Investigation of Urinary Sestrin2 in Patients with Obstructive Sleep Apnea

Bai, Lu; Sun, Chunying; Zhai, Huifen; Chen, Chen; Xiao-tian, HU; Ye, Xiulin; Li, Min; Yan, Fang; Ye, Weimin; Wang, Haoyan; Sun, Shibo

doi:10.1007/s00408-019-00205-8

Cited by 15 publications

(16 citation statements)

References 45 publications

(39 reference statements)

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“…Sestrin2, a typical member of the sestrin family, is the main component of the systemic antioxidant defense mechanism. Recent studies have shown that sestrin2 is involved in many oxidative stress-related respiratory diseases [9][10][11], including COPD. Previous studies on sestrin2 in COPD have primarily focused on animal pulmonary emphysema.…”

Section: Introductionmentioning

confidence: 99%

Correlation between sestrin2 expression and airway remodeling in COPD

Zhang

Wei

et al. 2020

BMC Pulm Med

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Background Airway remodeling is a major pathological characteristic of chronic obstructive pulmonary disease (COPD), and has been shown to be associated with oxidative stress. Sestrin2 has recently drawn attention as an important antioxidant protein. However, the underlying correlation between sestrin2 and airway remodeling in COPD has yet to be clarified. Methods A total of 124 subjects were enrolled in this study, including 62 control subjects and 62 COPD patients. The pathological changes in airway tissues were assessed by different staining methods. The expression of sestrin2 and matrix metalloproteinase 9 (MMP9) in airway tissues was monitored by immunohistochemistry. Enzyme-linked immunosorbent assays (ELISAs) were used to detect the serum concentrations of sestrin2 and MMP9. The airway parameters on computed tomography (CT) from all participants were measured for evaluating airway remodeling. The relationship between serum sestrin2 and MMP9 concentration and airway parameters in chest CT was also analyzed. Results In patients with COPD, staining of airway structures showed distinct pathological changes of remodeling, including cilia cluttered, subepithelial fibrosis, and reticular basement membrane (Rbm) fragmentation. Compared with control subjects, the expression of sestrin2 and MMP9 was significantly increased in both human airway tissues and serum. Typical imaging characteristics of airway remodeling and increased airway parameters were also found by chest CT. Additionally, serum sestrin2 concentration was positively correlated with serum MMP9 concentration and airway parameters in chest CT. Conclusion Increased expression of sestrin2 is related to airway remodeling in COPD. We demonstrated for the first time that sestrin2 may be a novel biomarker for airway remodeling in patients with COPD.

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Section: Introductionmentioning

confidence: 99%

Correlation between sestrin2 expression and airway remodeling in COPD

Zhang

Wei

et al. 2020

BMC Pulm Med

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“…Furthermore, sestrin2 levels have been reported to decline after treatment in Parkinson's, asthma and obstructive sleep apnea (OSA) (9,11,40). We did not follow up on the changes in serum sestrin2 and MMP9 concentration and quantitative airway parameters on chest CT in patients with COPD after regular treatment.…”

Section: Discussionmentioning

confidence: 99%

“…Sestrin2, a leading member of sestrins, is the main component of the systemic antioxidant defense mechanism. Recent studies show sestrin2 is involved in many oxidative stressrelated respiratory diseases (9)(10)(11), including COPD. It was found that sestrin2 is upregulated and can suppress the progression of pulmonary emphysema in mouse models of COPD (12).However, whether there is a potential relationship between sestrin2 and airway remodeling in COPD remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Sestrin2 Was Involved in Airway Remodeling in COPD: A Multi-level Research

Zhang¹,

Wei²,

Ji³

et al. 2020

Preprint

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Background. Airway remodeling is a major pathological characteristic of chronic obstructive pulmonary disease (COPD), which is greatly associated with oxidative stress. Sestrin2 has recently drawn attention as a representative antioxidant protein. However, the underlying correlation between sestrin2 and airway remodeling in COPD has not yet been clarified.Methods. A total of 124 subjects were enrolled in this study, including 62 control subjects and 62 COPD patients. The pathological changes in airway tissues were showed by different staining methods. The expression of sestrin2 and matrix metalloproteinase 9 (MMP9) in airway tissues was assessed by Immunohistochemistry staining. Enzyme-linked immunosorbent assay (ELISA) was used to detect the serum concentrations of sestrin2 and MMP9. The airway parameters on computed tomography (CT) of all participants were measured for the evaluation of airway remodeling. Serum sestrin2 concentrations' relationship with MMP9 and airway parameters on chest CT was further analyzed. Results. In patients with COPD, staining results of airway structure showed noticeable pathological changes of remodeling, including cilia cluttered, subepithelial fibrosis, and reticular basement membrane (Rbm) fragmentation. Compared with control subjects, the expression of sestrin2 and MMP9 was significantly increased in both human airway tissues and serum. Typical imaging characteristics of airway remodeling and increased airway parameters were found on chest CT. Additionally, the serum sestrin2 concentration was positively correlated with serum MMP9 concentration and airway parameters on chest CT.Conclusion. Increased expression of sestrin2 is related to airway remodeling in COPD at three levels including histology, biomarkers and imaging. It is demonstrated for the first time that sestrin2 may be a novel biomarker for airway remodeling in COPD.

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“…First, due to the fact most patients with mild COPD are unaware of their condition or never receive regular lung function tests, our subjects were mostly patients with moderate to severe COPD. Furthermore, sestrin2 levels have been reported to decline after treatment in Parkinson's disease, asthma and obstructive sleep apnea (9,11,46). We did not follow up on the changes in serum sestrin2 and MMP9 concentrations or quantitative airway parameters in chest CT in patients with COPD after regular treatment.…”

Section: Discussionmentioning

confidence: 99%

Correlation between sestrin2 expression and airway remodeling in COPD

Zhang

Wei

et al. 2020

Preprint

View full text Add to dashboard Cite

Background. Airway remodeling is a major pathological characteristic of chronic obstructive pulmonary disease (COPD), and has been shown to be associated with oxidative stress. Sestrin2 has recently drawn attention as an important antioxidant protein. However, the underlying correlation between sestrin2 and airway remodeling in COPD has yet to be clarified.Methods. A total of 124 subjects were enrolled in this study, including 62 control subjects and 62 COPD patients. The pathological changes in airway tissues were assessed by different staining methods. The expression of sestrin2 and matrix metalloproteinase 9 (MMP9) in airway tissues was monitored by immunohistochemistry. Enzyme-linked immunosorbent assays (ELISAs) were used to detect the serum concentrations of sestrin2 and MMP9. The airway parameters on computed tomography (CT) from all participants were measured for evaluating airway remodeling. The relationship between serum sestrin2 and MMP9 concentration and airway parameters in chest CT was also analyzed.Results. In patients with COPD, staining of airway structures showed distinct pathological changes of remodeling, including cilia cluttered, subepithelial fibrosis, and reticular basement membrane (Rbm) fragmentation. Compared with control subjects, the expression of sestrin2 and MMP9 was significantly increased in both human airway tissues and serum. Typical imaging characteristics of airway remodeling and increased airway parameters were also found by chest CT. Additionally, serum sestrin2 concentration was positively correlated with serum MMP9 concentration and airway parameters in chest CT.Conclusion. Increased expression of sestrin2 is related to airway remodeling in COPD. We demonstrated for the first time that sestrin2 may be a novel biomarker for airway remodeling in patients with COPD.

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Investigation of Urinary Sestrin2 in Patients with Obstructive Sleep Apnea

Cited by 15 publications

References 45 publications

Correlation between sestrin2 expression and airway remodeling in COPD

Correlation between sestrin2 expression and airway remodeling in COPD

Sestrin2 Was Involved in Airway Remodeling in COPD: A Multi-level Research

Correlation between sestrin2 expression and airway remodeling in COPD

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