Investigation of the micellar properties of the tocopheryl polyethylene glycol succinate surfactants TPGS 400 and TPGS 1000 by steady state fluorometry

Sadoqi, Mostafa; Lau‐Cam, Cesar A.; Wu, Stephen H.

doi:10.1016/j.jcis.2009.01.048

Cited by 68 publications

(35 citation statements)

References 28 publications

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“…TPGS surfactants are amphiphilic macromolecules consisting of a hydrophilic polar polyethylene glycol (PEG) segment and a hydrophobic tocopheryl (vitamin E) segment 19. The TPGS that has been used for NPs formulation for drug delivery is TPGS 1000 (TPGS1k), which has been proved to be an effective surfactant for NP formation for drug delivery, for example, the quantity of TPGS needed to make the same amount of NPs is only 1/67 of poly(vinyl alcohol) (PVA) by weight 20.…”

Section: Introductionmentioning

confidence: 99%

Surfactant chain length effects on nanoparticles of biodegradable polymers for targeted drug delivery

Liu

Feng

2012

AIChE Journal

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Folic acid‐conjugated nanoparticles (NPs) of biodegradable polymer poly(lactic‐co‐glycolic acid) (PLGA), which were emulsified by long‐chain D‐α‐tocopheryl polyethylene glycol succinate (vitamin E TPGS or simply TPGS) for targeted delivery of anticancer drugs, are prepared. The NPs were characterized for their size and size distribution, surface morphology, surface charge, drug encapsulation efficiency, and surface chemistry. The cellular uptake and the cytotoxicity of the drug‐loaded PLGA NPs were assessed in vitro with MCF7 breast cancer cells in close comparison with the corresponding Short‐chain TPGS (TPGS2k)‐coated PLGA NPs and the original drug. The long‐chain TPGS 2000 (TPGS2k)‐emulsified PLGA NPs showed great advantages over the short‐chain TPGS 1000 (TPGS1k)‐emulsified and the nude PLGA NPs. The folic acid‐conjugated TPGS2k‐emulsified PLGA NPs showed significant advantages in cellular uptake and therapeutic effects in vitro. The IC50 value showed 90.4% less than that of the original drug. © 2012 American Institute of Chemical Engineers AIChE J, 2012

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Section: Introductionmentioning

confidence: 99%

Surfactant chain length effects on nanoparticles of biodegradable polymers for targeted drug delivery

Liu

Feng

2012

AIChE Journal

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“…The nonionic surfactant series, ie, Tween ® 80, Tween ® 60, Tween ® 20, and Tween ® 85, and the Span ® series, ie, Span ® 80, Span ® 60, Span ® 20, and Span ® 85, were chosen for screening. Generally, polyoxyethylene sorbitan mono-oleate, such as Tween ® 80 with a hydrophilic-lipophilic balance (HLB) value of 15.0 and sorbitan oleate or Span ® 80 with an HLB value of 4.3, were chosen for screening because they have a high degree of compatibility with other ingredients, good chemical stability, and low toxicity 13. Span ® 80 is a viscous, lipophilic, emulsifying liquid agent which tends to form water-in-oil emulsions 14.…”

Section: Introductionmentioning

confidence: 99%

Effect of surfactant and surfactant blends on pseudoternary phase diagram behavior of newly synthesized palm kernel oil esters

Mahdi¹,

Sakeena²,

Abdulkarim³

et al. 2011

DDDT

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Background:The purpose of this study was to select appropriate surfactants or blends of surfactants to study the ternary phase diagram behavior of newly introduced palm kernel oil esters.Methods:Nonionic surfactant blends of Tween® and Tween®/Span® series were screened based on their solubilization capacity with water for palm kernel oil esters. Tween® 80 and five blends of Tween® 80/Span® 80 and Tween® 80/Span® 85 in the hydrophilic-lipophilic balance (HLB) value range of 10.7–14.0 were selected to study the phase diagram behavior of palm kernel oil esters using the water titration method at room temperature.Results:High solubilization capacity was obtained by Tween® 80 compared with other surfactants of Tween® series. High HLB blends of Tween® 80/Span® 85 and Tween® 80/Span® 80 at HLB 13.7 and 13.9, respectively, have better solubilization capacity compared with the lower HLB values of Tween® 80/Span® 80. All the selected blends of surfactants were formed as water-in-oil microemulsions, and other dispersion systems varied in size and geometrical layout in the triangles. The high solubilization capacity and larger areas of the water-in-oil microemulsion systems were due to the structural similarity between the lipophilic tail of Tween® 80 and the oleyl group of the palm kernel oil esters.Conclusion:This study suggests that the phase diagram behavior of palm kernel oil esters, water, and nonionic surfactants is not only affected by the HLB value, but also by the structural similarity between palm kernel oil esters and the surfactant used. The information gathered in this study is useful for researchers and manufacturers interested in using palm kernel oil esters in pharmaceutical and cosmetic preparation. The use of palm kernel oil esters can improve drug delivery and reduce the cost of cosmetics.

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“…Pegylation of vitamin E forming derivatives such as tocopherol polyethylene glycol succinate (TPGS) provides water-solubility and surfactant properties to the vitamin E and allows the formation of micelles [42].…”

Section: Polymeric Micellesmentioning

confidence: 99%

Fate of polymeric nanocarriers for oral drug delivery

Plapied

Duhem

Rieux

et al. 2011

Current Opinion in Colloid & Interface Science

291

173

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Investigation of the micellar properties of the tocopheryl polyethylene glycol succinate surfactants TPGS 400 and TPGS 1000 by steady state fluorometry

Cited by 68 publications

References 28 publications

Surfactant chain length effects on nanoparticles of biodegradable polymers for targeted drug delivery

Surfactant chain length effects on nanoparticles of biodegradable polymers for targeted drug delivery

Effect of surfactant and surfactant blends on pseudoternary phase diagram behavior of newly synthesized palm kernel oil esters

Fate of polymeric nanocarriers for oral drug delivery

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