Investigation on leukocyte profile of periparturient cows with or without postpartum reproductive disease

Islam, Rafiqul; Kumar, Harendra; Krishnan, Binsila B.

doi:10.1016/s2305-0500(14)60003-8

Cited by 13 publications

(7 citation statements)

References 34 publications

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“…These differences might indicate the altered immune status of the cows with metritis, which requires further investigations. The WBC, Gran and Mon continued to increase in cows with metritis at 7 and 30 d. Such changes in cows have been reported in a few studies [2, 7, 23, 24], indicating a potential persistent peripheral inflammatory response in the cows with uterine infection.…”

Section: Discussionsupporting

confidence: 71%

Changes in the blood routine, biochemical indexes and the pro-inflammatory cytokine expressions of peripheral leukocytes in postpartum dairy cows with metritis

et al. 2019

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Background The aim of the present study was to clarify the changes in complete blood count, blood biochemistry, and the gene expressions of pro-inflammatory cytokines of peripheral white blood cells in postpartum dairy cows with metritis. Results The cows were assigned to the control group ( n = 28) or the metritis group ( n = 28), retrospectively. Blood samples were taken 7 days before the estimated parturition (− 7 d), on the day of parturition (0 d), and 7 and 30 d after parturition. There was no difference in blood indexes between the control group and the metritis group at − 7 d. The WBC, granulocytes and monocytes were generally higher at 7 and 30 d in the metritis group than the control. In comparison with the controls, all liver function parameters and triglyceride levels at 0, 7 and 30 d, and the creatinine level at 7 and 30 d were higher in cows with metritis. The concentrations of Ca and P at 0, 7 and 30 d, and of glucose at 0 d were lower for cows in the metritis group compared with cows in the control group. Among these parameters, the WBC at 30 d, the aspartate aminotransferase activity (AST) at 7 d exceeded normal ranges (WBC: 5.0 ~ 16.0 × 10 9 /L; AST: 42.5 ~ 98 U/L), whereas the concentrations of glucose and Ca from 0 to 30 d were below normal ranges (glucose: 2.5 ~ 4.5 mmol/L; Ca: 2.2 ~ 2.5 mmol/L) in the metritis group. The gene expressions of pro-inflammatory cytokines in the metritis group were higher than those in the control group, including the IL-1α at 7d, the IL-1β at − 7, 0 and 7 d, the IL-6 at − 7, 0, 7 and 30 d, the IL-8 at 0, 7 and 30 d, and the TNF-α at 7 and 30 d. Conclusion The cows with metritis experienced systemic inflammation for 4 weeks after calving, the impaired hepatic function, and the altered metabolic status with increased triglyceride level and decreased concentrations of glucose, Ca and P.

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Section: Discussionsupporting

confidence: 71%

Changes in the blood routine, biochemical indexes and the pro-inflammatory cytokine expressions of peripheral leukocytes in postpartum dairy cows with metritis

et al. 2019

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“…The leukocyte and neutrophil population diminished more in cows suffering clinical endometritis compared to healthy bovine animals. Results of this study were consistent with the reported data on specialized dairy cattle (Islam et al, 2014;Bromfield et al, 2018) from which not only a decline in the population of neutrophils has been informed but also in their immunological capacity and still, a greater loss of such in the cows having metritis (McDougall et al, 2017;Kimura et al, 2014).…”

Section: Discussionsupporting

confidence: 91%

“…On completion, the first three drops were discarded, and the fourth drop inserted into the Neubauer chamber, which sat for a minute until the solution and cells settled. Leukocyte counting took place and the number of found cells in all four quadrants were added, for subsequently multiplying by 50 (factor) to obtain the number of leukocyte cells per cubic millimeter of blood (Islam et al, 2014).…”

Section: Methodsmentioning

confidence: 99%

Indicators of immunosuppression peripartum in dual purpose cows in the tropics affected health, productive and reproductive parameters

et al. 2021

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The objective of the study was to identify immunosuppression peripartum indicators in dual purpose cows in the tropics and determine their effects on productive and reproductive parameters. The indicators used were: changes in leukocyte and neutrophils population, concentrations of energy metabolites (βhydroxybutyrate and glucose) and body condition scores (BCS). Blood sampling and BCS (scale 1 -5) were taken weekly during the peripartum. Uterine health was assessed (3 weeks postpartum) by ultrasonography and using a vaginal score (0-3) described by Sheldon et al. (2006). Cows (n=30) were classified as healthy or clinical endometritis (CE). CE prevalence was as high as 29.6%. Leukocyte and neutrophils populations diminished while in the peripartum and were lower (P<0.05) in cows suffering CE. Healthy cows had higher (P<0.05) daily milk production than those with CE (18.84±0.63 vs 14.76±0.84 kg). CE cows had lower (P<0.05) reproductive performance compared with healthy cows (open days: 244.40 ± 35.00 vs 178.00 ± 23.33 and services by conception 3.33 ± 0.51 vs 1.83 ± 0.34). BCS similarly (P>0.05) decreased following parturition in both groups. Concentrations of energy metabolites during peripartum fluctuated in a similar (P>0.05) manner in healthy and CE cows. In summary, dual purpose cows in tropical conditions, presented peripartum immunosuppression indicators, characterized by a decline in the leukocyte population, mainly neutrophils, as well as decreased glucose concentrations and BCS postpartum. In addition to it, there was a rise in the β-hydroxybutyrate concentrations and cows presenting CE had a negative effect in the productive and reproductive parameters.

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“…As doenças reprodutivas no pós-parto incluem distocia (LAGO et al, 2001), endometrite (MATEUS et al, 2002;KASIMANICKAM et al, 2004;HEIDARPOUR et al, 2014;ISLAM et al, 2014), cetose (MARUTSOVA et al, 2015), retenção de placenta (ISLAM et al, 2014;SAUT et al, 2014;MORETTI et al, 2016), involução uterina tardia (ISLAM et al, 2014) mastite, hipocalcemia (FAGLIARI e ROCHA et al, 2011) e outras.…”

Section: Hemogramaunclassified

“…A avaliação completa Os neutrófilos migram para o tecido danificado após estímulo para realizar a fagocitose de corpos estranhos e bactérias (MORRIS, 2002). O neutrófilo é a primeira célula a chegar ao local da infecção e proteger o organismo de várias doenças infecciosas através da fagocitose (ISLAM et al, 2014). A neutrofilia é causada principalmente pela presença de inflamação, podendo ocorrer em resposta a processos infecciosos, lesão tecidual, doenças neoplásicas e condições não inflamatórias.…”

Section: Hemogramaunclassified

Parâmetros hematológicos e perfil sérico dos hormônios tireoidianos em vacas mestiças no pós-parto

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Investigation on leukocyte profile of periparturient cows with or without postpartum reproductive disease

Cited by 13 publications

References 34 publications

Changes in the blood routine, biochemical indexes and the pro-inflammatory cytokine expressions of peripheral leukocytes in postpartum dairy cows with metritis

Changes in the blood routine, biochemical indexes and the pro-inflammatory cytokine expressions of peripheral leukocytes in postpartum dairy cows with metritis

Indicators of immunosuppression peripartum in dual purpose cows in the tropics affected health, productive and reproductive parameters

Parâmetros hematológicos e perfil sérico dos hormônios tireoidianos em vacas mestiças no pós-parto

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