Investigation of Uraemic Thrombopathy

Miguel, J García San; Castillo, Rodrigo

doi:10.1159/000208893

Cited by 8 publications

(5 citation statements)

References 5 publications

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“…Following SPK with restoration of euglycemia, the lipid profile usually normalizes (18) or is treated when necessary with lipid‐lowering medications. Although the uremic effect on platelets (4) could offset the hypercoagulability associated with diabetes mellitus, our experience suggests it doesn't.…”

Section: Discussionmentioning

confidence: 81%

“…Hyperlipidemia, commonly associated with diabetes mellitus, contributes to the hypercoagulable state (3). The development of ESRD, secondary to diabetic nephropathy is felt to confer a certain degree of protection from hypercoagulability, because of the effect of uremia on platelets (4). However, there is evidence that renal failure itself represents a state of hypercoagulability (5), and that ESRD secondary to type 1 IDDM, in fact, represents a significantly hypercoagulable state (6).…”

mentioning

confidence: 99%

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Hypercoagulable state associated with kidney–pancreas transplantation. Thromboelastogram‐directed anti‐coagulation and implications for future therapy

Burke¹,

Ciancio²,

Figueiro

et al. 2004

Clinical Transplantation

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Section: Discussionmentioning

confidence: 81%

mentioning

confidence: 99%

Hypercoagulable state associated with kidney–pancreas transplantation. Thromboelastogram‐directed anti‐coagulation and implications for future therapy

Burke¹,

Ciancio²,

Figueiro

et al. 2004

Clinical Transplantation

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“…40 Bleeding Time and Platelet Function Analyses (Adhesion, Secretion, and TXA 2 Generation) Bleeding times were predominantly assessed using the Ivy bleeding time method. Most studies (ten out of 14) showed a prolongation of the bleeding time in patients with CKD, 25,27,[45][46][47][48][49][50][51][52] whereas only four out of 14 studies reported bleeding times to be normal. [53][54][55][56] Of all these studies, six also reported hemoglobin and/or hematocrit values.…”

Section: Platelet Count Volume and Receptor Expressionmentioning

confidence: 99%

“…25,27,45,51,53,56 In accordance with an overall prolongation of bleeding time, platelet adhesion to glass was reported to be decreased in ten out of 12 studies. 28,45,46,50,51,55,[57][58][59][60] Platelet adhesion under flow to a membrane coated with collagen and ADP (platelet function analyzer-100) was decreased in CKD5 patients in comparison to healthy controls, whereas adhesion to a membrane coated with collagen and epinephrine was unchanged. 32 Regarding secretion, granular content and TXA 2 generation, eight out of 15 studies found the levels of CKD platelets to be comparable to those of healthy platelets, 27,33,40,57,62,63,66,68,69 whereas others reported a decreased level of serotonin secretion, ADP/ATP granular content, and TXA 2 generation.…”

Section: Platelet Count Volume and Receptor Expressionmentioning

confidence: 99%

Platelet Function in CKD: A Systematic Review and Meta-Analysis

Baaten

Sternkopf

Henning

et al. 2021

JASN

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BackgroundPatients with CKD are at high risk for thrombotic and hemorrhagic complications. Abnormalities in platelet function are central to these complications, but reports on platelet function in relation to CKD are conflicting, and vary from decreased platelet reactivity to normal or increased platelet responsiveness. The direct effects of uremic toxins on platelet function have been described, with variable findings.MethodsTo help clarify how CKD affects platelet function, we conducted a systematic review and meta-analysis of platelet activity in CKD, with a focus on nondialysis-induced effects. We also performed an extensive literature search for the effects of individual uremic toxins on platelet function.ResultsWe included 73 studies in the systematic review to assess CKD’s overall effect on platelet function in patients; 11 of them described CKD’s effect on ex vivo platelet aggregation and were included in the meta-analysis. Although findings on platelet abnormalities in CKD are inconsistent, bleeding time was mostly prolonged and platelet adhesion mainly reduced. Also, the meta-analysis revealed maximal platelet aggregation was significantly reduced in patients with CKD upon collagen stimulation. We also found that relatively few uremic toxins have been examined for direct effects on platelets ex vivo; ex vivo analyses had varying methods and results, revealing both platelet-stimulatory and inhibitory effects. However, eight of the 12 uremic toxins tested in animal models mostly induced prothrombotic effects.ConclusionsOverall, most studies report impaired function of platelets from patients with CKD. Still, a substantial number of studies find platelet function to be unchanged or even enhanced. Further investigation of platelet reactivity in CKD, especially during different CKD stages, is warranted.

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“…However, in an extensive investigation during the years 1965-1966. com prising 13,000 men aged [50][51][52][53][54][55][56][57][58][59]. N a tv ig et at.…”

Section: Aim O F the Investigationmentioning

confidence: 99%

An Investigation of the Platelet Adhesiveness by Hellem’s Method in Elderly Patients under Longterm Psychiatric Care, on a Controlled Diet with an Unsaturated Fatty Acid Load

Bentzen¹,

Jacobsen²,

Munch-Petersen³

1972

Geront clin

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After briefly reviewing the literature, a material is presented comprising 78 elderly patients under psychiatric long-term care, who are on a controlled diet. Using a double-blind technique, determinations of platelet adhesiveness are made on 63 of the patients, using the glass bead column method of Hellem, before and after treatment for 1 and 3 weeks with linolenic acid and linolic acid. The accuracy of the method during counting in a Coulter counter is evaluated and found to be satisfactory. Ten determinations are made at intervals of a few days in each of 10 patients and show that with the method employed, the platelet content in platelet-rich plasma (PRP) is not subjected to spontaneous variation at a significant level. Ten determinations of adhesiveness are made on each of 10 patients at intervals of a few days and show a moderate but acceptable spontaneous variation in the individual patient. The clinical reproducibility of the method is found to be acceptable when paired comparisons are made with the individual patient as his own control. A significant reduction is demonstrated in platelet adhesiveness after treatment for 1 week with linolenic acid (p < 0.001). After treatment for 3 weeks with linolenic acid, a significant rise in the platelet adhesiveness is found (p < 0.001) (‘rebound’ phenomenon?), which hereafter tapers off steadily during the treatment-free period to reach the initial level in the course of the 5th week. With linolic acid treatment, no significant change in platelet adhesiveness is found after treatment for 1 week (p < 0.20). After treatment for 3 weeks, a moderate but significant fall (p < 0.05) is found. After 1 week without treatment (4th week), a significant fall in adhesiveness is found (p < 0.02), while the adhesiveness in the course of the 5th week rises to the neighbourhood of the initial level. The hypothesis is presented that there may be a difference in principle between the effect of linolenic acid and linolic acid on platelet adhesiveness. Further investigations on this will require prolonged experimental treatment.

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Investigation of Uraemic Thrombopathy

Cited by 8 publications

References 5 publications

Hypercoagulable state associated with kidney–pancreas transplantation. Thromboelastogram‐directed anti‐coagulation and implications for future therapy

Hypercoagulable state associated with kidney–pancreas transplantation. Thromboelastogram‐directed anti‐coagulation and implications for future therapy

Platelet Function in CKD: A Systematic Review and Meta-Analysis

An Investigation of the Platelet Adhesiveness by Hellem’s Method in Elderly Patients under Longterm Psychiatric Care, on a Controlled Diet with an Unsaturated Fatty Acid Load

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