“…This mechanism could explain the necessary flexibility of the link between the N and C-terminal domains of TnC. 54,55 Finally, we note a report of a crystal structure of chicken skeletal muscle troponin TnC-TnI-TnT2 ternary complex in the CCa 2C state (M. V. Vinogradova et al, unpublished results). Our structure for the CCa 2C state is in agreement with this crystal structure, in which TnC adopts a dumbbell conformation.…”