Investigation of vascular endothelial growth factor (VEGF) polymorphism in patients with idiopathic heavy menstrual bleeding

Abstract

Purpose: To investigate whether there is a relationship between the VEGF gene polymorphisms and idiopathic heavy menstrual bleeding (HMB-E).Methods: 65 patients diagnosed with HMB-E according to the FIGO classi cation system and 65 female healty volunteers were included in the study. Detection of rs699947 (-2578C>A), rs1570360 (-1154G>A), rs2010963 (+405G>C), rs3025039 (+936C>T), rs25648 (c534C>T) polymorphic regions of the VEGF gene was performed by Next Generation DNA Sequencing method.Results: the -2578C>A polymorphic region CC, CA+AA genotypes, and C allele, as well as the -1154G>A polymorphic region AA genotype, and A allele were associated with increased risk of HMB-E (all p<0.05). However, no statistically signi cant difference was found between the the patient group and the control group in terms of genotype and allele distributions in the 405G>C, +936C>T, c534C>T polymorphic regions (all p>0.05). While the -2578/-1154/+405/c534 AGGC haplotype decreased the risk of HMB-E, CAGC haplotype was found to increase the risk of HMB-E. Conclusion: VEGF -2578C>A and -1154G>A polymorphisms were signi cantly associated with the risk of HMB-E in the Turkish population.