Investigation of the microstructure and mineralogical composition of urinary calculi fragments by synchrotron radiation X-ray microtomography: a feasibility study

Kaiser, Jozef; Holá, Markéta; Galiová, Michaela Vašinová; Novotný, Karel; Kanický, Viktor; Martinec, Petr; Ščučka, Jiří; Brun, Francesco; Sodini, Nikola; Tromba, Giuliana; Mancini, Lucia; Kořistková, Tamara

doi:10.1007/s00240-010-0343-9

Cited by 26 publications

(21 citation statements)

References 28 publications

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“…Finally, intense SHG signal was generated by struvite because of its noncentrosymmetric orthorhombic crystal structure. These five chemical components constitute the majority (93.5%) of human urinary stones . The results presented in this work show that four of them can be clearly discriminated in the multimodal images.…”

Section: Resultsmentioning

confidence: 59%

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Microstructure of urinary stones as studied by means of multimodal nonlinear optical imaging

Pučetaitė

Tamošaitytė

Galli

et al. 2016

J Raman Spectroscopy

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Tracing aetiology and pathogenesis of urinary stone disease is of great importance in order to prescribe appropriate treatment and prevent recurrences. For this purpose, morphological examination combined with determination of chemical composition of urinary stones is fundamental. In this work, we have evaluated the potential of multimodal nonlinear optical imaging for investigation of (micro)structure and chemical composition of human urinary stones. The method provides high‐resolution multimodal images of the cross‐sectioned stones without any labelling or some other pretreatment of the samples. We have shown that various constituents of urinary stones can be well discriminated in the multimodal images according to their optical signals. In addition, small structures (1–5 µm in size) were observed in the cross‐sections of urinary stones of various types. These structures were identified as crystallites of uric acid. They could either act as an active element during formation of urinary stones or, more probably, be accidentally incorporated into their structure, as it is suggested by random distribution of the crystallites. The results of this work show that multimodal nonlinear optical imaging can provide relevant information about growth processes of urinary stones and deliver useful insights in aetiology and pathogenesis of urolithiasis. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Resultsmentioning

confidence: 59%

“…Methods such as X‐ray diffraction and Fourier transform infrared (FT‐IR) (micro)spectroscopy are widely used nowadays and are able to determine chemical composition of single‐component urinary stones . Major chemical constituents in multicomponent stones can be identified and quantified as well.…”

Section: Introductionmentioning

confidence: 99%

Microstructure of urinary stones as studied by means of multimodal nonlinear optical imaging

Pučetaitė

Tamošaitytė

Galli

et al. 2016

J Raman Spectroscopy

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“…Such structural characterization on pathological calcifications can be performed either through various classical physical techniques (Evan et al, 2007;Rao et al, 2011;Bazin et al, 2006), such as scanning electron microscopy (SEM) (Grà cia-Garcia et al, 2011;Dessombz, Mé ria et al, 2011, micro-computerized tomography (Williams et al, 2012;Kaiser et al, 2011), Fourier transform infrared (FTIR) and Raman spectroscopy (Quy Dao & Daudon, 1997;Estepa & Daudon, 1998;Guerra-Lopez et al, 2008;Wilson et al, 2010), proton induced X-ray emission (Pineda-Vargas et al, 2009), and laser ablation methods (Stepankova et al, 2013), or through techniques specific to large instruments, such as micro X-ray fluorescence (Bazin et al, 2007), micro X-ray absorption spectroscopy Carpentier et al, 2010;Nguyen et al, 2011), micro FTIR spectroscopy or neutron scattering (Bazin, André et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Therapy modifies cystine kidney stones at the macroscopic scale. Do such alterations exist at the mesoscopic and nanometre scale?

et al. 2014

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International audienceWith an incidence of 1:7000 births, cystinuria, the most frequent cause of stone formation among genetic diseases, represents a major medical problem. Twentyfive cystine stones randomly selected from cystinuric patients were investigated. From a crystallographic point of view, cystine stones are composed of micrometre size crystallites, which are made up of an aggregation of nanocrystals. Through scanning electron microscopy, the morphology and size of the crystallites have been described, while the size of the nanocrystals was investigated by means of powder neutron diffraction. Powder neutron diffraction analysis and/or scanning electron microscopy examination of cystine stones provide evidence that usual alkalinization by sodium bicarbonate associated with high diuresis significantly reduces the size of both nanocrystals and crystallites, while for other treatments, including alkalinizing drugs and thiol derivatives, the data suggest mainly changes in the topology of crystallites. Alkalinization with sodium bicarbonate affects cystine kidney stones at the mesoscopic and nanoscopic scales, while other medical treatments only alter their surface. Such an approach may help to assess the interaction between drugs and cystine stones in cystinuric patients

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“…A 3D visualisation of a specimen can be constructed through the processing of several consecutive slices. 10 Using special SW, the following characteristics can be determined on a 3D image of a specimen:…”

Section: Computed Tomographymentioning

confidence: 99%

Possibilities of determining the air-pore content in cement composites using computed tomography and other methods

Moravcová¹,

Pőssl²,

Misák³

et al. 2016

Mater. Tehnol.

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The aim of the paper is to outline the possibilities and predictive values of the selected methods for determining air-pore characteristics in concrete and cement composites in general. Four samples (mixtures) of cement concrete without additives or admixtures were chosen for the measurement, differing in cement content while maintaining the consistency of fresh concrete S3 according to EN 206. Both standardized and non-standardized methods are used in Europe, therefore providing a possibility of comparing their outcomes. Keywords: concrete, durability, porosity, surface, covering layer, X-ray computed micro-tomography Namen~lanka je prikazati mo`nosti za splo{no napovedovanje izbranih metod za dolo~anje zna~ilnosti zra~nih por v betonu in v kompozitih iz cementa. Za meritve so bili izbrani {tirje vzorci (me{anice) betona brez dodatkov in primesi z razli~no vsebnostjo cementa ob zadr`anju konsistence sve`ega betona S3, skladno z EN 206. Standardizirane in nestandardizirane metode se uporabljajo v Evropi in zato omogo~ajo primerjavo rezultatov.

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Investigation of the microstructure and mineralogical composition of urinary calculi fragments by synchrotron radiation X-ray microtomography: a feasibility study

Cited by 26 publications

References 28 publications

Microstructure of urinary stones as studied by means of multimodal nonlinear optical imaging

Microstructure of urinary stones as studied by means of multimodal nonlinear optical imaging

Therapy modifies cystine kidney stones at the macroscopic scale. Do such alterations exist at the mesoscopic and nanometre scale?

Possibilities of determining the air-pore content in cement composites using computed tomography and other methods

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