Investigation of the metabolic oxidation of acenaphthen-1-ol

Abstract

value as authentic 2 -deoxy -2 -sulphoamino -Dglucose. The electrophoretic mobility of this 35S-labelled product also coincided with that of 2-deoxy-2-sulphoamino-D-glucose.The enzymically prepared heparan [35S]sulphate was degraded with nitrous acid (Lagunoff & Warren, 1962) and the products were fractionated on a Sephadex G-15 column. Approx. 75% of the radioactivity was eluted with inorganic sulphate. These results suggest that predominantly N-sulphate groups are synthesized in the presence of the ox lung enzyme.

Species variations in the metabolism of phenol

“…These experiments showed that both the microsomal system and the cytosol are active with NADI and NADP+, and that NADI is the preferred cofactor for both systems. These cofactor requirements for the microsomal oxidation of methylphenylcarbinol are similar to those for the oxidation of acenaphthen-l-ol and cis-and trans-acenaphthene-1,2-diol (Simmons et al, 1971;Drummond, 1971). The oxidation of these latter compounds by the cytosol, however, has a specific requirement for NADP+.…”

“…Reduction of acetophenone, however, does occur in the rabbit and the dog (Smith et al, 1954b;Leibman, 1971;Sundvik, 1886). The present investigation was undertaken to determine whether methylphenylcarbinol is oxidized in a manner similar to other carbinols such as indan-1-ol (Billings et al, 1971) and acenaphthen-l-ol (Simmons et al, 1971), which gave rise to the corresponding ketones.…”