Investigation of the mechanism of action of nonablative pulsed-dye laser therapy in photorejuvenation and inflammatory acne vulgaris

Abstract

TGF-beta is known to be a potent stimulus for neocollagenesis and a pivotal immunosuppressive cytokine which promotes inflammation resolution. Its upregulation by NA-PDL provides a possible unifying molecular mechanism linking stimulation of dermal remodelling in photorejuvenation with inhibition of inflammation in acne. Damage to P. acnes or sebaceous glands cannot explain the effect of this device in acne.

Comparison of a 585-nm pulsed dye laser and a 1064-nm Nd:YAG laser for the treatment of acne scars: A randomized split-face clinical study

“…On the other hand, although TGF-b expression was increased in a few specimens at 8 weeks, no overall significant increase was observed, which contrasts with a previous observation that TGF-b mRNA expression was significantly up-regulated at 24 hours after PDL. 36 This difference may be attributed to the temporal variability of TGFb, which mainly participates during early wound healing and neocollagenesis. 38 Thereby, TGF-b expression following initial tissue derangement from laser therapy decreases with time.…”

New insights into the management of acne: An update from the Global Alliance to Improve Outcomes in Acne Group

“…148,149 Because there has been no in vivo demonstration of an antimicrobial effect, more research is needed to elucidate the mechanism of action in acne. Treatments that affect P acnes, including antibacterial agents and light sources, generally are effective only when used CONSENSUS: More Data Are Needed to Define the Role of Laser and Light Therapy in Acne Level of Evidence: V d Available optical devices target P acnes or the sebaceous gland o In vivo effects on P acnes have not been shown; are there other unknown mechanisms of action?…”

Treatment of Acne Vulgaris With Salicylic Acid Chemical Peel and Pulsed Dye Laser: A Split Face, Rater-Blinded, Randomized Controlled Trial

“…Low fluences have been shown to stimulate collagen production which can help with acne scarring. [11][12][13] The use of various superficial chemical peels, particularly the agent salicylic acid (SA), have been found to be efficacious in the treatment of acne with superficial peels. [14][15][16][17] SA peels soften the stratum corneum and cause skin shedding by loosening the intracellular matrix and corneocyte connections which can lead to an improvement in non-inflammatory comedones.…”