Investigation of the utility of Curcuma caesia in the treatment of diabetic neuropathy

Abstract

Objectives Curcuma caesia has shown positive results in treating number of diseases, but till date no work was reported on its activity in diabetic neuropathy. So, the present review aims at exploring several hypothesis which can be proposed to explain further its utility in diabetic neuropathy by its antioxidant property, anti‐inflammatory, CNS depressant effect, antibacterial and antifungal property. For finding the accurate and exact detail, a thorough review of all the available research and review article was done. A number of book chapters and encyclopaedias were taken into consideration to find out the origin, botany and genetics. The databases were searched using different keywords like antioxidant, inflammation, turmeric, diabetic neuropathy. Key findings After getting data on pathogenesis of diabetic neuropathy, it has been found out that its role as antioxidant will reduce the level of oxidative stress which is the main reason for the occurrence of the present complication. Apart this, the anti‐inflammatory activity will further prevent the inflammation of neurons and antibacterial effect will inhibit the spread of infection. Combining all the factors together, the plant can be utilized in the treatment of diabetic neuropathy. Summary Curcuma caesia can be proved as a useful approach in the treatment of diabetic neuropathy.

Impact of chrysin on the molecular mechanisms underlying diabetic complications

“…Hyperglycemia induces significant metabolic and enzymatic modifications and also release of neuroinflammatory cytokines (TNF-α, IL-6, IL-1); (Callaghan & Feldman, 2013). Additionally, neuroinflammation and oxidative stress are the main mechanisms for induction of injury in the diabetic tissues (Samarghandian, Azimi-Nezhad, Samini & Farkhondeh, 2015;Grover, Shah, Khullar, Gupta, & Behl, 2019). Chronic hyperglycemia caused oxidative damage in nervous tissue in experimental models.…”

Ameliorative Effects of Isoeugenol and Eugenol against Impaired Nerve Function and Inflammatory and Oxidative Mediators in Diabetic Neuropathic Rats

“…If the glycemic deficit persists, combination therapy may be considered for these patients, as it is for patients with cancer and diabetic neuropathic pain [ 57 , 58 ]. It is possible to conclude that isoeugenol and eugenol in combination exerted a better antinociceptive effect in terms of mechanical allodynia and hyperalgesia, thermal hyperalgesia, and cold allodynia in diabetic rats by suppressing oxidative stress and inflammation [ 59 ].…”

Extraction of bioactive compounds from Curcuma longa L. using deep eutectic solvents: In vitro and in vivo biological activities

“…Numerous studies and review articles evidenced the high capacity of bioactive compounds present in Curcuma longa L. to act as antioxidant, anti-inflammatory, antibacterial, and anti-carcinogenic agents. Also, several studies report its use as herbal medicine, helping to prevent diseases and premature aging (Bavarsad, Matbou, Saadat, & Barreto, 2019;Grover, Shah, Khullar, Gupta, & Behl, 2019;Kwiecien, Magierowski, Majka, & Ptak-belowska, 2019;Salehi et al, 2019).…”