Investigation of the Temperature-Sensitive Characteristic of Grafted Gelatin-Pluronic Hydrogel With Incorporation Calophyllum Inophyllum Oil Extract Applied for Wound Healing

Abstract

Temperature-sensitive hydrogels were synthesized from gelatin-pluronic F127 with Calophyllum inophyllum oil extract incorporated as the the active ingredient by ultrasonic waves to increase the healing effect of wound treatments. The temperaturesensitive nature of the hydrogels were determined using the inversion tube method along with rheological property measurements. The sol-gel state of the hydrogels were found to change with temperature, at low-temperatures hydrogel gelatin - pluronic F127 is found to be in a liquid state, and when the temperature raised due to body temperature the hydrogel became a gel film. In addition, the hydrogel containing Calophyllum inophyllum oil has the ability to heal burns in the second degree after 10days of treatment. These results showed the potential application of the biomaterial in tissue regeneration.