Investigation of the temperature responsive behaviors of novel polyaspartamide derivatives bearing alkyl ether-type pendants

Zhang, Guangyan; Bao, Chenhui; Yi, Hui

doi:10.1016/j.arabjc.2021.103287

Cited by 1 publication

(2 citation statements)

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“…For example, oligo(ethylene glycol) (OEG) containing ether oxygen was usually introduced for preparing temperature-responsive polymers, such as OEG methacrylate based polymers [39,40] and polypeptides bearing OEG pendants [41,42]. In 2021, linear alkyl ether-type amine compounds, which contain one ether oxygen and varying carbon atoms, were successfully used for the synthesis of temperature-responsive PAS-PAm derivatives bearing alkyl ether-type pendants [43]. The composition of temperatureresponsive PASPAm derivatives and their LCSTs are summarized in Table 1.…”

Section: Temperature-responsive Poly(aspartamide) Derivativesmentioning

confidence: 99%

“…Interestingly, it has been reported that some temperature-responsive PASPAm derivatives also exhibit pH responsiveness even without introducing pH-responsive functional groups or pH-cleavable linkages. The pH responsiveness of temperature-responsive PAS-PAm derivatives may be related to the presence of hydroxyl groups in alkanolamide pendants [36] or the end groups (carboxyl and amine groups) of PASPAm backbone [43].…”

Section: Ph-responsive Poly(aspartamide) Derivativesmentioning

confidence: 99%

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Stimuli-Responsive Poly(aspartamide) Derivatives and Their Applications as Drug Carriers

Zhang

Bao

2021

IJMS

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Poly(aspartamide) derivatives, one kind of amino acid-based polymers with excellent biocompatibility and biodegradability, meet the key requirements for application in various areas of biomedicine. Poly(aspartamide) derivatives with stimuli-responsiveness can usually respond to external stimuli to change their chemical or physical properties. Using external stimuli such as temperature and pH as switches, these smart poly(aspartamide) derivatives can be used for convenient drug loading and controlled release. Here, we review the synthesis strategies for preparing these stimuli-responsive poly(aspartamide) derivatives and the latest developments in their applications as drug carriers.

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