Investigation on modes of toxic action to rats based on aliphatic and aromatic compounds and comparison with fish toxicity based on exposure routes

He, Jia; Li, Jin J.; Wen, Yuezhong; Tai, Hong W.; Yu, Yang; Qin, Wei C.; Su, Li Ming; Zhao, Yuan H.

doi:10.1016/j.chemosphere.2015.01.028

Cited by 19 publications

(4 citation statements)

References 28 publications

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“…An increasing number of emerging PFASs, with similar persistence and/or bioaccumulation potential to legacy PFASs, , have recently been reported to be ubiquitous in environmental and biota samples. − In the present study, OBS, a little studied PFAS, was observed with high DF and at higher concentrations compared to PFOS in surface water from an oilfield area, implying an exposure risk to the local environment and its inhabitants. Although the environmental behavior and toxicological effects are currently not clearly known, some compounds containing benzene in their structure have been deemed to be more toxic than their aliphatic counterparts. , Through our preliminary toxicity assessment, OBS was classified in Category III according the GHS definition, similar to PFOS. We also preliminarily evaluated its degradation potential via model estimation and found that the estimated degradation time of OBS was approximately 400 days indicating that OBS is a highly recalcitrant pollutant.…”

Section: Discussionmentioning

confidence: 99%

“…Although the environmental behavior and toxicological effects are currently not clearly known, some compounds containing benzene in their structure have been deemed to be more toxic than their aliphatic counterparts. 59,60 Through our preliminary toxicity assessment, OBS was classified in Category III according the GHS definition, similar to PFOS. We also preliminarily evaluated its degradation potential via model estimation and found that the estimated degradation time of OBS was approximately 400 days indicating that OBS is a highly recalcitrant pollutant.…”

Section: Environmental Science and Technologymentioning

confidence: 99%

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Discovery of a Novel Polyfluoroalkyl Benzenesulfonic Acid around Oilfields in Northern China

Shi

et al. 2017

Environ. Sci. Technol.

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The existence of more than 3000 per- and polyfluoroalkyl substances (PFASs) on the global market has prompted the identification and hazard characterization of hitherto unknown PFASs. In the present study, a novel PFAS, sodium p-perfluorous nonenoxybenzenesulfonate (OBS), was identified using Orbitrap MS/MS in water samples around a suspected application area, Daqing Oilfield, China. The peak OBS concentration was 3.2 × 10 ng/L in a sample taken near the oil well with the longest production history in Daqing. The concentrations of OBS and contribution to the sum of PFASs in surface waters displayed considerable variation among the three sampling areas (mean levels at 6.9, 50, and 5.6 × 10 ng/L with mean percentages at 9.8%, 45%, and 69% in the background, new and old oilfield areas respectively) confirming that the density of oil wells and the oil production history are important factors influencing OBS contamination in the studied areas. A preliminary assessment of acute toxicity and environmental fate indicates that OBS exhibits similar toxicity and environmental persistence to perfluorooctanesulfonic acid (PFOS). The widespread occurrence of OBS, in conjunction with its potential hazard properties, underscores the need to further study on the bioaccumulation and potential for human exposure.

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Section: Discussionmentioning

confidence: 99%

Section: Environmental Science and Technologymentioning

confidence: 99%

Discovery of a Novel Polyfluoroalkyl Benzenesulfonic Acid around Oilfields in Northern China

Shi

et al. 2017

Environ. Sci. Technol.

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“…The test results show that cyanidin belongs to class 5, which is a group of compounds that cannot be classified based on the parameters of the Verhaar scheme so that further testing is required [14] . [26] . Class 1 compounds are not 56 DOI : https://doi.org/10.24843/JPSA.2023.v05.i01.p07 reactive and do not interact specifically with receptors on organisms [14] .…”

Section: Discussionmentioning

confidence: 99%

In Silico Toxicity of Anthocyanin Compounds (Cyanidin and Peonidin)

Susanti

Wisesa

Juwianti

2023

JPSA

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Backgrounds: Cyanidin and peonidin, anthocyanin compounds, have many in silico, in vitro, and in vivo activities, including antioxidant, anticancer, antihyperlipidemic, and antidiabetic. Toxicity testing is carried out to determine the potential hazard that may be produced by the test compound. Objective: This study was aimed to determine the in silico toxicity of anthocyanins (cyanidin and peonidin) using Toxtree v3.1.0 software. Methods: In silico toxicity testing was carried out using 2D structures of cyanidin and peonidin with Cramer rules, Verhaar scheme, Benigni/Bossa rulebase, Kroes TTC decision tree, Eye Irritation/Corrosion and Skin Irritation/Corrosion parameters. Data analysis on the results of the tested toxicity parameters was carried out descriptively. Results: The results showed that the two compounds have the same category for the toxicity parameters of Cramer Rules (class III), Kroes TTC Decision Tree (substance would not be expected to be safety concern), Benigni/Bossa Rulebase (Negatif for genotoxic and nongenotoxic carcinogenicity), Eye Irritation/Corrosion and Skin Irritation/Corrosion (not irritating or corrosive). Different results are shown in the parameters of the Verhaar Scheme, where cyanidin is included in class 5 (cannot be classified based on this parameter), while peonidin is included in class 1 (narcosis or basic toxicity). Conclusion: Based on in silico toxicity, cyanidin and peonidin have a chemical structure that has the potential for toxicity, but these compounds are neither potentially genotoxic nor non-genotoxic carcinogenicity, and are not potentially toxic to the skin and eyes. The toxicity mechanism of cyanidin cannot be classified based on the test parameters while peonidin is narcosis or basic toxicity.Keywords: Anthocyanin; Cyanidin; Peonidin; Toxicity; In Silico

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“…Aromatic compounds are among the main pollutants with considerable hazards to living systems. Polycyclic aromatic hydrocarbons (PAHs) are lipophilic highly soluble compounds in organic solvents including fused aromatic rings with various toxicities produced mainly via incomplete combustion and pyrolysis of materials containing carbon and hydrogen, such as coal, oil, wood and petroleum products [25, 26]. Many reports confirmed that aromatic compounds especially PAHs are environmentally persistent poisons with carcinogenic, immune suppressant and mutagenic effects.…”

Section: Introductionmentioning

confidence: 99%

Biosynthesis of reusable and recyclable CuO@Magnetite@Hen Bone NCs and its antioxidant and antibacterial activities: a highly stable magnetically nanocatalyst for excellent reduction of organic dyes and adsorption of polycyclic aromatic hydrocarbons

Sajadi

Kolo

Hamad

et al. 2018

IET nanobiotechnol.

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For the first time, through a fast, eco-friendly and economic method, the aqueous extract of the leaf of Euphorbia corollate was used to the green synthesis of the highly stable CuO@Magnetite@Hen Bone nanocomposites (NCs) as a potent antioxidant and antibacterial agent against Pseudomonas aureus, Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae pathogenic bacteria. The biosynthesised NCs were identified using the scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy, elemental mapping, X-ray diffraction (XRD), Fourier transforms infrared spectroscopy and UV-vis analytical techniques. Also, the radical scavenging activity using (2,2-diphenyl-1-picrylhydrazyl) method was used to evaluate the antioxidant activity of the NCs. The stability of nanocatalyst was monitored using the XRD and SEM analyses after 30 days from its synthesis. Furthermore, its excellent catalytic activity, recycling stability, and high substrate applicability were demonstrated to the adsorption of the polycyclic aromatic hydrocarbons of the light crude oil from Shiwashok oil fields and destruction of methylene blue and methyl orange as harmful organic dyes at ambient temperature using UV-vis spectroscopy. Moreover, the green CuO@Magnetite@Hen Bone NCs were recovered and reused several times without considerable loss of its catalytic activity.

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Investigation on modes of toxic action to rats based on aliphatic and aromatic compounds and comparison with fish toxicity based on exposure routes

Cited by 19 publications

References 28 publications

Discovery of a Novel Polyfluoroalkyl Benzenesulfonic Acid around Oilfields in Northern China

Discovery of a Novel Polyfluoroalkyl Benzenesulfonic Acid around Oilfields in Northern China

In Silico Toxicity of Anthocyanin Compounds (Cyanidin and Peonidin)

Biosynthesis of reusable and recyclable CuO@Magnetite@Hen Bone NCs and its antioxidant and antibacterial activities: a highly stable magnetically nanocatalyst for excellent reduction of organic dyes and adsorption of polycyclic aromatic hydrocarbons

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