Investigation of the radioprotective efficacy of hesperidin against gamma-radiation induced cellular damage in cultured human peripheral blood lymphocytes

Kalpana, K; Nagarajan, Devipriya; Srinivasan, M.; Menon, Venugopal P.

doi:10.1016/j.mrgentox.2009.03.005

Cited by 61 publications

(31 citation statements)

References 48 publications

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“…Radiation therapy is one of the major methods for the treatment of patients with cancerous and vanillin (0.5mM) (Kalpana et al, 2009). These in vitro results are consistent with Park's in vivo findings in which they evaluated the radioprotective activity of Hsd (50 mg/kg and 100 mg/kg orally administered for 7 days) against 1 Gy, 3 Gy and 5 Gy of γ radiation in Sprague-Dawley rats (Pradeep et al, 2008).…”

Section: Radiation Therapysupporting

confidence: 80%

Protective effects of flavonoids against microbes and toxins: The cases of hesperidin and hesperetin

et al. 2015

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Section: Radiation Therapysupporting

confidence: 80%

Protective effects of flavonoids against microbes and toxins: The cases of hesperidin and hesperetin

et al. 2015

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“…While, immunosuppression and potential infections are also important cause of IR induced death 30. However, the influence of ionizing irradiation on the functions of DC, the most potent APC, is largely ignored.…”

Section: Discussionmentioning

confidence: 99%

Gamma-ray Irradiation Impairs Dendritic Cell Migration to CCL19 by Down-regulation of CCR7 and Induction of Cell Apoptosis

Liu¹,

Lin²,

Zhao³

et al. 2011

Int. J. Biol. Sci.

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Dendritic cells (DCs) are the most potent antigen-presenting cells and play a crucial role in the regulation of immune response and migration of DCs into secondary lymphoid tissues also play an important role in the initiation of innate and adaptive immunity. Radiation therapy is now a routine treatment for certain types of cancer and over 20 percent of cancer patients will require radiation therapy during the treatment of their disease. However, the influence of ionizing irradiation on the migratory ability of DCs is largely unknown. In this article, we report that γ ray irradiation can significantly inhibit LPS-triggered up regulation of CCR7 expression and PGE2 production by DC, thus impairing DC migration towards CCL19 in vitro and in vivo. Moreover, γ ray exposed DC also displayed an increased apoptosis rate and decreased cell viability. Furthermore, we demonstrate that exogenous PGE2 can partly reduce the gamma-ray induced migratory impairment and restored CCR7 expression of DC. Our work suggests that γ irradiation affects DC function at multiple steps during the immune response including DC migration, and that PGE2, via control of CCR7 expression, is an important regulator of DC migration.

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“…Among the water-soluble compounds, mint contains flavanoids like rutin, hesperidin, caffeic acid, carnosic acid, carnosol, and rosmarinic acid, which have all been reported to possess radioprotective effects. [59][60][61][62][63][64] It is quite possible that the presence of these compounds in the aqueous extract might have contributed to the observed high DRF of the aqueous extract of mint.…”

Section: Discussionmentioning

confidence: 99%

Radioprotective potential of mint: A brief review

Baliga

Rao

2010

J Can Res Ther

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Radiation is an important modality in cancer treatment and estimates are that between one third and one half of all patients will require ionizing irradiation therapy during some point in their clinical management. However, the radiation-induced damage to the normal tissues restricts the therapeutic doses of radiation that can be delivered to tumors and thereby limits the effectiveness of the treatment. The use of chemical compounds (radioprotectors) represents an obvious strategy to improve the therapeutic index in radiotherapy. However, most of the synthetic radioprotective compounds studied have shown inadequate clinical application owing to their inherent toxicity and high cost. These observations necessitated a search for alternative agents that are less toxic and highly effective. Studies in the recent past have shown that some medicinal plants possess radioprotective effects. Two species of the commonly used aromatic herb mint, Mentha piperita and M. arvensis protected mice against the γ-radiation-induced sickness and mortality. Detail investigations have also shown that the aqueous extract of M. piperita protected the vital radiosensitive organs: the testis, gastrointestinal and hemopoetic systems in mice. The radioprotective effects are possibly due to free radical scavenging, antioxidant, metal chelating, anti-inflammatory, antimutagenic, and enhancement of the DNA repair processes. This review for the first time summarizes the observations and elucidates the possible mechanisms responsible for the beneficial effects. The lacunae in the existing knowledge and directions for future research are also addressed.

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Investigation of the radioprotective efficacy of hesperidin against gamma-radiation induced cellular damage in cultured human peripheral blood lymphocytes

Cited by 61 publications

References 48 publications

Protective effects of flavonoids against microbes and toxins: The cases of hesperidin and hesperetin

Protective effects of flavonoids against microbes and toxins: The cases of hesperidin and hesperetin

Gamma-ray Irradiation Impairs Dendritic Cell Migration to CCL19 by Down-regulation of CCR7 and Induction of Cell Apoptosis

Radioprotective potential of mint: A brief review

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