Abstract:Transporters belonging in the ATP-binding cassette (ABC) family are crucially involved in the determination of the pharmacokinetic behavior of xenobiotics and in the development of drug resistance. The targeting of these transporters has been accepted as a rational option via which to modify the absorption or distribution of pharmaceutical agents and to combat ABC-related inefficiency. Inhibitors of the breast cancer resistance protein (BCRP/ABCG2) multidrug transporter are of interest as chemosensitizers for … Show more
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