Investigation of the miRNA146a and miRNA155 gene expression levels in patients with multiple sclerosis

Shademan, Behrouz; Nourazarian, Alireza; Nikanfar, Masoud; Avcı, Çığır Biray; Hasanpour, Mehdi; Isazadeh, Alireza

doi:10.1016/j.jocn.2020.04.071

Cited by 23 publications

(17 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Multiple sclerosis (MS) is a neurodegenerative disorder that causes in ammation in the central nerve system (CNS), which leads to neuropathy [19,20]. According to epidemiological studies, its prevalence is closely associated with nutrition, and it commonly occurs in people with high levels of fatty acid and Vitamin D de ciency [21].…”

Section: Discussionmentioning

confidence: 99%

The Relationship Between Serum Orexin A, TGF-β, and Leptin Levels with Body Mass Index in Multiple Sclerosis Patients

Moharami

Nourazarian

Nikanfar

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

Backgrounds: Multiple Sclerosis (MS) is a chronic inflammatory and autoimmune disease linked to several inflammatory and dietary parameters. This study was carried out to determine the relationship between serum leptin, orexin-A, and TGF-β levels with BMI in MS patients.Methods and results: In this cross-sectional study, 25 relapsing-remitting multiple sclerosis (RRMS) patients and 40 healthy controls were enrolled. The serum level of Leptin, Orexin-A, and TGF- were measured by the Enzyme-linked immunosorbent assay (ELISA). The data was analyzed using descriptive statistics, t-test, Chi-square test, and Linear regression test. A total of 65 volunteers, including 25 MS patients and 40 healthy, were enrolled in the study. The mean age of individuals in the case and control groups was 38.04 ± 7.53 and 40.23 ± 5.88. There were no statistically significant differences between the case and control groups regarding gender, age, alcohol, and cigarette use (P>0.05). The mean serum levels of Orexin-A and TGF-ß were lower among multiple sclerosis patients than in healthy controls, but leptin was higher (42.8 vs. 18.9 ng/ml, P<0.001). The relationship between BMI and serum levels of Orexin-A, TGF-ß, and Leptin among Multiple Sclerosis patients was not statistically significant (P > 0.05).Conclusion: Our results showed that the serum levels of Orexin-A and TGF-β were significantly lower. The serum level of leptin was higher among multiple sclerosis patients than among healthy controls. Also, there was no statistically significant relationship between BMI and serum levels of Orexin-A, TGF-ß, and Leptin among multiple sclerosis patients.

show abstract

Section: Discussionmentioning

confidence: 99%

The Relationship Between Serum Orexin A, TGF-β, and Leptin Levels with Body Mass Index in Multiple Sclerosis Patients

Moharami

Nourazarian

Nikanfar

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…The pro-inflammatory effect of miR-155 affects microglia activation, phagocytosis of myelin by macrophages [ 63 ], differentiation of T-cells towards Th1 or Th2 [ 71 ], contribution to increased permeability of the BBB, and infiltration of peripheral immune cells [ 72 ]. In recent studies, attempts have been made to check potential links between the miR-155 expression level and depression, cognitive functions, and neuropathic pain [ 55 , 73 , 74 , 75 , 76 ]. As miR-155 is generally associated with inflammation, it is likely to be involved in various pathophysiological processes and symptoms of MS.…”

Section: Mir-155 and Immune Responsementioning

confidence: 99%

miR-155 as an Important Regulator of Multiple Sclerosis Pathogenesis. A Review

Maciak

Dziedzic

Miller

et al. 2021

IJMS

View full text Add to dashboard Cite

Multiple sclerosis (MS) is a chronic, immune-mediated disease and the leading cause of disability among young adults. MicroRNAs (miRNAs) are involved in the post-transcriptional regulation of gene expression. Of them, miR-155 is a crucial regulator of inflammation and plays a role in modulating the autoimmune response in MS. miR-155 is involved in blood–brain barrier (BBB) disruption via down-regulation of key junctional proteins under inflammatory conditions. It drives demyelination processes by contributing to, e.g., microglial activation, polarization of astrocytes, and down-regulation of CD47 protein and affecting crucial transcription factors. miR-155 has a huge impact on the development of neuropathic pain and indirectly influences a regulatory T (Treg) cell differentiation involved in the alleviation of pain hypersensitivity. This review also focused on neuropsychiatric symptoms appearing as a result of disease-associated stressors, brain atrophy, and pro-inflammatory factors. Recent studies revealed the role of miR-155 in regulating anxiety, stress, inflammation in the hippocampus, and treatment-resistant depression. Inhibition of miR-155 expression was demonstrated to be effective in preventing processes involved in the pathophysiology of MS. This review aimed to support the better understanding the great role of miR-155 dysregulation in various aspects of MS pathophysiology and highlight future perspectives for this molecule.

show abstract

“…Their expression may be a marker of tissue health or disease. These miRNAs can be used as potential biomarkers for diagnosis, prognosis, and treatment [13].…”

Section: Introductionmentioning

confidence: 99%

Type 2 Diabetes and its Effects on MicroRNA-155 and MicroRNA-133a Expression in Lung Tissue of Male Rats

Khezri

Rahbarghazi‬

Ahmadi

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

Background: The presence of an extensive vascular extent and large amounts of collagen and elastin in lung tissue make the lung parenchyma vulnerable to damage in diabetes. However, there are few studies on the pathophysiological effects of diabetes on lung tissue. In this study, we investigated the effects of type 2 diabetes on lung tissue pathology and the expression of miRNA-155 and miRNA-133a in lung tissue of male rats.Methods: In this study, 14 male rats were divided into a control group and a group with diabetes. The group with diabetes received a high-fat diet and a single dose of streptozotocin for one month. After induction of T2D, the rats received a normal diet for the next four weeks. At week 8, the rats were euthanized, and lung tissue was collected to measure microRNAs and examine tissue changes.Results: When lung tissue sections from diabetic rats were examined, the normal structure of the alveoli and alveolar sacs and bronchioles was disturbed. The thickness of interalveolar septa was increased due to the infiltration of inflammatory cells. The extensive alveolar collapse was the main cause of lung tissue structure disruption, and the accumulation of inflammatory cells and exudate secretions resulted in an interstitial pneumonia-like appearance. The expression of miRNA-155 was increased, and the expression of miRNA-133a was decreased in the lungs of diabetic rats compared with control rats.Conclusion: We found significant changes in the lung tissue of diabetic rats. By studying changes in the expression of microRNAs in diabetes, they can be a diagnostic and therapeutic biomarker in the lungs of patients with diabetes.

show abstract

Investigation of the miRNA146a and miRNA155 gene expression levels in patients with multiple sclerosis

Cited by 23 publications

References 21 publications

The Relationship Between Serum Orexin A, TGF-β, and Leptin Levels with Body Mass Index in Multiple Sclerosis Patients

The Relationship Between Serum Orexin A, TGF-β, and Leptin Levels with Body Mass Index in Multiple Sclerosis Patients

miR-155 as an Important Regulator of Multiple Sclerosis Pathogenesis. A Review

Type 2 Diabetes and its Effects on MicroRNA-155 and MicroRNA-133a Expression in Lung Tissue of Male Rats

Contact Info

Product

Resources

About