Investigation of the shared gene signatures and molecular mechanisms between obstructive sleep apnea syndrome and asthma

Que, Yifan; Meng, Hao; Ding, Yongkai; Fan, Jiao; Du, Yingzhen; Xu, Guogang

doi:10.1016/j.gene.2023.148029

Cited by 3 publications

(1 citation statement)

References 56 publications

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“…and their respiratory resistance was measured under increasing concentrations of acetylcholine (0, 6, 12, 24, and 48 mg/mL), with the results recorded and expressed as resistance of the respiratory system (Rrs). 30 Throughout the Rrs measurement process, the respiratory condition of mice was continuously monitored, and no signs of respiratory distress were observed. Statistical analysis of the results was conducted using GraphPad Prism 8.0 software, employing the Two‐Way Analysis of Variance (ANOVA) statistical method.…”

Section: Methodsmentioning

confidence: 99%

Intermittent hypoxic pretreatment exacerbates house dust mite‐induced asthma airway inflammation

Meng,

Zhang,

Que

et al. 2024

Immunity Inflam & Disease

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BackgroundAsthma is widely recognized as an inflammatory disorder. In the context of this inflammatory microenvironment, the involvement of hypoxia and its impact on related pathways have drawn considerable attention. However, the exact role of hypoxia, a prevalent environmental factor, in the development and progression of asthma remains poorly understood.MethodsMice were treated with house dust mite (HDM) extracts for 23 days to induce asthma. Mice were divided into room air (RA) group and intermittent hypoxic (IH) group by exposing to different conditions and IH preconditioning (IHP) were underwent to the above groups before the hypoxic regimen. Airway inflammation in mice was evaluated by airway hyperresponsiveness, excessive mucus secretion, and recruitment of inflammatory cells. Immunohistochemistry was employed to quantify the expression levels of NF‐κB. Subsequently, the dose of allergen was modified to investigate whether the impact of hypoxia on asthma is affected by different doses of allergens.ResultCompared to the RA and IH groups, HDM‐treated mice in the IHP group exhibited aggravated inflammatory cell infiltration and airway hyperresponsiveness (p＜.05). Moreover, there was an increased release of inflammatory mediators and higher expression levels of NF‐κB (p＜.05). Importantly, the impact ia on asthma was found to be influenced by high dose of allergen (p＜.05).ConclusionIHP treatment potentially exacerbates HDM‐induced airway inflammation in asthma, with the involvement of NF‐κB, particularly under high‐dose allergen stimulation.

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Section: Methodsmentioning

confidence: 99%

Intermittent hypoxic pretreatment exacerbates house dust mite‐induced asthma airway inflammation

Meng,

Zhang,

Que

et al. 2024

Immunity Inflam & Disease

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Contribution of Obstructive Sleep Apnea to Asthmatic Airway Inflammation and Impact of Its Treatment on the Course of Asthma

Ioachimescu

2024

Sleep Medicine Clinics

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State of the art: Alternative overlap syndrome—asthma and obstructive sleep apnea

Ioachimescu

2024

Journal of Investigative Medicine

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In the general population, Bronchial Asthma (BA) and Obstructive Sleep Apnea (OSA) are amongst the most prevalent chronic respiratory disorders. Significant epidemiologic connections and complex pathogenetic pathways link these disorders via complex interactions at genetic, epigenetic and environmental levels. The coexistence of BA and OSA in an individual likely represents a distinct syndrome, i.e., a collection of clinical manifestations attributable to several mechanisms and pathobiological signatures. To avoid terminological confusion, this association has been named alternative overlap syndrome (vs overlap syndrome represented by the chronic obstructive pulmonary disease - OSA association). This comprehensive review summarizes the complex, often bidirectional links between the constituents of the alternative overlap syndrome. Cross-sectional, population or clinic-based studies are unlikely to elucidate causality or directionality in these relationships. Even longitudinal epidemiological evaluations in BA cohorts developing over time OSA, or OSA cohorts developing BA during follow-up cannot exclude time factors or causal influence of other known or unknown mediators. As such, a lot of pathophysiological interactions described here have suggestive evidence, biological plausibility, potential or actual directionality. By showcasing existing evidence and current knowledge gaps, the hope is that deliberate, focused and collaborative efforts in the near-future will be geared towards opportunities to shine light on the unknowns, and accelerate discovery in this field of health, clinical care, education, research and scholarly endeavors.

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Investigation of the shared gene signatures and molecular mechanisms between obstructive sleep apnea syndrome and asthma

Cited by 3 publications

References 56 publications

Intermittent hypoxic pretreatment exacerbates house dust mite‐induced asthma airway inflammation

Intermittent hypoxic pretreatment exacerbates house dust mite‐induced asthma airway inflammation

Contribution of Obstructive Sleep Apnea to Asthmatic Airway Inflammation and Impact of Its Treatment on the Course of Asthma

State of the art: Alternative overlap syndrome—asthma and obstructive sleep apnea

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