Investigation of the potential association of vitamin D binding protein with lipoproteins

Speeckaert, Marijn M.; Taes, Youri; Buyzere, Marc L. De; Christophe, Armand; Kaufman, Jean‐Marc; Delanghe, Joris

doi:10.1258/acb.2009.009018

Cited by 45 publications

(18 citation statements)

References 32 publications

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“…Elevated levels of VDP in plasma/serum/CSF have previously been reported in several neuropsychiatric disorders, such as schizophrenia, multiple sclerosis and Guillain-Barre syndrome (d'Aguanno et al 2010 ;Rithidech et al 2009 ;Wan et al 2007). Apart from its role in transporting vitamin D metabolites, VDP also exhibits several other functions including actin scavenging, fatty acid transport and modulation of immune and inflammatory responses (Gomme & Bertolini, 2004 ;Speeckaert et al 2006Speeckaert et al , 2010White & Cooke, 2000). An elevated VDP level may be associated with abnormalities in immunoregulation and the lipid profile found in MDD.…”

Section: Discussionmentioning

confidence: 96%

Comparative proteomic analysis of plasma from major depressive patients: identification of proteins associated with lipid metabolism and immunoregulation

Zhang

Luo

et al. 2012

Int. J. Neuropsychopharm.

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Major depressive disorder is a common neuropsychiatric disorder contributing to several socio-economic burdens including disability and suicide. As the underlying pathophysiology of major depressive disorder remains unclear, no objective test is yet available for aiding diagnosis or monitoring disease progression. To contribute to a better understanding of its pathogenesis, a comparative proteomic study was performed to identify proteins differentially expressed in plasma samples obtained from first-onset, treatment-naive depressed patients as compared to healthy controls. Samples from the two groups were immunodepleted of seven high-abundance proteins, labelled with isobaric tags for relative and absolute quantitation and then analysed by multi-dimensional liquid chromatography-tandem mass spectrometry. The proteomic results were further validated by immunoblotting or enzyme-linked immunoadsorbent assays and analysed with the MetaCore database. The results demonstrate that the functions of the altered proteins are primarily involved in lipid metabolism and immunoregulation. These findings suggest that early perturbation of lipid metabolism and immunoregulation may be involved in the pathophysiology of major depressive disorder.

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Section: Discussionmentioning

confidence: 96%

Comparative proteomic analysis of plasma from major depressive patients: identification of proteins associated with lipid metabolism and immunoregulation

Zhang

Luo

et al. 2012

Int. J. Neuropsychopharm.

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“…On the other hand, with regard to the biochemical components of metabolic syndrome, it is suggested that the protein may be a protective agent against their occurrence. In the analysis of Speeckaert et al ., negative correlations between the VDBP concentration and the fraction of LDL lipoproteins, as well as triglyceridemia, were observed [36]. In addition, it is thought that VDBP, by regulating the amount of active vitamin D in β-cells of the pancreas, may affect insulin secretion, and thus affect the prevalence of insulin resistance and type-2 diabetes mellitus [11].…”

Section: Discussionmentioning

confidence: 99%

Impact of 25-hydroxyvitamin D, free and bioavailable fractions of vitamin D, and vitamin D binding protein levels on metabolic syndrome components

Pelczyńska

Grzelak

Sperling

et al. 2017

aoms

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IntroductionVarious forms of vitamin D and factors involved in their metabolism can play a role in the etiopathogenesis of metabolic disorders. This paper aims to define the relationship between concentration of the hydroxylated form of vitamin D (25(OH)D), the fraction of free and bioavailable vitamin D, and of vitamin D binding protein (VDBP) levels on the one hand and the prevalence of metabolic syndrome components on the other.Material and methodsThe studies were conducted on 79 people, including 52 with metabolic syndrome (MetS+) and 27 without it (MetS–). Biochemical measurements (lipid profile, glycemia, 25(OH)D, VDBP, albumin, calcium, parathyroid hormone) were performed, concentration of free and bioavailable vitamin D was mathematically calculated, and anthropometric and blood pressure measurements were taken.ResultsThe mean ± SD concentration of 25(OH)D among MetS+ individuals (41.90 ±13.12 nmol/l) was lower (p < 0.0001) than among the MetS– group (66.09 ±18.02 nmol/l). Differences between groups were observed in relation to medians/means of concentrations of free and bioavailable vitamin D (p < 0.0001) but not in the case of VDBP. In the entire study population, 25(OH)D correlated with all metabolic syndrome components, whereas its free and bioavailable fraction correlated with particular components of the syndrome. In the MetS+ group, VDBP concentration negatively correlated with body mass index (p = 0.037) and levels of diastolic pressure (p = 0.022). In the case of the MetS– group, the free fraction of vitamin D negatively correlated with triglyceridemia (p = 0.049).ConclusionsThe evaluation of various forms of vitamin D and VDBP in different population groups seems to have significant clinical value in evaluating the prevalence of metabolic disorders.

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“…Vitamin C could also promote LDL receptor activity [39] or modulate cholesterol ester transfer protein activity. The positive association between VLDL concentration and vitamin D intake could be explained by the fact that vitamin D binding protein and 25(OH)-vitamin D(3) are present in VLDL [40]. More VLDL would mean more vitamin D binding protein circulating within these lipoprotein particles and therefore would increase the amount of vitamin D associated.…”

Section: Discussionmentioning

confidence: 99%

Effects of Wheat and Oat-Based Whole Grain Foods on Serum Lipoprotein Size and Distribution in Overweight Middle Aged People: A Randomised Controlled Trial

et al. 2013

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IntroductionEpidemiological studies suggest three daily servings of whole-grain foods (WGF) might lower cardiovascular disease risk, at least partly by lowering serum lipid levels. We have assessed the effects of consuming three daily portions of wholegrain food (provided as wheat or a mixture of wheat and oats) on lipoprotein subclass size and concentration in a dietary randomised controlled trial involving middle aged healthy individuals.MethodsAfter a 4-week run-in period on a refined diet, volunteers were randomly allocated to a control (refined diet), wheat, or wheat + oats group for 12 weeks. Our servings were determined in order to significantly increase the intakes of non starch polysaccharides to the UK Dietary Reference Value of 18 g per day in the whole grain groups (18.5 g and 16.8 g per day in the wheat and wheat + oats groups respectively in comparison with 11.3 g per day in the control group). Outcome measures were serum lipoprotein subclasses' size and concentration. Habitual dietary intake was assessed prior and during the intervention. Of the 233 volunteers recruited, 24 withdrew and 3 were excluded.ResultsAt baseline, significant associations were found between lipoprotein size and subclasses' concentrations and some markers of cardiovascular risk such as insulin resistance, blood pressure and serum Inter cellular adhesion molecule 1 concentration. Furthermore, alcohol and vitamin C intake were positively associated with an anti-atherogenic lipoprotein profile, with regards to lipoprotein size and subclasses' distribution. However, none of the interventions with whole grain affected lipoprotein size and profile.ConclusionOur results indicate that three portions of wholegrain foods, irrelevant of the type (wheat or oat-based) do not reduce cardiovascular risk by beneficially altering the size and distribution of lipoprotein subclasses.Trial Registration www.Controlled-Trials.com ISRCTN 27657880.

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Investigation of the potential association of vitamin D binding protein with lipoproteins

Cited by 45 publications

References 32 publications

Comparative proteomic analysis of plasma from major depressive patients: identification of proteins associated with lipid metabolism and immunoregulation

Comparative proteomic analysis of plasma from major depressive patients: identification of proteins associated with lipid metabolism and immunoregulation

Impact of 25-hydroxyvitamin D, free and bioavailable fractions of vitamin D, and vitamin D binding protein levels on metabolic syndrome components

Effects of Wheat and Oat-Based Whole Grain Foods on Serum Lipoprotein Size and Distribution in Overweight Middle Aged People: A Randomised Controlled Trial

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