We de vel oped a new ver sion of the X-PMSP pro gram for es ti mat ing mass stop ping pow ers in charged par ti cle radiotherapy, shield ing of nu clear re ac tors and par ti cle ac cel er a tors, and med ical and en er getic ra dio iso tope pro duc tion. Ac cord ingly, we cal cu lated the mass stop ping powers of im por tant med i cal, in dus trial, and chem i cal com pounds and mix tures de fined by In terna tional Com mis sion on Ra di a tion Units and Mea sure ments us ing the X-PMSP pro gram, to con trib ute to the ex ist ing lit er a ture and com pared our re sults with those from the Na tional Insti tute of Stan dards and Tech nol ogy da ta base. The ap pli ca tion of this pro gram, for par ti cles in the en ergy range 10-50 MeV, will be es pe cially im por tant in the pro duc tion of med i cal ra dio isotopes, as it re duces the max i mum er ror rate to <5 % for pro ton, and to ~1.6 % for al pha par ticles. Fur ther more, the max i mum er ror rates in charged par ti cle ra dio ther apy, at the en ergy range 1-250 MeV, are ~8.2 % for pro tons, and ~3.0 % for al pha par ti cles.