Investigation on Atypical Pathogens related with Community Acquired Pneumonia and the Factors Associated with Mycoplasma Pneumoniae Infection in Jiangsu, China

Wang, Zhiguo; Ji, Yun; Zhang, Jing; Su, Kelei; Fan, Heng; Yang, Wei; Zhang, Yeqing; Yao, Xiao-Ming

doi:10.7754/clin.lab.2019.191036

Cited by 3 publications

(2 citation statements)

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“…It manifests primarily in infants and young children, people older than 65 years and people with underlying health problems [2]. A variety of organisms, such as bacteria, viruses and fungi, can cause pneumonia and simultaneously increase the risk of hospitalization [3,4]. Pneumonia is a heterogeneous disease categorized into two subclasses (viral and bacterial).…”

Section: Introductionmentioning

confidence: 99%

Efficacy of corticosteroids as an adjunctive therapy in the treatment of community-acquired pneumonia: a systematic review and meta-analysis

Mukanhaire

Fan

et al. 2023

Acta Materia Medica

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The objective of this study was to systematically evaluate the clinical efficacy of the complementary use of corticosteroids in the treatment of community-acquired pneumonia (CAP). We searched all relevant documents in five scientific databases from inception to June 2022 to collect clinical trials (randomized controlled trials and controlled trials) reporting on the adjunctive use of corticosteroids in CAP treatment. The primary outcome was mortality, and secondary outcomes included the time to clinical stability, therapeutic efficacy, duration of antibiotic treatment and length of hospital/ICU stay. Therapeutic efficacy was defined as the rate of achieving clinical recovery with no fever, improvement or disappearance of cough. Clinical stability was defined by improvements in laboratory values. Two researchers independently screened the literature according to the inclusion and exclusion criteria, extracted data and evaluated the quality of literature. Statistical analysis and meta-analysis of intervention measures and indicators were performed with IBM SPSS and RevMan 5.4 software. Nine randomized controlled trials comprising 2673 participants with CAP (1335 in the corticosteroid group and 1338 in the control group) were identified and included in this study. The mean cumulative corticosteroid dose and treatment duration were 298.00±287.140 mg and 5.22±1.787 days, respectively. Corticosteroid treatment was not associated with a significant decrease in mortality (RR; 95% CI, 0.96 [0.67–1.38], P=0.83). Because of the low number of included patients in our study, more studies with larger sample sizes and high-quality randomized, double-blind controlled trials are needed to confirm the results.

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Section: Introductionmentioning

confidence: 99%

Efficacy of corticosteroids as an adjunctive therapy in the treatment of community-acquired pneumonia: a systematic review and meta-analysis

Mukanhaire

Fan

et al. 2023

Acta Materia Medica

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“…It is most serious for infants and young children, people older than 65,and people with underlying health problems or weakened immune system [3].Pneumonia can be broadly categorized as community-acquired pneumonia, hospital acquired (nosocomial) pneumonia and ventilator associated [4]. Specific pathogens such as mycoplasma pneumoniae, streptococcus pneumoniae, respiratory syncytial virus and haemophilus influenza type b have been found to increase the risk of hospitalization [5].Risk factors for pneumonia in children include infancy, premature birth, incomplete immunization, maternal smoking or household tobacco smoke exposure, indoor air pollution, low birthweight, malnutrition, lack of exclusive breastfeeding and overcrowding [6,7].…”

Section: Introduction Rationalementioning

confidence: 99%

Recent advances in efficacy of corticosteroids as adjunct therapy for the treatment of community-acquired pneumonia in children: a systematic review and meta-analysis

Mukanhaire

Wang

Zong

et al. 2022

Preprint

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It has been recently shown that the adjunct use of corticosteroids in the treatment of community-acquired pneumonia shorten the time taken to reach clinical stability (time to clinical stability) in patients with community-acquired pneumonia (CAP). Considering the hyperglycemic effects of corticosteroids, there are concerns about the efficacy and safety of this therapy for children with CAP. Our objective is to evaluate the influence of recent advances in adjunct corticosteroid use and/or aerosolized antibiotic administration on admission to hospital with our main outcome being duration of fever and hospital stay, and additional outcomes as the time to clinical stability therapeutic efficacy, C-reactive protein and defervescence at 24, 48, and 72 hours after starting treatment in a well-defined cohort of children with community-acquired pneumonia. Therapeutic efficacy is defined as the rate of achieving clinical recovery with no fever, improvement or disappearance of cough, and improved or normal laboratory values. Five academic literature databases will be searched using Boolean keyword searches. Articles eligible for inclusion are those that present original research with the study topic as CAP, the study was designed as a randomized controlled trial (RCT) or clinical trial (CT) or an observational study with controls. The review will result in a narrative synthesis that summarizes the effectiveness of corticosteroid use in children.

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Analysis of mycoplasma pneumoniae infection among children with respiratory tract infections in hospital in Chengdu from 2014 to 2020

Zhang

Lai

et al. 2021

Transl Pediatr

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Investigation on Atypical Pathogens related with Community Acquired Pneumonia and the Factors Associated with Mycoplasma Pneumoniae Infection in Jiangsu, China

Cited by 3 publications

References 0 publications

Efficacy of corticosteroids as an adjunctive therapy in the treatment of community-acquired pneumonia: a systematic review and meta-analysis

Efficacy of corticosteroids as an adjunctive therapy in the treatment of community-acquired pneumonia: a systematic review and meta-analysis

Recent advances in efficacy of corticosteroids as adjunct therapy for the treatment of community-acquired pneumonia in children: a systematic review and meta-analysis

Analysis of mycoplasma pneumoniae infection among children with respiratory tract infections in hospital in Chengdu from 2014 to 2020

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