Investigation on the antimicrobial activities of gingers (<i>Etlingera coccinea</i>
 (Blume) S.Sakai &amp; Nagam and <i>Etlingera sessilanthera</i>
 R.M.Sm.) endemic to Borneo

Daniel‐Jambun, Delhousie; Dwiyanto, Jacky; Lim, Yau Yan; Tan, Joash Ban Lee; Muhamad, Azira; Yap, Sau Wai; Lee, Sui Mae

doi:10.1111/jam.13536

Cited by 15 publications

(12 citation statements)

References 35 publications

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“…No antimicrobial activity was observed for all plant parts of E. pubescens against the Gram-negative bacterial strains tested. Similar findings were also reported by Chan et al (2007) and Daniel-Jambun et al (2017) in which extracts from other Etlingera plants only inhibited the growth of Gram-positive bacteria. Though only the Gram-positive bacteria were affected, the extract inhibited several clinically relevant bacterial strains such as methicillin-resistant S. aureus ATCC 43300, thus suggesting its potential to be mined for antimicrobial compounds.…”

Section: Discussionsupporting

confidence: 89%

“…() and Daniel‐Jambun et al . () in which extracts from other Etlingera plants only inhibited the growth of Gram‐positive bacteria. Though only the Gram‐positive bacteria were affected, the extract inhibited several clinically relevant bacterial strains such as methicillin‐resistant S. aureus ATCC 43300, thus suggesting its potential to be mined for antimicrobial compounds.…”

Section: Discussionmentioning

confidence: 99%

“…In our previous work, we showed that Etlingera coccinea and Etlingera sessilanthera also have excellent antimicrobial properties (MIC values determined ranged from 0·016 to 1 mg ml −1 ), with trans ‐2‐dodecenal and 8(17),12‐labdadiene‐15,16‐dial being identified as the major antimicrobials in each plant species, respectively (Daniel‐Jambun et al . ). Etlingera plants hold an exciting potential to be mined for antimicrobial compounds.…”

Section: Introductionmentioning

confidence: 97%

“…Moreover, E. elatior extracts could inhibit bacterial growth, with minimum inhibitory concentration (MIC) values determined as low as 0Á03 mg ml À1 against Staphylococcus aureus (Ghasemzadeh et al 2015). In our previous work, we showed that Etlingera coccinea and Etlingera sessilanthera also have excellent antimicrobial properties (MIC values determined ranged from 0Á016 to 1 mg ml À1 ), with trans-2dodecenal and 8(17),12-labdadiene-15,16-dial being identified as the major antimicrobials in each plant species, respectively (Daniel-Jambun et al 2017). Etlingera plants hold an exciting potential to be mined for antimicrobial compounds.…”

Section: Introductionmentioning

confidence: 99%

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Bactericidal and cytotoxic activity of a diarylheptanoid (etlingerin) isolated from a ginger ( Etlingera pubescens ) endemic to Borneo

et al. 2019

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Aims The aim of this study was to investigate the antimicrobial activities of Etlingera pubescens, and to isolate and identify the antimicrobial compound. Methods and Results The crude extracts of E. pubescens were obtained through methanol extraction, and evaluated for antimicrobial activities. From this extract, 1,7‐bis(3,4‐dihydroxyphenyl)heptan‐3‐yl acetate (etlingerin) was isolated. When compared to curcumin (a compound with a similar chemical structure), etlingerin showed twofold lower minimum inhibitory concentration values while also being bactericidal. Through time kill assay, etlingerin showed rapid killing effects (as fast as 60 min) against the Gram‐positive bacteria (Staphylococcus aureus ATCC 43300 and Bacillus subtilis ATCC 8188). Further assessment revealed that etlingerin caused leakage of intracellular materials, therefore suggesting alteration in membrane permeability as its antimicrobial mechanism. Cytotoxicity study demonstrated that etlingerin exhibited approximately 5‐ to 12‐fold higher IC50 values against several cell lines, as compared to curcumin. Conclusions Etlingerin isolated from E. pubescens showed better antibacterial and cytotoxic activities when compared to curcumin. Etlingerin could be safe for human use, though further cytotoxicity study using animal models is needed. Significance and Impact of the Study Etlingerin has a potential to be used in treating bacterial infections due to its good antimicrobial activity, while having potentially low cytotoxicity.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Bactericidal and cytotoxic activity of a diarylheptanoid (etlingerin) isolated from a ginger ( Etlingera pubescens ) endemic to Borneo

et al. 2019

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“…The total run time was 23 min. The column used was C180, flow rate was 1 mL/min, DAD detector was set at 254 nm, and electrospray ionization was used in the positive mode [26] .…”

Section: Liquid Chromatography-mass Spectrometry (Lc-ms) Analysismentioning

confidence: 99%

Molecular Characterization of a Fungus Producing Membrane Active Metabolite and Analysis of the Produced Secondary Metabolite

Azerang

Khalaj

Kobarfard

et al. 2019

ibj

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Background: The majority of studies on soil Aspergillus concern the isolation and characterization of the antimicrobial compounds produced by this organism. Our previous studies indicated an isolated Aspergillus strain soil to be of interest, and this subject is further investigated here. Method: Soil samples of various locations in Iran were collected. Extract from Aspergillus sp. culture was obtained using ethyl acetate fractionation. Antimicrobial activity testing was performed using broth microdilution assay against Escherichia coli, Candida albicans, and Staphylococcus aureus microorganisms. One metabolite PA3-d10 was isolated from these active extracts and identified using thin layer chromatography, preparative thin-layer chromatography, HPLC, 1 HNMR (proton nuclear magnetic resonance), 2D NMR, and LC-MS (liquid chromatography-mass spectrometry). Results: According to morphological and biochemical properties as well as ITS rDNA sequencing, we identified an isolate of Aspergillus flavus. The ethyl acetate fraction of the fermentation medium containing membrane active metabolites showed antimicrobial effects against different bacterial and yeast indicator strains. One metabolite from these active extracts was finally identified. Conclusion: Membrane active fraction produced by Aspergillus strain in this research demonstrated antimicrobial activities against bacteria and yeast strains. Therefore, this metabolite can be considered as a potential antimicrobial membrane active agent.

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Etlingera coccinea (Blume) S. Sakai & Nagam. Zingiberaceae

Devanathan¹,

Mustaqim²

2020

Ethnobotany of Mountain Regions

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Investigation on the antimicrobial activities of gingers (Etlingera coccinea (Blume) S.Sakai & Nagam and Etlingera sessilanthera R.M.Sm.) endemic to Borneo

Cited by 15 publications

References 35 publications

Bactericidal and cytotoxic activity of a diarylheptanoid (etlingerin) isolated from a ginger ( Etlingera pubescens ) endemic to Borneo

Bactericidal and cytotoxic activity of a diarylheptanoid (etlingerin) isolated from a ginger ( Etlingera pubescens ) endemic to Borneo

Molecular Characterization of a Fungus Producing Membrane Active Metabolite and Analysis of the Produced Secondary Metabolite

Etlingera coccinea (Blume) S. Sakai & Nagam. Zingiberaceae

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