Investigation of the membrane-active properties of acyl derivatives of 2,3-benzo-18-crown-6

Shkinëv, A. V.; Gagel’gans, A. I.; Ташмухамедова, А. К.

doi:10.1007/bf00570819

Chem Nat Compd

1979

DOI: 10.1007/bf00570819

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Investigation of the membrane-active properties of acyl derivatives of 2,3-benzo-18-crown-6

A. V. Shkinëv¹,

A. I. Gagel’gans²,

А. К. Ташмухамедова³

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1986

1991

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Transport of alkali cations through thin lipid membranes by (222)C10-Cryptand, an ionizable mobile carrier

Castaing¹,

Morel²,

Lehn

1986

J. Membrain Biol.

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The kinetics of K+ and Na+ transport across the membrane of large unilamellar vesicles (L.U.V.) were compared at two pH's, with two carriers: (222)C10-cryptand (diaza-1,10-decyl-5-hexaoxa-4,7,13,16,21,24-bicyclo[8.8.8.]+ ++hexacosane) and valinomcyin, i.e. an ionizable macrobicyclic amino polyether and a neutral macrocyclic antibiotic. The rate of cation transport by (222)C10 saturated as cation and carrier concentrations rose. The apparent affinity of (222)C10 for K+ was higher and less pH dependent than that for Na+ but resembled the affinity of valinomycin for K+. The efficiency of (222)C10 transport of K+ decreased as the pH fell and the carrier concentration rose, and was about ten times lower than that of valinomycin. Noncompetitive K+/Na+ transport selectivity of (222)C10 decreased as pH, and cation and carrier concentrations rose, and was lower than that of valinomycin. Transport of alkali cations by (222)C10 and valinomycin was noncooperative. Reaction orders in cation n(S) and carrier m(M) varied with the type of cation and carrier and were almost independent of pH; n(S) and m(M) were not respectively dependent on carrier or cation concentrations. The apparent estimated constants for cation translocation by (222)C10 were higher in the presence of Na+ than of K+ due to higher carrier saturation by K+, and decreased as pH and carrier concentration increased. Equilibrium potential was independent of the nature of carrier and transported cation. Results are discussed in terms of the structural, physiocochemical and electrical characteristics of carriers and complexes.

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Transport of alkali cations through thin lipid membranes by (222)C10-Cryptand, an ionizable mobile carrier

Castaing¹,

Morel²,

Lehn

1986

J. Membrain Biol.

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Permeability of cryptands through dihexadecyl phosphate bilayer membranes

Castaing

Kraus

Ponge

1991

Biophysical Chemistry

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Investigation of the membrane-active properties of acyl derivatives of 2,3-benzo-18-crown-6

Cited by 2 publications

References 2 publications

Transport of alkali cations through thin lipid membranes by (222)C10-Cryptand, an ionizable mobile carrier

Transport of alkali cations through thin lipid membranes by (222)C10-Cryptand, an ionizable mobile carrier

Permeability of cryptands through dihexadecyl phosphate bilayer membranes

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