Investigation of the Role of Histamine in Antigen‐induced Bronchoconstriction in the Ascaris‐hypersensitive Dog

Krell, Robert D.

doi:10.1111/j.1476-5381.1978.tb07756.x

Cited by 21 publications

(5 citation statements)

References 18 publications

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“…In contrast to asthma in man, AHR in Basenji greyhounds is not associated with clinical symptoms. Dogs can be sensitized by natural exposure to Ascaris suum, but they can also be immunized by either with the same [235] or with other antigens (e.g. ragweed) [236].…”

Section: Dogmentioning

confidence: 99%

Current Animal Models of Bronchial Asthma

Kurucz¹,

Szelenyi²

2006

CPD

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Human asthma is on the rise worldwide. The necessity to develop effective treatments against it requires an organized effort which covers every aspect of the disease from the pathological alterations via the genetic background to the use and development of active remedies. In these processes animal experiments have served an indispensable role. As asthma is not a natural disease in the animal kingdom the variety for artificially established animal models is quite wide. The possible selection ranges from the laboratory mouse to the horse, it includes ferret and sheep and even favorite pets such as cats and dogs. The large number of the models indicates that to some extent they might not be appropriate or it means that there is no generally accepted model of human asthma. Whatever the reason for this diversity animal models helped us to understand the detailed pathogenesis of some aspects of the disease, they helped us to develop compounds which are more active then previously used ones, and these models proved to us that human asthma is a unique, possibly species-specific disease the eradication of which requires a huge effort. This enormous task should include the collaboration of the clinical and basic research for the development of improved, advanced animal models, which in turn could strengthen our understanding about human asthma.

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Section: Dogmentioning

confidence: 99%

Current Animal Models of Bronchial Asthma

Kurucz¹,

Szelenyi²

2006

CPD

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“…The exact mechanisms of initiation, tachyphylaxis and recovery of the Schultz-Dale reaction are still largely unknown (Chand & Eyre, 1978a). However, the release of potent chemical mediators like slow reacting substance of anaphylaxis (SRS-A, Brocklehurst, 1960;Krell & Chakrin, 1977;1978), PGF23 (Vane, 1971), endoperoxides or thromboxanes (Chijimatsu, Nguyen & Said, 1977;Piper, 1977) and bradykinin from the sensitized mast cells which are found in abundance in canine peripheral airways (Meyer et al, 1973), may account for the anaphylactic reaction in the lung strip.…”

Section: Discussionmentioning

confidence: 99%

“…Dogs have frequently been used as a model for allergic asthma in man (Booth, Gold, Kessler, Yu & Frick, 1972;Meyers, Dain, Gold, Miller & Bourne, 1977;Krell & Chakrin, 1976;1977;1978;Krell, 1978). In the present investigation we evaluated the lung strip as an in vitro model for canine asthma and studied its reactivity to antigen and some autonomic and autacoid agents.…”

Section: Introductionmentioning

confidence: 99%

PHARMACOLOGY OF SCHULTZ‐DALE REACTION IN CANINE LUNG STRIP in vitro: POSSIBLE MODEL FOR ALLERGIC ASTHMA

Chand

DeRoth

Eyre

1979

British J Pharmacology

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1 Isolated lung parenchymal strips of the dog contracted in response to histamine > carbachol > prostaglandin F2 , (PGF2#J> bradykinin (Bk) > 5-hydroxytryptamine (5-HT). The order of the relative activity of these agents on the tracheobronchial smooth muscles (TBSM) was carbachol'> 5-HT > histamine; PGF2. and Bk were inactive. Thus there are marked differences in the responsiveness of the smooth muscle of central (trachea and bronchus) and peripheral (lung strip) airways to autonomic and autacoid agents. 2 Lung strips and TBSM partially contracted by carbachol, histamine or horse plasma, were relaxed by isoprenaline, PGE1 and PGE2. 3 Lung strips from dogs sensitized to horse-plasma contracted in response to antigen (Schultz-Dale anaphylactic reaction). Tachyphylaxis or desensitization to subsequent antigen challenge was invariably observed; it was followed after 1 to 2 h of rest by partial recovery of the anaphylactic response.

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“…Dogs have frequently been used as a model for allergic asthma in man (Booth, Patterson & Talbot, 0007-1188/79/080511-06 $01.00 1970; Gold, Kessler, Yu & Frick, 1972;Meyers, Dain, Gold, Miller & Bourne, 1977;Krell & Chakrin, 1976;1977;1978;Krell, 1978). In the present investigation we evaluated the lung strip as an in vitro model for canine asthma and studied its reactivity to antigen and some autonomic and autacoid agents.…”

Section: Introductionmentioning

confidence: 99%

Untitled

1979

British J Pharmacology

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Isolated lung parenchymal strips of the dog contracted in response to histamine > carbachol > prostaglandin F2 , (PGF2#J> bradykinin (Bk) > 5-hydroxytryptamine (5-HT). The order of the relative activity of these agents on the tracheobronchial smooth muscles (TBSM) was carbachol'> 5-HT > histamine; PGF2. and Bk were inactive. Thus there are marked differences in the responsiveness of the smooth muscle of central (trachea and bronchus) and peripheral (lung strip) airways to autonomic and autacoid agents. 2 Lung strips and TBSM partially contracted by carbachol, histamine or horse plasma, were relaxed by isoprenaline, PGE1 and PGE2. 3 Lung strips from dogs sensitized to horse-plasma contracted in response to antigen (Schultz-Dale anaphylactic reaction). Tachyphylaxis or desensitization to subsequent antigen challenge was invariably observed; it was followed after 1 to 2 h of rest by partial recovery of the anaphylactic response.

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Investigation of the Role of Histamine in Antigen‐induced Bronchoconstriction in the Ascaris‐hypersensitive Dog

Cited by 21 publications

References 18 publications

Current Animal Models of Bronchial Asthma

Current Animal Models of Bronchial Asthma

PHARMACOLOGY OF SCHULTZ‐DALE REACTION IN CANINE LUNG STRIP in vitro: POSSIBLE MODEL FOR ALLERGIC ASTHMA

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