Investigation on replication of microfluidic channels by hot embossing

Çoğun, Ferah; Yıldırım, Ender; Arikan, M. A. Sahir

doi:10.1080/10426914.2017.1317795

Cited by 28 publications

(12 citation statements)

References 19 publications

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“…Moreover, the force for demoulding also requires optimization; once the hardened material is removed from the mould, care should be taken to prevent distortion of the newly formed structure [ 131 ]. A study by Cogun et al (2017) investigated the hot embossing technique on poly(methyl methacrylate) (PMMA) microfluidic channels [ 132 ]. The authors developed microchannels with varying widths and depths to observe differences in the replication rates and symmetrical manifestations.…”

Section: Fabrication Techniques For Microfluidic Systemsmentioning

confidence: 99%

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Microfluidic Organ-on-A-chip: A Guide to Biomaterial Choice and Fabrication

Cao

Zhang

Chen

et al. 2023

IJMS

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Organ-on-a-chip (OoAC) devices are miniaturized, functional, in vitro constructs that aim to recapitulate the in vivo physiology of an organ using different cell types and extracellular matrix, while maintaining the chemical and mechanical properties of the surrounding microenvironments. From an end-point perspective, the success of a microfluidic OoAC relies mainly on the type of biomaterial and the fabrication strategy employed. Certain biomaterials, such as PDMS (polydimethylsiloxane), are preferred over others due to their ease of fabrication and proven success in modelling complex organ systems. However, the inherent nature of human microtissues to respond differently to surrounding stimulations has led to the combination of biomaterials ranging from simple PDMS chips to 3D-printed polymers coated with natural and synthetic materials, including hydrogels. In addition, recent advances in 3D printing and bioprinting techniques have led to the powerful combination of utilizing these materials to develop microfluidic OoAC devices. In this narrative review, we evaluate the different materials used to fabricate microfluidic OoAC devices while outlining their pros and cons in different organ systems. A note on combining the advances made in additive manufacturing (AM) techniques for the microfabrication of these complex systems is also discussed.

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Section: Fabrication Techniques For Microfluidic Systemsmentioning

confidence: 99%

“…These results demonstrated that the flow property and the heated temperature significantly influenced the skewness of the substrate. The optimal parameter for this technique was reported at 115 °C, 10 kN, and 8 min for a microchannel of 56 um width and 120 um depth [ 132 ].…”

Section: Fabrication Techniques For Microfluidic Systemsmentioning

confidence: 99%

Microfluidic Organ-on-A-chip: A Guide to Biomaterial Choice and Fabrication

Cao

Zhang

Chen

et al. 2023

IJMS

View full text Add to dashboard Cite

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“…Moreover, micromilling of PMMA by using end-mills with diameter as low as 20 µm have also been demonstrated [19]. On the other hand, the process can also be utilized to fabricate moulds for embossing [20] or PDMS moulding. The principles of operation of micromilling are essentially the same as for the conventional vertical milling process.…”

Section: Micromillingmentioning

confidence: 99%

Low-Cost Microfabrication Tool Box

et al. 2020

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Microsystems are key enabling technologies, with applications found in almost every industrial field, including in vitro diagnostic, energy harvesting, automotive, telecommunication, drug screening, etc. Microsystems, such as microsensors and actuators, are typically made up of components below 1000 microns in size that can be manufactured at low unit cost through mass-production. Yet, their development for commercial or educational purposes has typically been limited to specialized laboratories in upper-income countries due to the initial investment costs associated with the microfabrication equipment and processes. However, recent technological advances have enabled the development of low-cost microfabrication tools. In this paper, we describe a range of low-cost approaches and equipment (below £1000), developed or adapted and implemented in our laboratories. We describe processes including photolithography, micromilling, 3D printing, xurography and screen-printing used for the microfabrication of structural and functional materials. The processes that can be used to shape a range of materials with sub-millimetre feature sizes are demonstrated here in the context of lab-on-chips, but they can be adapted for other applications. We anticipate that this paper, which will enable researchers to build a low-cost microfabrication toolbox in a wide range of settings, will spark a new interest in microsystems.

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“…The pressure force for embossing which is designed depends on the thickness of the copper film and substrate. There, the copper film is cut to form a positive bond to locally melted plastic close to the surface of the blank [ 39 , 40 , 41 , 42 , 43 , 44 , 45 ].…”

Section: Single-shot Injection Moldingmentioning

confidence: 99%

3D-MID Technology for Surface Modification of Polymer-Based Composites: A Comprehensive Review

et al. 2020

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The three-dimensional molded interconnected device (3D-MID) has received considerable attention because of the growing demand for greater functionality and miniaturization of electronic parts. Polymer based composite are the primary choice to be used as substrate. These materials enable flexibility in production from macro to micro-MID products, high fracture toughness when subjected to mechanical loading, and they are lightweight. This survey proposes a detailed review of different types of 3D-MID modules, also presents the requirement criteria for manufacture a polymer substrate and the main surface modification techniques used to enhance the polymer substrate. The findings presented here allow to fundamentally understand the concept of 3D-MID, which can be used to manufacture a novel polymer composite substrate.

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Investigation on replication of microfluidic channels by hot embossing

Cited by 28 publications

References 19 publications

Microfluidic Organ-on-A-chip: A Guide to Biomaterial Choice and Fabrication

Microfluidic Organ-on-A-chip: A Guide to Biomaterial Choice and Fabrication

Low-Cost Microfabrication Tool Box

3D-MID Technology for Surface Modification of Polymer-Based Composites: A Comprehensive Review

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