Investigation of thermal damage of tissues embedded with large blood vessels during plasmonic photo-thermal heating (PPTH)

Paul, Anup; Narasimhan, Arunn; Das, Sarit K.

doi:10.1108/hff-01-2015-0032

Cited by 7 publications

(5 citation statements)

References 32 publications

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“…Simulations [41] have shown that using gold nanoparticles for photothermal treatments enables the containment of the temperature to a much narrower field than using laser irradiation only, also in the presence of large blood vessels that act as heat sinks. [42] This could be confirmed during in vivo photothermal experiments [43] where the enhanced optical extinction confined the source of the resultant heat to nanoparticle-containing tissue. This resulted in a steep temperature gradient at the tumor boundary that confines thermal damage to the target tissue.…”

Section: Particle-based Controlled Heatingmentioning

confidence: 82%

Precision in Thermal Therapy: Clinical Requirements and Solutions from Nanotechnology

Gschwend

Hintze

Herrmann

et al. 2021

Advanced Therapeutics

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The heating of diseased tissue as a therapeutic measure has gained increased clinical attention, mostly due to its target-specificity that minimizes side effects. However, to ensure a successful therapy, heating has to be homogeneous and highly localized, as well as, within a certain temperature range. Therefore, precise control over thermal treatments is a clinical prerequisite to minimize treatment and safety margins. Although this requirement is mentioned frequently, past research has focused predominantly on improving thermometry resolution and heating efficiency through tedious material optimization. Here, current clinical applications of thermal therapy with their challenges are first highlighted, especially with respect to treatment control and margins. Thereafter, it is quantitatively shown that clinically available thermometry fulfills the requirements and future research should focus on achieving better temperature control instead. With nanotechnology, novel strategies based on self-limiting nanoparticle systems and particle-based thermometers with active feedback control have also become available and are discussed. All of these approaches are systematically compared and analyzed with respect to their clinical applicability. The extent to which control over thermal therapy is necessary is also discussed alongside a presentation of the existing methods which fulfill the set requirements for clinical success and what issues remain to be tackled by research in the near future.

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Section: Particle-based Controlled Heatingmentioning

confidence: 82%

Precision in Thermal Therapy: Clinical Requirements and Solutions from Nanotechnology

Gschwend

Hintze

Herrmann

et al. 2021

Advanced Therapeutics

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“…We assessed the impact of a blood vessel on LITT outcomes, assuming the vessel acts as a heat sink. Prior investigations, such as the work by Verhey et al and Paul et al have shown that the presence of large vessels may result in asymmetric temperature and thermal damage results in response to LITT [9,11,12,20]. In building on this work, we examined the impact of the vessel on a clinically relevant treatment planning scenario.…”

Section: Discussion and Next Stepsmentioning

confidence: 99%

“…This is in line with the notion that vessels under a certain size, which have a smaller capacity to carry away heat, end up being completely occluded during treatment. Several investigators built on this work by developing their own models that consider more complex flow patterns and cases with multiple vessels [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Laser interstitial thermal therapy of lung lesions near large vessels: a numerical study

Effat

Bernards

Gregor

et al. 2023

Biomed. Phys. Eng. Express

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Objective. Laser interstitial thermal therapy (LITT) is an evolving hyperthermia-based technology that may offer a minimally invasive alternative to inoperable lung cancer. LITT of perivascular targets is challenged by higher risk of disease recurrence due to vascular heat sinks, as well as risk of damage to these vascular structures. The objective of this work is to examine the impact of multiple vessel parameters on the efficacy of the treatment and the integrity of the vessel wall in perivascular LITT. Approach. A finite element model is used to examine the role of vessel proximity, flow rate, and wall thickness on the outcome of the treatment.. Main Result. The simulated work indicates that vessel proximity is the major factor in driving the magnitude of the heat sink effect. Vessels situated near the target volume may act as a protective measure for reducing healthy tissue damage. Vessels with thicker walls are more at risk of damage during treatment. Interventions to reduce the flow rate may reduce the vessel’s heat sink effect but may also result in increased risk of vascular wall damage. Lastly, even at reduced blood flow rates, the volume of blood reaching the threshold of irreversible damage (>43°C) is negligible compared to the volume of blood flow throughout the treatment duration. Significance. This investigative simulation yields results that may help guide clinicians on treatment planning near large vessels.

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“…PDT/PTT synergistic therapy can improve the therapeutic efficacy and may provide a promising strategy for ablating the complicated and metastatic malignancies while minimizing side effects. [137][138][139] Gan et al developed indocyanine green@covalent organic framework-1@polydopamine (ICG@COF-1@PDA) nanosheets as phototherapeutic agents for PDT/PTT dual-modal tumour therapy. 98 ICG@COF-1@PDA improved tumour elimination to release abundant endogenous tumour neoantigens, thus triggering effective anti-tumour immune responses (Fig.…”

Section: Chem Soc Rev Tutorial Reviewmentioning

confidence: 99%

Advancing nanotechnology for neoantigen-based cancer theranostics

Zou,

Zhang,

Pan

et al. 2024

Chem. Soc. Rev.

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Investigation of thermal damage of tissues embedded with large blood vessels during plasmonic photo-thermal heating (PPTH)

Cited by 7 publications

References 32 publications

Precision in Thermal Therapy: Clinical Requirements and Solutions from Nanotechnology

Precision in Thermal Therapy: Clinical Requirements and Solutions from Nanotechnology

Laser interstitial thermal therapy of lung lesions near large vessels: a numerical study

Advancing nanotechnology for neoantigen-based cancer theranostics

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