Investigation of the laxative, spasmolytic and prokinetic properties of aqueous methanol extract of &lt;i&gt;Buxus sempervirens&lt;/i&gt; Linn (Buxaceae)

Hamid, Irfan; Janbaz, Khalid Hussain

doi:10.4314/tjpr.v16i8.16

Cited by 2 publications

(4 citation statements)

References 12 publications

(14 reference statements)

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“…[ 25 ] The increase in small intestine contractility might be due to the stimulatory influence of some phytochemical components of GK on intestinal muscarinic receptor. [ 17 ] The quantitative phytochemical screening of GK seeds (g/100 g) was reported and revealed phenols 0.147 ± 0.00, saponins 2.471 ± 0.00, alkaloids 0.647 ± 0.20, flavonoids 2.041 ± 0.30, and glycosides 3.421 ± 0.00. [ 26 ]…”

Section: Discussionmentioning

confidence: 99%

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Antidiabetic and antiradical effects of Garcinia kola seeds in dexamethasone-induced hyperglycemic rats

Nkono¹,

Rouamba²,

Kinyok³

et al. 2022

Int J App Basic Med Res

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Background In traditional medicine, the maceration of seeds of Garcinia kola (GK) is used to treat various diseases including diabetes. In traditional pharmacopoeia, GK seeds are used to strengthen the immune system and as a stimulant and aphrodisiac. Aims This study aimed to evaluate the antidiabetic free radical scavenging effects of the hydroalcoholic extract of GK seeds (HAEGS) in a dexamethasone-induced hyperglycemic (DexIH) rat model. Settings and Design This study was an interventional study. Subjects and Methods Here using in vivo model, we assessed some pharmacological properties of HAEGS in DexIH rat. Hypoglycemia, antihyperglycemia, spasmolytic and laxative activities were also evaluated in DexIH. In vitro study assessed antiradical activity. The HAEGS was obtained by decoction introducing 250 g with water–ethanol mixture (30:70). The plant extract was administered to the animals at doses of 50 (GK50) and 100 (GK100) mg/kg body weight. All animal experiments were in accordance with ARRIVE guidelines and were performed in accordance with the scientific procedures of UK Animals. Antiradical activity of GK was assessed in vitro by inhibition of the activity of 2,2-diphenyl-1-picrylhydrazyl. Statistical Analysis Used Statistical analysis was performed using GraphPad Prism 5.03 software, and P values less than 0.05 were considered statistically significant. Results At doses 50 and 100 mg/kg, GK significantly ( P < 0.001) regulated DexIH after two weeks of treatment compared to the normoglycemic control and hyperglycemic rats. The extract at both doses significantly ( P < 0.001) inhibited the spasmolytic activity in both normoglycemic and hyperglycemic rats compared to Imodium ® . In rats DexIH rats, only dose 100 mg/kg significantly ( P < 0.05) increased laxative effects when compared to the negative control. In vitro antiradical activity of GK revealed vitamin C-like antiradical activity. Conclusions This study justifies the traditional use of GK seeds as an antidiabetic.

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Section: Discussionmentioning

confidence: 99%

“…The determination of the spasmolytic and laxative effects (%) was made by calculation as previously described[ 17 ] using equations (1) and (2) as follows:…”

Section: Methodsmentioning

confidence: 99%

Antidiabetic and antiradical effects of Garcinia kola seeds in dexamethasone-induced hyperglycemic rats

Nkono¹,

Rouamba²,

Kinyok³

et al. 2022

Int J App Basic Med Res

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“…Secondary metabolites of diverse chemical nature including alkaloids, flavonoids, phenols, saponins, and tannins were detected from the extract by reported procedures as described by Hamid et al (12). The phytochemical screening of the dichloromethane fraction of extract indicated the presence of alkaloids, resins, fats, and waxes (14).…”

Section: Phytochemical Analysismentioning

confidence: 99%

“…Several pharmacological studies showed its antibacterial, anti-diabetic, anti-oxidant, anti-proliferative, antifungal, anti-atherosclerotic, cytotoxic, neuro-protective, gastro-protective and hepato-protective potential. C. siliqua pods are traditionally used in the treatment of diarrhea, vomiting, asthma, cough, hyper-peristalsis, cardiovascular diseases, high cholesterol, diabetes, obesity, pain, and inflammation (12).…”

Section: Introductionmentioning

confidence: 99%

Therapeutic potential of Ceratonia siliqua extract for the management of asthma and hypertension

Hamid

Janbaz

Iqbal

et al. 2022

Cell Mol Biol (Noisy-le-grand)

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The current work was performed to explore the pharmacological mechanisms involved in the management of asthma and hypertension along with the safety profile of the Ceratonia siliqua (C. siliqua/Carob) pods. The bronchorelaxant, vasorelaxant, and cardioselective activities of C. siliqua pods were investigated using isolated rabbit tracheal, aortic, and paired atrial fragments on the Power lab data acquisition system. Normotensive rats were used to study antihypertensive activity. The plant extract and its fractions relaxed the carbachol-induced contraction in the tracheal fragments and shifted the concentration-response curve of carbachol towards the right confirming the muscarinic receptor antagonist activity. The relaxation of phenylephrine-induced contraction in an aortic fragment by the extract showed α- adrenergic blocking activity. Furthermore, the extract produced a cardio-selective response in the paired atria and decreased the blood pressure in anesthetized normotensive rats. The plant extract proved to be non-toxic in oral acute and chronic toxicity studies and did not demonstrate any sign of histopathological lesions. These results suggested that the plant extract was non-toxic and could be used in the management of lifetime therapies of respiratory and cardiovascular disorders without any unwanted effects.

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Investigation of the laxative, spasmolytic and prokinetic properties of aqueous methanol extract of <i>Buxus sempervirens</i> Linn (Buxaceae)

Cited by 2 publications

References 12 publications

Antidiabetic and antiradical effects of Garcinia kola seeds in dexamethasone-induced hyperglycemic rats

Antidiabetic and antiradical effects of Garcinia kola seeds in dexamethasone-induced hyperglycemic rats

Therapeutic potential of Ceratonia siliqua extract for the management of asthma and hypertension

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