Investigation of zinc‑copper alloys as potential materials for craniomaxillofacial osteosynthesis implants

Li, Ping; Zhang, Wentai; Dai, Jingtao; Xepapadeas, Alexander Basileos; Schweizer, Ernst; Alexander, Dorothea; Scheideler, Lutz; Zhou, Chao; Zhang, Haijun; Wan, Guojiang; Geis‐Gerstorfer, Jürgen

doi:10.1016/j.msec.2019.109826

Cited by 78 publications

(64 citation statements)

References 63 publications

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“…By adding a vibration during the solidification of the cast rod, the dendritic peaks in the cast rod broke, resulting in the formation of more numerous and finer grains. Furthermore, as-cast pure Zn and its alloys exhibited dendritic structure with anisotropy, leading to relatively low strength [5]. For the Zn-Ag-Au-V alloy, the dendritic cast structure was successfully transformed into a globular structure through forming and heat treatment (solution annealing).…”

Section: Microstructure and Mechanical Propertiesmentioning

confidence: 99%

“…Obviously, "crystal-like" degradation products were observed at high The mechanical properties of the Zn-Ag-Au-V alloy are shown in Table 2. The strength of Zn-Ag-Au-V alloy was significantly enhanced compared to pure Zn [4,5]. After thermomechanical treatment and additional precipitation hardening, respectively, the mechanical properties were assessed.…”

Section: In Vitro Degradation Behaviormentioning

confidence: 99%

“…As shown in Figure 5, ICP-OES result shows that Zn 2+ was quickly released and increased the pH value in the initial period. With the Zn 2+ and OH − released, precipitations of Zn(OH) 2 and ZnO were formed on the surfaces, referring to Equations (4) and (5) [38,42]. Due to Zn(OH) 2 and ZnO layers formed, the release of Zn 2+ and the pH value trend became stable.…”

Section: In Vitro Degradation Behaviormentioning

confidence: 99%

“…In contrast, a relatively thin green fluorescence showed that the S. gordonii chains consisted of less viable and nonviable bacteria on the Zn-Ag-Au-V surfaces, indicating that initial S. gordonii colonization and biofilm formation were inhibited. Recently, Zn-based alloys have been demonstrated to be promising materials for craniomaxillofacial osteosynthesis implants [5,51]. An intraoral approach is the main access for maxillofacial surgery, and probably increases the risk of infection caused by oral bacteria.…”

Section: Antibacterial Evaluationmentioning

confidence: 99%

“…Absorbable (biodegradable) metals refer to metals degrading safely within the body. In that field, magnesium (Mg), iron (Fe), zinc (Zn), and their alloys have gained increasing interest as absorbable biocompatible materials potentially useable for vascular stents and osteosynthesis implants [1][2][3][4][5]. An appropriate degradation behavior is critical to maintain its mechanical integrity as well as the bioactivity of the implant during the whole tissue remodeling period.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of a Zn–2Ag–1.8Au–0.2V Alloy for Absorbable Biocompatible Materials

Li¹,

Schille²,

Schweizer³

et al. 2019

Materials

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Zinc (Zn) and Zn-based alloys have been proposed as a new generation of absorbable metals mainly owing to the moderate degradation behavior of zinc between magnesium and iron. Nonetheless, mechanical strength of pure Zn is relatively poor, making it insufficient for the majority of clinical applications. In this study, a novel Zn–2Ag–1.8Au–0.2V (wt.%) alloy (Zn–Ag–Au–V) was fabricated and investigated for use as a potential absorbable biocompatible material. Microstructural characterization indicated an effective grain-refining effect on the Zn alloy after a thermomechanical treatment. Compared to pure Zn, the Zn–Ag–Au–V alloy showed significantly enhanced mechanical properties, with a yield strength of 168 MPa, an ultimate tensile strength of 233 MPa, and an elongation of 17%. Immersion test indicated that the degradation rate of the Zn–Ag–Au–V alloy in Dulbecco’s phosphate buffered saline was approximately 7.34 ± 0.64 μm/year, thus being slightly lower than that of pure Zn. Biocompatibility tests with L929 and Saos-2 cells showed a moderate cytotoxicity, alloy extracts at 16.7%, and 10% concentration did not affect metabolic activity and cell proliferation. Plaque formation in vitro was reduced, the Zn–Ag–Au–V surface inhibited adhesion and biofilm formation by the early oral colonizer Streptococcus gordonii, indicating antibacterial properties of the alloy.

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Section: Microstructure and Mechanical Propertiesmentioning

confidence: 99%

Section: In Vitro Degradation Behaviormentioning

confidence: 99%