Investigation on physicochemical properties of plasma-activated water for the application of medical device sterilization

Abuzairi, Tomy; Ramadhanty, Savira; Puspohadiningrum, Dini Fithriaty; Ratnasari, Anita; Poespawati, Nji Raden; Purnamaningsih, Retno Wigajatri

doi:10.1063/1.5023987

Cited by 22 publications

(18 citation statements)

References 24 publications

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“…This more enhanced production of RONS in a biopolymer solution than in water or Ringer’s saline was also observed in our previous work with alginate solutions . This difference can be explained by the pH buffering effect of the gelatin solution; while pH decreased with plasma treatment time in Ringer’s saline or water (Figure d), as also reported in other works, − the pH remained unaltered in buffered saline such as PBS, in alginate or here in gelatin solution. In general, different reactions are fostered in acidic media: NO 2 – reacts with H 2 O 2 to form peroxynitrites, and nitrous acidone of the major sources of nitritesdecomposes in acidic media, ,,, among other reactions.…”

Section: Discussionsupporting

confidence: 88%

Enhanced Generation of Reactive Species by Cold Plasma in Gelatin Solutions for Selective Cancer Cell Death

Labay

Roldán

Tampieri

et al. 2020

ACS Appl. Mater. Interfaces

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Atmospheric pressure plasma jets generate reactive oxygen and nitrogen species (RONS) in liquids and biological media, which find application in the new area of plasma medicine. These plasma-treated liquids demonstrated recently to possess selective properties on killing cancer cells and attract attention towards new plasma-based cancer therapies. These allow for local delivery by injection in the tumor but can be quickly washed away by body fluids. By confining these RONS in a suitable biocompatible delivery system, great perspectives can be opened in the design of novel biomaterials aimed for cancer therapies. Gelatin solutions are evaluated here to store RONS generated by atmospheric pressure plasma jets, and their release properties are evaluated. The concentration of RONS was studied in 2% gelatin as a function of different plasma parameters (treatment time, nozzle distance and gas flow) with two different plasma jets. Much higher production of reactive species (H 2 O 2 and NO 2-) was revealed in the polymer solution than in water after plasma treatment. The amount of RONS generated in gelatin is greatly improved with respect to water, with concentrations of H 2 O 2 and NO 2between 2 and 12 times higher for the longest plasma treatments. Plasma-treated gelatin exhibited the release of these RONS to a liquid media, which induced an effective killing of bone cancer cells. Indeed, in vitro studies on Sarcoma Osteogenic (SaOS-2) cell line exposed to plasma-treated gelatin lead to timedependent increasing cytotoxicity with the longer plasma treatment time of gelatin. While SaOS-2 cell viability decreased down to 12%-23% after 72 hours for cells exposed to 3-min treated gelatin, viability of healthy cells (hMSC) was preserved (around 90%), establishing the selectivity of the plasma-treated gelatin on cancer cells. This sets the basis for designing improved hydrogels with high capacity to deliver RONS locally to tumors.

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Section: Discussionsupporting

confidence: 88%

Enhanced Generation of Reactive Species by Cold Plasma in Gelatin Solutions for Selective Cancer Cell Death

Labay

Roldán

Tampieri

et al. 2020

ACS Appl. Mater. Interfaces

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“…Plasma-activated Water (PAW) is highly concentrated with chemically reactive oxygen and nitrogen species (RONS). Plasma-activated water is generated by treating water with plasma devices such as the atmospheric pressure plasma ( Abuzairi et al, 2018 ), plasma jet ( Adhikari et al, 2019 ), DBD ( Judée et al, 2018 ), spark or glow discharges ( Lu et al, 2017 ) and corona discharges ( Lukes et al, 2008 ). The composition and concentration of these species in water depend on the type of gas, applied voltage, treatment time and whether the plasma source is discharged directly into water or above water's surface ( Oh et al, 2016 ).…”

Section: Plasma-activated Water (Paw)mentioning

confidence: 99%

Cold plasma technologies: Their effect on starch properties and industrial scale-up for starch modification

Okyere

Rajendran

Annor

2022

Current Research in Food Science

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“…NO X in water has stable anions which are involved in signaling during the biophysiological processes of the plant. For example, NO − 2 is advantageous for inducing seed germination, as it is involved in the regulation of dormancy-linked endogenous hormones of seeds [19,20,69]. An abundance of nitrogen in plants can be observed as a deep green color of the leaves, increased protein content, and increased grain plumpness [2].…”

Section: Discussionmentioning

confidence: 99%

Low-Temperature Plasma-Assisted Nitrogen Fixation for Corn Plant Growth and Development

Lamichhane

Veerana

Lim

et al. 2021

IJMS

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Nitrogen fixation is crucial for plants as it is utilized for the biosynthesis of almost all biomolecules. Most of our atmosphere consists of nitrogen, but plants cannot straightforwardly assimilate this from the air, and natural nitrogen fixation is inadequate to meet the extreme necessities of global nutrition. In this study, nitrogen fixation in water was achieved by an AC-driven non-thermal atmospheric pressure nitrogen plasma jet. In addition, Mg, Al, or Zn was immersed in the water, which neutralized the plasma-treated water and increased the rate of nitrogen reduction to ammonia due to the additional hydrogen generated by the reaction between the plasma-generated acid and metal. The effect of the plasma-activated water, with and without metal ions, on germination and growth in corn plants (Zea Mays) was investigated. The germination rate was found to be higher with plasma-treated water and more efficient in the presence of metal ions. Stem lengths and germination rates were significantly increased with respect to those produced by DI water irrigation. The plants responded to the abundance of nitrogen by producing intensely green leaves because of their increased chlorophyll and protein contents. Based on this report, non-thermal plasma reactors could be used to substantially enhance seed germination and seedling growth.

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Investigation on physicochemical properties of plasma-activated water for the application of medical device sterilization

Cited by 22 publications

References 24 publications

Enhanced Generation of Reactive Species by Cold Plasma in Gelatin Solutions for Selective Cancer Cell Death

Enhanced Generation of Reactive Species by Cold Plasma in Gelatin Solutions for Selective Cancer Cell Death

Cold plasma technologies: Their effect on starch properties and industrial scale-up for starch modification

Low-Temperature Plasma-Assisted Nitrogen Fixation for Corn Plant Growth and Development

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