Investigation of the pharmacokinetics of sydnocarb by polarography

Al'tshuler, R. A.; Kovalenko, T. A.; Kholodov, L. E.; Polievktov, M. K.

doi:10.1007/bf00758346

Cited by 4 publications

(3 citation statements)

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“…Mesocarb (N-phenylcarbamoyl-3-(␤-phenylisopropyl)sydnoneimine), also known as sydnocarb, was synthesized from amphetamine as a starting material [1][2][3]. It is a central nervous system stimulant (CNS) [4] and is therefore included in the doping list of forbidden substances indicated by the Medical Commission of the International Olympic Committee [5].…”

Section: Introductionmentioning

confidence: 99%

Liquid chromatography—electrospray ionization ion trap mass spectrometry for analysis of mesocarb and its metabolites in human urine

Appolonova¹,

Shpak²,

Semenov³

2004

Journal of Chromatography B

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Section: Introductionmentioning

confidence: 99%

Liquid chromatography—electrospray ionization ion trap mass spectrometry for analysis of mesocarb and its metabolites in human urine

Appolonova¹,

Shpak²,

Semenov³

2004

Journal of Chromatography B

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“…Mesocarb (Sydnocarb) is the central nervous system (CNS) stimulant that was developed in 1970s . As the psychostimulant with antidepressant and anticonvulsant properties, mesocarb was added to the list of banned compounds in sports in 1991 .…”

Section: Introductionmentioning

confidence: 99%

Liquid chromatography electrospray ionization tandem mass spectrometry for the detection of mesocarb abuse in horse doping

Appolonova¹,

Baranov²,

Mesonzhnik³

et al. 2011

Drug Testing and Analysis

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A method is described for the determination of mesocarb abuse in equestrian sport by combining gradient liquid chromatography and electrospray ionization tandem mass spectrometry. Mesocarb was administrated orally to two horses at a dose of 50 µg/kg. Urine samples were collected up to 120 h post administration. Hydrolyzed and conjugated urine fractions were handled using liquid-liquid extraction (LLE). The identity of the parent drug and metabolites was confirmed using liquid chromatography combined with tandem mass spectrometry (MS/MS). Mesocarb and seven metabolites were detected in horse urine. Mono- and two di-hydroxylated metabolites were the main metabolites observed in horse urine samples. Based on the differences in MS/MS spectra it was supposed that these metabolites were been formed by the hydroxylation of the phenylisopropyl moiety of mesocarb whilst the main process of hydroxylation of mesocarb in human occurred in the phenylcarbamoyl moiety. The main metabolites were almost completely glucuroconjugated. Minor metabolites such as p-hydroxymesocarb and three di-hydroxylated metabolites together with parent mesocarb were also presented in the free urine fraction. This study has shown that two mono- and two di-hydroxylated metabolites are useful for controlling the abuse of mesocarb in horses.

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“…This same method has been used to study the pharmacokinetics of an N-phenylcarbonyl derivative of sydnophen, sydnocarb [3].…”

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confidence: 99%

Polarographic study of sydnophen excretion from rat organism

Snyakin

Berlyand

2007

Pharm Chem J

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The urinary excretion of sydnophen from rat organism has been studied using a polarographic technique for the first time. It is shown that approximately one third of the introduced drug dose is excreted unchanged with urine within 24 h. The elimination rate constant (K el = 0.11 h -1 ) and half-elimination time (t 1/2 = 6.3 h) are indicative of a low rate of sydnophen removal from rat organism. The proposed polarographic technique has proven to be reliable and convenient and is recommended for studying the clinical pharmacokinetics of sydnophen. 629 0091-150X/07/4112-0629

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Investigation of the pharmacokinetics of sydnocarb by polarography

Cited by 4 publications

References 0 publications

Liquid chromatography—electrospray ionization ion trap mass spectrometry for analysis of mesocarb and its metabolites in human urine

Liquid chromatography—electrospray ionization ion trap mass spectrometry for analysis of mesocarb and its metabolites in human urine

Liquid chromatography electrospray ionization tandem mass spectrometry for the detection of mesocarb abuse in horse doping

Polarographic study of sydnophen excretion from rat organism

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