Investigation on a Test of Histocompatibility for Allogeneic Grafts

Matsukura, Makoto; Méry, A. M.; Amiel, J. L.; Mathé, G

doi:10.1097/00007890-196301010-00007

Cited by 28 publications

(8 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, bone marrow from six family donors were used for the transplant and in order to decide which donor may be used posttransplant to enhance GvL, the patient received skin grafts from all six donors. Histocompatibility tests at that time (9, 10) showed that the only skin graft, which was not rejected was the one which was closest genetically to the donor. This donor was subsequently used to give incremental doses of leukocyte treatment posttransplant and gave rise to GvL, but also GvHD.…”

Section: Introductionmentioning

confidence: 99%

Graft-versus-Leukemia Effect Following Hematopoietic Stem Cell Transplantation for Leukemia

et al. 2017

View full text Add to dashboard Cite

The success of hematopoietic stem cell transplantation (HSCT) lies with the ability of the engrafting immune system to remove residual leukemia cells via a graft-versus-leukemia effect (GvL), caused either spontaneously post-HSCT or via donor lymphocyte infusion. GvL effects can also be initiated by allogenic mismatched natural killer cells, antigen-specific T cells, and activated dendritic cells of leukemic origin. The history and further application of this GvL effect and the main mechanisms will be discussed and reviewed in this chapter.

show abstract

Section: Introductionmentioning

confidence: 99%

Graft-versus-Leukemia Effect Following Hematopoietic Stem Cell Transplantation for Leukemia

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Note the infiltration by lymphoid cells. formation of lymphocytes (Bach & Hirschhorn 1964) were not useful in this respect, but confirmed the usefulness of (1) the indirect histocompatibility test (so-called Third Man Test) which we proposed in 1962 and studied in the mouse, the rabbit and in man (Math6 et al 1961, Matsukura et al 1963,…”

Section: Subacute Syndromementioning

confidence: 61%

Immunogenetic and Immunological Problems of Allogeneic Haemopoietic Radio‐Chimaeras in Man

Mathé

Schwarzenberg

Amiel

et al. 1967

Scandinavian Journal of Haematology

Self Cite

View full text Add to dashboard Cite

Allogeneic bone marrow grafting is described in 21 human leukaemic subjects. Failure of the graft occurred in 6 cases and take in 15 cases. In the latter group, all 15 cases were complicated by the secondary syndrome, which was fatal in 11 cases and controlled in 4 cases. The immunogenetic and immunological factors determining the establishment and evolution of haematological radio‐chimaeras in man are discussed. The choice of donor in fundamental. Three tests are considered to be effective in donor selection, the indirect histocompatibility test (the so‐called third man test proposed by us), the leucocyte antigen test and the reaction of donor and recipient leucocytes in the dermis of an irradiated hamster. When marrow from several donors is transfused, the recipient spontaneously selects that genetically nearest. It seems likely there is more chance of finding a suitable donor among genetically related subjects than among those who are unrelated. The frequency of graft take seems slightly less in recipients who have previously received blood transfusions. Total bone marrow graft is associated with specific tolerance towards donor tissues. This is paralleled by the production in the chimaera of immunoglobulins produced by the graft. The secondary syndrome seems, as in animals, to be related essentially to the graft versus host reaction. It is convenient to distinguish between its various manifestations, on the one hand, those lesions which are readily controlled such as hepatitis or erythrodermia associated with infiltration and proliferation of immunologically competent cells from the graft, and on the other hand immune insufficiency with regard to micro organisms, especially viruses and Candida albicans. This latter group, the mechanism of which is complex, still eludes attempts at preventive and curative control. The use of multiple donors, the administration of cortisone during marrow transfusion and amethopterin and/or cyclophosphamide in the days following transfusions, all seem to have reduced the severity of the secondary syndrome, which however still cannot be satisfactory controlled. The graft reaction against the leukaemic cells is utilised as an antileukaemic treatment. In the 4 patients who escaped acute secondary syndrome survival has been notably longer, the longest lasted 20 months, when death from zoster encephalitis supervened. There were no clinical signs of leukaemia or histological evidence of this at autopsy.

show abstract

“…The advantage of a system of tissue typing based upon skin grafting is that the biologic activity of the test system is more closely related to the basic problem of transplantation. Preliminary work with a system of tissue typing in rabbits that parallels our technique has suggested that this might be a feasible procedure (16).…”

Section: Discussionmentioning

confidence: 99%