Investigation of the methanol root extract ofCochlospermum planchoniifor pharmacological activitiesin vitroandin vivo

Anaga, Aruh O.; Oparah, NnekaQ.

doi:10.3109/13880200902973795

Cited by 12 publications

(14 citation statements)

References 19 publications

(24 reference statements)

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“…An acute toxicity test of an extract from maceration in methanol, administered orally to 30 mice, showed no mortality at doses up to 1000 mg/kg. 18 In subacute toxicity tests, the water extract of the rhizome was administered orally to 30 albino rats at a dose of 50 mg/kg per day for 1, 3, 5, 10, and 15 days. 19 This was associated with a reduced activity of liver alkaline phosphatase and slightly reduced creatinine, albumin, and bilirubin levels.…”

Section: Cochlospermum Planchoniimentioning

confidence: 99%

SAYE: The Story of an Antimalarial Phytomedicine from Burkina Faso

Dakuyo¹,

Meda

et al. 2015

The Journal of Alternative and Complementary Medicine

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Section: Cochlospermum Planchoniimentioning

confidence: 99%

SAYE: The Story of an Antimalarial Phytomedicine from Burkina Faso

Dakuyo¹,

Meda

et al. 2015

The Journal of Alternative and Complementary Medicine

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“…Cochlospermum planchonii is a medicinal plant used in West Africa to treat a number of diseases. It has been described as anti-plasmodial (Benoit-Vical et al, 2001), anti-inflammatory (Benoit-Vical et al, 2003;Anaga and Oparah, 2009), anti-bacterial (Isah et al, 2013), hepatoprotective (Aliyu et al, 1995), and anti-diabetic (Nafiu et al, 2011) agent. A previous work in our laboratory has shown that C. planchonii hydroethanolic root extract (2.5 and 5% in gel) administered topically has significant in vivo burn wound healing activity in mice (Nakpane et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Phytochemical screening and antimicrobial activities of hydroethanolic extracts from leaves and roots of Cochlospermum planchonii (Bixaceae)

Fankibe¹,

Metowogo²,

Kantati³

et al. 2020

J. Pharmacognosy Phytother.

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Cochlospermum planchonii is traditionally used in Togo in treating several diseases, including burn wounds which achievement requires anti-infective and good cicatrisation processes. This study aims to evaluate the antimicrobial properties of hydroethanolic extracts from leaves and roots of C. planchonii and its phytochemical composition. Five (05) bacterial strains were suspended in liquid media with plant extracts at various concentrations and then spread, after 24 h incubation, on solid media. The minimum inhibitory (MIC) and minimal microbicidal (MMC) concentrations were assessed. Phytochemical characterization tests were performed and flavonoids, tannins and total phenol contents were also determined. Hydroethanolic extracts from the leaves and roots of C. planchonii were active on all the germs tested, with MICs ranging from 0.782 to 50 mg/mL and MMCs ranging from 1.563 to 100 mg/mL. The bests activities were recorded with root extract against Staphylococcus aureus: MIC=0.782 mg/mL and MMC =1.563 mg/mL. The MMC/MIC ratios are all equal to 2, indicating that both roots and leaves have bactericidal activities rather than inhibitory activities. Phytochemical tests have demonstrated the presence of metabolites such as flavonoids, tannins, carbohydrates, sterols, triterpenes, saponosides, and an absence of alkaloids. Total phenols, tannins and total flavonoids amounts found were respectively 85.466 ± 0.289; 33.566 ± 0.503; 218.333 ± 0.577 µgRE/mg in root extracts, and 75.833 ± 0.289; 26.533 ± 0,053; 183.666 ± 0.577 µgRE/mg in leaf extracts. Both root and leaf hydroethanolic extracts of C. planchonii could be potential natural antimicrobial remedies.

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“…The root extracts of the plant are the most frequently used part employed in folk medicine in Nigeria and other West Africa countries for the treatment of various kinds of diseases such as malaria and fever, infertility, premenstrual pain, gonorrhea, diabetes, hyperlipidemia (Benoit-Vical et al, 2001), stomach disorder, typhoid fever and urinary tract infection (Togola et al, 2008). Some studies have also documented the anti-diabetic (Anaga & Oparah, 2009;Yakubu et al, 2010), antimalarial (Benoit-Vical et al, 2001Vonthron-Sénécheau et al, 2003), anti-diarrheal (Ezeja & Anaga, 2010, antibacterial (Isah et al, 2013), antiinflammatory and analgesic (Anaga & Oparah, 2009) activities of the roots extract of this plant. Nafiu et al (2011) earlier reported the phytochemical constituents of C. planchonii root extract, however information on the antihyperlipdemic activity of the plant is lacking.…”

Section: Introductionmentioning

confidence: 99%

Anti-Hyperlipidemic Activity of Polyphenol-Rich Extract of Cochlospermum Planchonii Roots in Triton x-100 Induced Rats

Nafiu

Salawu

Idowu

et al. 2020

Fountain Journal of Natural and Applied Sciences

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Cochlospermum planchonii is used for treatment of cardiovascular diseases in Nigeria and in some other African countries. This study investigated the anti-hyperlipidemic activity of polyphenol-rich extract of C. planchonii root in triton X-induced hyperlipidemic rats. Polyphenols were extracted from roots of C. planchonii with 80% aqueous methanol and acetone. Thirty female albino rats were randomized into six groups of five (5) rats each, Group I the non-hyperlipidemic control received saline only, group II the hyperlipidemic group received only saline, group III served as hyperlipidemic rats treated with 10 mg/kg b.w.Â atorvastatin while group(s) V-VII were hyperlipidemic rats treated with 25, 50 and 100 mg/kg b.w polyphenol-rich extract of C. Planchonii respectively. The effect of the administration of the extract on the serum lipid profile and hematological parameters was investigated. C. planchonii roots contained 47.7 Â± 0.23 mg gallic acid equivalent / g dry extract and 49.14 Â± 0.23 mg quercetin acid equivalent / g dry extract. Significant (p < 0.05) increase observed in serum total cholesterol, triacylglycerol and low-density lipoprotein with concomitant reduction in high-density lipoprotein concentration were mitigated by the polyphenol-rich extract. No significant changes were observed in the hematological indices of the hyperlipidemic rats at the doses investigated when compared to the control. The results indicated that polyphenol-rich extract of C. planchonii root exhibited anti-hyperlipidemic activity. Thus, it could be promoted as a recipe for protection against hyperlipidemia.

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Investigation of the methanol root extract ofCochlospermum planchoniifor pharmacological activitiesin vitroandin vivo

Cited by 12 publications

References 19 publications

SAYE: The Story of an Antimalarial Phytomedicine from Burkina Faso

SAYE: The Story of an Antimalarial Phytomedicine from Burkina Faso

Phytochemical screening and antimicrobial activities of hydroethanolic extracts from leaves and roots of Cochlospermum planchonii (Bixaceae)

Anti-Hyperlipidemic Activity of Polyphenol-Rich Extract of Cochlospermum Planchonii Roots in Triton x-100 Induced Rats

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