after roller compaction [ 31 , 32 , 33 ]. For this study, the Heckel yield pressure was determined with in-die tableting data ( n = 10).…”

Section: Methodsmentioning

confidence: 99%

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Understanding the Multidimensional Effects of Polymorphism, Particle Size and Processing for D-Mannitol Powders

et al. 2022

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The relevance of the polymorphic form, particle size, and processing of mannitol for the mechanical properties of solid oral dosage forms was examined. Thus, particle and powder properties of spray granulated β D-mannitol, β D-mannitol, and δ D-mannitol were assessed in this study with regards to their manufacturability. D-mannitol is a commonly used excipient in pharmaceutical formulations, especially in oral solid dosage forms, and can be crystallized as three polymorphic forms, of which β is the thermodynamically most stable form and δ is a kinetically stabilized polymorph. A systematic analysis of the powders as starting materials and their respective roller compacted granules is presented to elucidate the multidimensional effects of powder and granules characteristics such as polymorphic form, particle size, and preprocessing on the resulting tablets’ mechanical properties. In direct compression and after roller compaction, δ polymorph displayed superior tableting properties over β mannitol, but was outperformed by spray granulated β mannitol. This could be primarily correlated to the higher specific surface area, leading to higher bonding area and more interparticle bonds within the tablet. Hence, it was shown that surface characteristics and preprocessing can prevail over the impact of polymorphism on manufacturability for oral solid dosage forms.

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Section: Resultsmentioning

confidence: 99%