Investigation of the Pristine and Functionalized Carbon Nanotubes as a Delivery System for the Anticancer Drug Dacarbazine: Drug Encapsulation

Mirsalari, Halimeh; Maleki, Afsaneh; Raissi, Heidar; Soltanabadi, Azim

doi:10.1016/j.xphs.2020.10.062

Cited by 30 publications

(14 citation statements)

References 51 publications

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“…Mirsalari et al performed molecular dynamic simulations to study the adsorption of an anticancer drug Dacarbazine (DAC) into the inner and outer surface of pristine and functionalized carbon nanotubes (FCNTs) with four carboxylic acid groups in an aqueous solution. Results depicted that the interaction is controlled by the pi–pi interactions with the special orientation of DAC molecule [ 53 ]. M. Yoosefian and M. Jahani functionalized SWCNTs with the carboxylic group and loaded them with droxidopa which exhibited efficient drug loading via chemisorption with an adsorption energy of − 0.714 eV.…”

Section: Biomedical Applications Of Carbon Nanotubesmentioning

confidence: 99%

Carbon nanotubes in biomedical applications: current status, promises, and challenges

et al. 2022

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In the past decade, there has been phenomenal progress in the field of nanomaterials, especially in the area of carbon nanotubes (CNTs). In this review, we have elucidated a contemporary synopsis of properties, synthesis, functionalization, toxicity, and several potential biomedical applications of CNTs. Researchers have reported remarkable mechanical, electronic, and physical properties of CNTs which makes their applications so versatile. Functionalization of CNTs has been valuable in modifying their properties, expanding their applications, and reducing their toxicity. In recent years, the use of CNTs in biomedical applications has grown exponentially as they are utilized in the field of drug delivery, tissue engineering, biosensors, bioimaging, and cancer treatment. CNTs can increase the lifespan of drugs in humans and facilitate their delivery directly to the targeted cells; they are also highly efficient biocompatible biosensors and bioimaging agents. CNTs have also shown great results in detecting the SARS COVID-19 virus and in the field of cancer treatment and tissue engineering which is substantially required looking at the present conditions. The concerns about CNTs include cytotoxicity faced in in vivo biomedical applications and its high manufacturing cost are discussed in the review. Supplementary Information The online version contains supplementary material available at 10.1007/s42823-022-00364-4.

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Section: Biomedical Applications Of Carbon Nanotubesmentioning

confidence: 99%

Carbon nanotubes in biomedical applications: current status, promises, and challenges

et al. 2022

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“…To address these drawbacks, a nanoparticle-based drug delivery system with multitherapeutic and imaging properties can be used as an effective approach. 5 Various drug delivery nano-systems such as liposomes, 6 copper particles, 7 graphene oxide nanoparticles, 8 and silica nanoparticles have been actively developed to improve the in vivo stability and pharmacokinetics of therapeutic compounds. Among these, mesoporous silica nanoparticles (MSNs) possess unique properties, such as controllable particle size and volume, outstanding loading capability, easy functionalization, and good biocompatibility, which makes them ideal nanocarriers for drug delivery and imaging.…”

Section: Introductionmentioning

confidence: 99%

“…To address these drawbacks, a nanoparticle-based drug delivery system with multitherapeutic and imaging properties can be used as an effective approach. 5 …”

Section: Introductionmentioning

confidence: 99%

Dual Modal Imaging-Guided Drug Delivery System for Combined Chemo-Photothermal Melanoma Therapy

Zhang¹,

Zhang²,

Wu³

et al. 2021

IJN

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Malignant melanoma is one of the most devastating types of cancer with rapid relapse and low survival rate. Novel strategies for melanoma treatment are currently needed to enhance therapeutic efficiency for this disease. In this study, we fabricated a multifunctional drug delivery system that incorporates dacarbazine (DTIC) and indocyanine green (ICG) into manganese-doped mesoporous silica nanoparticles (MSN(Mn)) coupled with magnetic resonance imaging (MRI) and photothermal imaging (PI), for achieving the superior antitumor effect of combined chemo-photothermal therapy. Materials and Methods: MSN(Mn) were characterized in terms of size and structural properties, and drug loading and release efficiency MSN(Mn)-ICG/DTIC were analyzed by UV spectra. Photothermal imaging effect and MR imaging effect of MSN(Mn)-ICG/DTIC were detected by thermal imaging system and 3.0 T MRI scanner, respectively. Then, the combined chemo-phototherapy was verified in vitro and in vivo by morphological evaluation, ultrasonic and pathological evaluation. Results: The as-synthesized MSN(Mn) were characterized as mesoporous spherical nanoparticles with 125.57±5.96 nm. MSN(Mn)-ICG/DTIC have the function of drug loadingrelease which loading ratio of ICG and DTIC could reach to 34.25±2.20% and 50.00±3.24%, and 32.68±2.10% of DTIC was released, respectively. Manganese doping content could reach up to 65.09±2.55 wt%, providing excellent imaging capability in vivo which the corresponding relaxation efficiency was 14.33 mM −1 s −1 . And outstanding photothermal heating ability and stability highlighted the potential biomedical applicability of MSN(Mn)-ICG/DTIC to kill cancer cells. Experiments by A375 melanoma cells and tumor-bearing mice demonstrated that the compound MSN(Mn)-ICG/DTIC have excellent biocompatibility and our combined therapy platform delivered a superior antitumor effect compared to standalone treatment in vivo and in vitro. Conclusion:Our findings demonstrate that composite MSN(Mn)-ICG/DTIC could serve as a multifunctional platform to achieve a highly effective chemo-photothermal combined therapy for melanoma treatment.

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“…Mirsalari et al . 27 studied the adsorption of the anticancer drug Dacarbazine into the CNT by means of MD simulation. They reported that Decarbazine was inserted spontaneously inside the cavity of the CNT so that the vdW energy decreased and reached the value of − 160 kJ mol −1 at the end of the simulation.…”

Section: Introductionmentioning

confidence: 99%

Encapsulation of an anticancer drug Isatin inside a host nano-vehicle SWCNT: a molecular dynamics simulation

Dehaghani

Yousefi

Seidi

et al. 2021

Sci Rep

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The use of carbon nanotubes as anticancer drug delivery cargo systems is a promising modality as they are able to perforate cellular membranes and transport the carried therapeutic molecules into the cellular components. Our work describes the encapsulation process of a common anticancer drug, Isatin (1H-indole-2,3-dione) as a guest molecule, in a capped single-walled carbon nanotube (SWCNT) host with chirality of (10,10). The encapsulation process was modelled, considering an aqueous solution, by a molecular dynamics (MD) simulation under a canonical NVT ensemble. The interactions between the atoms of Isatin were obtained from the DREIDING force filed. The storage capacity of the capped SWCNT host was evaluated to quantify its capacity to host multiple Isatin molecules. Our results show that the Isatin can be readily trapped inside the volume cavity of the capped SWCNT and it remained stable, as featured by a reduction in the van der Waals forces between Isatin guest and the SWCNT host (at approximately − 30 kcal mol−1) at the end of the MD simulation (15 ns). Moreover, the free energy of encapsulation was found to be − 34 kcal mol−1 suggesting that the Isatin insertion procedure into the SWCNT occurred spontaneously. As calculated, a capped SWCNT (10,10) with a length of 30 Å, was able to host eleven (11) molecules of Isatin, that all remained steadily encapsulated inside the SWCNT volume cavity, showing a potential for the use of carbon nanotubes as drug delivery cargo systems.

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Investigation of the Pristine and Functionalized Carbon Nanotubes as a Delivery System for the Anticancer Drug Dacarbazine: Drug Encapsulation

Cited by 30 publications

References 51 publications

Carbon nanotubes in biomedical applications: current status, promises, and challenges

Carbon nanotubes in biomedical applications: current status, promises, and challenges

Dual Modal Imaging-Guided Drug Delivery System for Combined Chemo-Photothermal Melanoma Therapy

Encapsulation of an anticancer drug Isatin inside a host nano-vehicle SWCNT: a molecular dynamics simulation

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