Investigation of the potential application of sodium bentonite as an excipient in formulation of sustained release tablets

Alkrad, Jamal Alyoussef; Shmeis, Reham Abu; Alshwabkeh, Iyad; Abazid, Husam; Mohammad, Mohammad Amin

doi:10.1016/j.ajps.2017.01.004

Cited by 12 publications

(8 citation statements)

References 14 publications

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“…Dziadkowiec & coworkers (2017) reported that the prepared ibuprofen-salt loaded nanocomposite from bentonite and neutral guar gum released ibuprofen in a controlled manner (Dziadkowiec et al, 2017). Similarly, Alkrad et al (2017) used a 50% mixture of bentonite with different drugs to study the release behavior from prepared tablets by direct compression (Alkrad et al, 2017). The produced blends had poor flowability, which was considered the main limitation of the direct compression method (Aulton & Taylor, 2013;Franc et al, 2018;Timmins et al, 1991).…”

Section: Discussionmentioning

confidence: 99%

“…Visual observation of the tablets during the dissolution test (Figure 6) showed that bentonite forms a gel structure in dissolution media at pH 7.2, whereas the tablets disintegrated at lower acidic pH, which could be related to the dissolution of montmorillonite at low pH, which was responsible for gel-building in bentonite (Alkrad et al, 2017;Bendou & Amrani, 2014;González-Santamaría et al, 2020;Mouzon et al, 2016). To protect IB-bentonite tablets from harsh acidic media, enteric coating was carried out.…”

Section: Discussionmentioning

confidence: 99%

“…Bentonite as a gel-forming matrix system is considered less expensive than other gelforming polymers, including HPMC. The use of clay minerals such as bentonite and kaolinite in developing sustained release dosage forms has been reported by many studies (Alkrad et al, 2017;Li et al, 2021). The basic pH of bentonite makes it favorable to improve the absorption of class II drugs, such as ibuprofen (IB), by enhancing their solubility (Tantishaiyakul, 2004).…”

Section: Introductionmentioning

confidence: 99%

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Formulation and release kinetics of ibuprofen–bentonite tablets

et al. 2022

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Formulation and release kinetics of ibuprofen–bentonite tablets

et al. 2022

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“…There are some reports that clay improves the stability of drugs, or even prevents or reduces side effects. More recently, the possibility of clay being used as a carrier of drugs or certain significant chemical elements was being investigated due to the high ion exchange capacity, large surface area, chemical inertness and low or zero toxicity [2][3][4][5]. The development of these systems requires a completely solid-state characterization followed by a biopharmaceutical evaluation.…”

Section: Introductionmentioning

confidence: 99%

DEVELOPMENT OF LONG-LASTING ANTIMICROBIAL AND POTENTIAL HEMOSTATIC NANOCOMPOSITES (pyrophyllite based) WITH PVP-coated COLLOIDAL SILVER NANOPARTICLES

Todorović

Saletović

Mihajlović

et al. 2021

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Pyrophyllite clay, modified with PVP coated silver nanoparticles (PYRO-PVP/AgNPs), with recently proved antibacterial activity was prepared. Silver nanoparticles were synthesized by the chemical reduction method of AgNO3 using NaBH4 and poly(vinyl pyrrolidone) (PVP) as a stabilizer and excellent dispersant. This research aimed to elucidate the mechanisms and kinetics of AgNPs, along with the PVP protective mechanism responsible for antibacterial activity towards the microorganisms. Pioneering steps were made toward coagulation studies due to the potential of aluminosilicate layered clays to serve as alternatives to hemostatic agents currently in use. The isoelectric point of pyrophyllite samples with 5, 20, and 45 μm diameter particles and PYRO/PVP/AgNPs sample (Ag25mg/L) was evaluated to understand how the anticoagulant or procoagulant properties of the pyrophyllite varied according to the pH of the isoelectric point. Characterization of the PYRO-PVP/AgNPs samples was performed using FTIR spectroscopy, while the release mechanism and kinetics of silver ions were monitored using atomic absorption spectroscopy (AAS). Additionally, AAS was used for the evaluation of heavy metals content in pyrophyllite clay and a simple, cost-effective procedure was proposed for the extraction of heavy metals.

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“…In fact, the quality of clays for biological applications has been established by several studies. For instance, the pharmaceutical use of clays has been specified in pharmacopoeia standards (European Pharmacopoeia, 2005; Tomasevic-Canovic, 2005; US Pharmacopeia, 2007; Carretero & Pozo, 2009; Alkrad et al ., 2017; Dardir et al ., 2018). It is projected that the utilization of zeolites, specifically Philippine natural zeolites, will be maximized in the future due to their well-defined structures, ability to reversibly bind to small molecules, shape and size selectivity, metallo-enzyme behaviour and immune system regulatory properties (Inoue et al ., 2002; Demirci et al ., 2013; Cerri et al ., 2016).…”

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confidence: 99%

Impregnation of silver in zeolite–chitosan composite: thermal stability and sterility study

2019

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The solvent-casting method was used to synthesize a silver–zeolite–chitosan (AgZ-Ch) composite from Philippine natural zeolites. X-ray diffraction, ultraviolet–visible (UV-Vis) spectroscopy, optical emission spectroscopy (OES), thermogravimetric analysis (TGA) and differential thermogravimetry (DTG) were used to investigate the different properties of the composite before and after plasma treatment. The major phase of the zeolite is Na-clinoptilolite with trace amounts of mordenite, feldspar and quartz. UV-Vis and OES analyses confirmed the presence of Ag and zeolite on the chitosan matrix. The decrease in the transmittance signal at 290 nm and the emission spectra of the discharge showed the presence of Ag I, Al I and Si I signals at 705–852 nm. The TGA and DTG curves revealed the thermal stability of the natural zeolites after ion exchange and after incorporation in the chitosan matrix, where the onset of degradation was observed to occur above ~37°C, the human body temperature. Bacterial count showed minimal growth of colonies on all samples, both pristine and plasma-treated, suggesting that the surface of the composites does not influence bacterial habitation. The fabricated composites meet the minimum requirements for biomedical application such as thermal stability with respect to the average human body temperature and absence of bacteria.

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Investigation of the potential application of sodium bentonite as an excipient in formulation of sustained release tablets

Cited by 12 publications

References 14 publications

Formulation and release kinetics of ibuprofen–bentonite tablets

Formulation and release kinetics of ibuprofen–bentonite tablets

DEVELOPMENT OF LONG-LASTING ANTIMICROBIAL AND POTENTIAL HEMOSTATIC NANOCOMPOSITES (pyrophyllite based) WITH PVP-coated COLLOIDAL SILVER NANOPARTICLES

Impregnation of silver in zeolite–chitosan composite: thermal stability and sterility study

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