2022
DOI: 10.1002/ange.202202286
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Investigation of the Molecular Landscape of Bacterial Aromatic Polyketides by Global Analysis of Type II Polyketide Synthases

Abstract: Aromatic polyketides biosynthesized by microorganisms are a prominent class of natural products widely used in clinical treatments. Although genome mining approaches have accelerated the discovery of these molecules, the molecular diversity, abundance, and distribution of bacterial aromatic polyketides at a global scale remain elusive. Here, we provide a global atlas of bacterial aromatic polyketides based on large‐scale analysis of type II polyketide synthases. We first established the chain length factor pro… Show more

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Cited by 3 publications
(4 citation statements)
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“…This approach differs from traditional unsupervised learning for clustering (44), as it strives to strike a balance between the sequence embeddings and the compound class labels to improve the model's accuracy. For example, T2PK AQ-256-8 consists of 8 building blocks, but its KSβ is confirmed as ancestral nonoxidative, which differs from other KSβs that involve the biosynthesis of T2PKs with 8 building blocks (6). Clearly, the state-of-the-art performance of the model trained with 9 refined class labels suggests that the classification effect is unsatisfactory when simply using five biosynthetic building blocks as labels.…”
Section: Discussionmentioning
confidence: 99%
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“…This approach differs from traditional unsupervised learning for clustering (44), as it strives to strike a balance between the sequence embeddings and the compound class labels to improve the model's accuracy. For example, T2PK AQ-256-8 consists of 8 building blocks, but its KSβ is confirmed as ancestral nonoxidative, which differs from other KSβs that involve the biosynthesis of T2PKs with 8 building blocks (6). Clearly, the state-of-the-art performance of the model trained with 9 refined class labels suggests that the classification effect is unsatisfactory when simply using five biosynthetic building blocks as labels.…”
Section: Discussionmentioning
confidence: 99%
“…T2 polyketide synthase is a family of single heterodimeric ketosynthases that iteratively catalyzes the elongation of the polyketide chain structure, leading to our inability to precisely predict T2PK structures. As introduced previously, despite the multiple sequence alignment approaches based on KSβ (5,6), incorporation of new sequences into the evolutionary model may alter the structure of the original phylogenetic tree and therefore compromise the accuracy of the predictions. To address Fig.…”
Section: Discussionmentioning
confidence: 99%
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